First tidal volume greater than 8 mL/kg is associated with increased mortality in complicated influenza infection with acute respiratory distress syndrome

for Taiwan Severe Influenza Research Consortium (TSIRC) Investigators, Ming Cheng Chan, Wen Cheng Chao, Shinn Jye Liang, Chien Hua Tseng, Hao Chien Wang, Ying Chun Chien, Kuang Yao Yang, Wei Chih Chen, Wann Cherng Perng, Kuo Chin Kao, Han Chung Hu, Chau Chyun Sheu, Wei An Chang, Wen Feng Fang, Yu Mu Chen, Arthur S. Slutsky, Chieh Liang Wu

Research output: Contribution to journalArticle

Abstract

Backgrounds: Severe influenza infection causes substantial morbidity and mortality worldwide and remains an important threat to global health. This study addressed factors related to treatment outcomes in subjects of complicated influenza infection with acute respiratory distress syndrome (ARDS) during the Taiwan epidemic in the Spring of 2016. Methods: This is a retrospective study conducted by Taiwan Severe Influenza Research Consortium (TSIRC), including eight tertiary referral medical centers. Patients with virology-proven influenza infection admitted to intensive care unit (ICU) between January and March 2016 were included for analysis. Results: We identified 263 patients with complicated influenza infection who fulfilled ARDS criteria; the mean age was 59.8 ± 14.6 (years), and 66.1% (166/263) were male. Type A influenza (77.9%, 205/263) virus was the main pathogen during this epidemic. The 30-day mortality rate was 23.2% (61/263). The mean tidal volume (VT) in the first three days after intubation was greater than 8 mL/kg of predicted body weight (PBW). Patients whose first measured VT was >8 mL/kg PBW had an increased 30-day mortality (p = 0.04, log-rank test). In a multivariate Cox proportional hazard regression model, an increase of 1 mL/kg PBW of first VT was associated with 26.1% increase in 30-day mortality (adjusted hazard ratio 1.261, 95% confidence interval [CI] 1.072–1.484, p < 0.01). Conclusions: First tidal volume, shortly after intubation, greater than 8 mL/kg PBW is an independent risk factor for mortality in complicated influenza infection with ARDS. Timely recognition of ARDS with strict adherence to protective ventilation strategy of lowering VT may be important in reducing mortality.

Original languageEnglish
JournalJournal of the Formosan Medical Association
DOIs
Publication statusAccepted/In press - Jan 1 2018
Externally publishedYes

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Tidal Volume
Adult Respiratory Distress Syndrome
Human Influenza
Mortality
Infection
Body Weight
Taiwan
Intubation
Virology
Proportional Hazards Models
Tertiary Care Centers
Intensive Care Units
Ventilation
Retrospective Studies
Confidence Intervals
Viruses
Morbidity
Research

Keywords

  • Acute respiratory distress syndrome
  • Influenza
  • Tidal volume

ASJC Scopus subject areas

  • Medicine(all)

Cite this

First tidal volume greater than 8 mL/kg is associated with increased mortality in complicated influenza infection with acute respiratory distress syndrome. / for Taiwan Severe Influenza Research Consortium (TSIRC) Investigators; Chan, Ming Cheng; Chao, Wen Cheng; Liang, Shinn Jye; Tseng, Chien Hua; Wang, Hao Chien; Chien, Ying Chun; Yang, Kuang Yao; Chen, Wei Chih; Perng, Wann Cherng; Kao, Kuo Chin; Hu, Han Chung; Sheu, Chau Chyun; Chang, Wei An; Fang, Wen Feng; Chen, Yu Mu; Slutsky, Arthur S.; Wu, Chieh Liang.

In: Journal of the Formosan Medical Association, 01.01.2018.

Research output: Contribution to journalArticle

for Taiwan Severe Influenza Research Consortium (TSIRC) Investigators, Chan, MC, Chao, WC, Liang, SJ, Tseng, CH, Wang, HC, Chien, YC, Yang, KY, Chen, WC, Perng, WC, Kao, KC, Hu, HC, Sheu, CC, Chang, WA, Fang, WF, Chen, YM, Slutsky, AS & Wu, CL 2018, 'First tidal volume greater than 8 mL/kg is associated with increased mortality in complicated influenza infection with acute respiratory distress syndrome', Journal of the Formosan Medical Association. https://doi.org/10.1016/j.jfma.2018.06.010
for Taiwan Severe Influenza Research Consortium (TSIRC) Investigators ; Chan, Ming Cheng ; Chao, Wen Cheng ; Liang, Shinn Jye ; Tseng, Chien Hua ; Wang, Hao Chien ; Chien, Ying Chun ; Yang, Kuang Yao ; Chen, Wei Chih ; Perng, Wann Cherng ; Kao, Kuo Chin ; Hu, Han Chung ; Sheu, Chau Chyun ; Chang, Wei An ; Fang, Wen Feng ; Chen, Yu Mu ; Slutsky, Arthur S. ; Wu, Chieh Liang. / First tidal volume greater than 8 mL/kg is associated with increased mortality in complicated influenza infection with acute respiratory distress syndrome. In: Journal of the Formosan Medical Association. 2018.
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abstract = "Backgrounds: Severe influenza infection causes substantial morbidity and mortality worldwide and remains an important threat to global health. This study addressed factors related to treatment outcomes in subjects of complicated influenza infection with acute respiratory distress syndrome (ARDS) during the Taiwan epidemic in the Spring of 2016. Methods: This is a retrospective study conducted by Taiwan Severe Influenza Research Consortium (TSIRC), including eight tertiary referral medical centers. Patients with virology-proven influenza infection admitted to intensive care unit (ICU) between January and March 2016 were included for analysis. Results: We identified 263 patients with complicated influenza infection who fulfilled ARDS criteria; the mean age was 59.8 ± 14.6 (years), and 66.1{\%} (166/263) were male. Type A influenza (77.9{\%}, 205/263) virus was the main pathogen during this epidemic. The 30-day mortality rate was 23.2{\%} (61/263). The mean tidal volume (VT) in the first three days after intubation was greater than 8 mL/kg of predicted body weight (PBW). Patients whose first measured VT was >8 mL/kg PBW had an increased 30-day mortality (p = 0.04, log-rank test). In a multivariate Cox proportional hazard regression model, an increase of 1 mL/kg PBW of first VT was associated with 26.1{\%} increase in 30-day mortality (adjusted hazard ratio 1.261, 95{\%} confidence interval [CI] 1.072–1.484, p < 0.01). Conclusions: First tidal volume, shortly after intubation, greater than 8 mL/kg PBW is an independent risk factor for mortality in complicated influenza infection with ARDS. Timely recognition of ARDS with strict adherence to protective ventilation strategy of lowering VT may be important in reducing mortality.",
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T1 - First tidal volume greater than 8 mL/kg is associated with increased mortality in complicated influenza infection with acute respiratory distress syndrome

AU - for Taiwan Severe Influenza Research Consortium (TSIRC) Investigators

AU - Chan, Ming Cheng

AU - Chao, Wen Cheng

AU - Liang, Shinn Jye

AU - Tseng, Chien Hua

AU - Wang, Hao Chien

AU - Chien, Ying Chun

AU - Yang, Kuang Yao

AU - Chen, Wei Chih

AU - Perng, Wann Cherng

AU - Kao, Kuo Chin

AU - Hu, Han Chung

AU - Sheu, Chau Chyun

AU - Chang, Wei An

AU - Fang, Wen Feng

AU - Chen, Yu Mu

AU - Slutsky, Arthur S.

AU - Wu, Chieh Liang

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Backgrounds: Severe influenza infection causes substantial morbidity and mortality worldwide and remains an important threat to global health. This study addressed factors related to treatment outcomes in subjects of complicated influenza infection with acute respiratory distress syndrome (ARDS) during the Taiwan epidemic in the Spring of 2016. Methods: This is a retrospective study conducted by Taiwan Severe Influenza Research Consortium (TSIRC), including eight tertiary referral medical centers. Patients with virology-proven influenza infection admitted to intensive care unit (ICU) between January and March 2016 were included for analysis. Results: We identified 263 patients with complicated influenza infection who fulfilled ARDS criteria; the mean age was 59.8 ± 14.6 (years), and 66.1% (166/263) were male. Type A influenza (77.9%, 205/263) virus was the main pathogen during this epidemic. The 30-day mortality rate was 23.2% (61/263). The mean tidal volume (VT) in the first three days after intubation was greater than 8 mL/kg of predicted body weight (PBW). Patients whose first measured VT was >8 mL/kg PBW had an increased 30-day mortality (p = 0.04, log-rank test). In a multivariate Cox proportional hazard regression model, an increase of 1 mL/kg PBW of first VT was associated with 26.1% increase in 30-day mortality (adjusted hazard ratio 1.261, 95% confidence interval [CI] 1.072–1.484, p < 0.01). Conclusions: First tidal volume, shortly after intubation, greater than 8 mL/kg PBW is an independent risk factor for mortality in complicated influenza infection with ARDS. Timely recognition of ARDS with strict adherence to protective ventilation strategy of lowering VT may be important in reducing mortality.

AB - Backgrounds: Severe influenza infection causes substantial morbidity and mortality worldwide and remains an important threat to global health. This study addressed factors related to treatment outcomes in subjects of complicated influenza infection with acute respiratory distress syndrome (ARDS) during the Taiwan epidemic in the Spring of 2016. Methods: This is a retrospective study conducted by Taiwan Severe Influenza Research Consortium (TSIRC), including eight tertiary referral medical centers. Patients with virology-proven influenza infection admitted to intensive care unit (ICU) between January and March 2016 were included for analysis. Results: We identified 263 patients with complicated influenza infection who fulfilled ARDS criteria; the mean age was 59.8 ± 14.6 (years), and 66.1% (166/263) were male. Type A influenza (77.9%, 205/263) virus was the main pathogen during this epidemic. The 30-day mortality rate was 23.2% (61/263). The mean tidal volume (VT) in the first three days after intubation was greater than 8 mL/kg of predicted body weight (PBW). Patients whose first measured VT was >8 mL/kg PBW had an increased 30-day mortality (p = 0.04, log-rank test). In a multivariate Cox proportional hazard regression model, an increase of 1 mL/kg PBW of first VT was associated with 26.1% increase in 30-day mortality (adjusted hazard ratio 1.261, 95% confidence interval [CI] 1.072–1.484, p < 0.01). Conclusions: First tidal volume, shortly after intubation, greater than 8 mL/kg PBW is an independent risk factor for mortality in complicated influenza infection with ARDS. Timely recognition of ARDS with strict adherence to protective ventilation strategy of lowering VT may be important in reducing mortality.

KW - Acute respiratory distress syndrome

KW - Influenza

KW - Tidal volume

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