First phase release coefficient of insulin in subjects with normal glucose tolerance on glucose infusion analyzed by computer simulation

Chien Ning Huang, Wen Chih Chou, Li Yun Lin, Chiung Chi Peng, Charng Cherng Chyau, Kuan Chou Chen, Robert Y. Peng

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report here a mathematical model using computer simulation to solve the phase fractionation coefficient (f) of instantaneous insulin release on glucose infusion. By extensive model testing with the cited parameters obtained from the literature, the values of the factor f were shown to lie in range of 0.93 ± 0.02 (mean ± 2S.D., n = 15), indicating that the high pulsatile bolus of glucose by i.v. infusion may trigger acute insulin release (AIR) corresponding to a fraction of more than 90% of the stored insulin release in the first phase from the secretory granules of pancreatic β cells. In addition, the value of the factor f was shown to be independent of both the glucose infusion method and the non-insulin-dependent uptake of glucose.

Original languageEnglish
Pages (from-to)146-157
Number of pages12
JournalBioSystems
Volume91
Issue number1
DOIs
Publication statusPublished - Jan 2008
Externally publishedYes

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Keywords

  • Glucose infusion
  • Insulin release
  • Phase fractionation coefficient

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biotechnology
  • Drug Discovery

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