First description of Klebsiella pneumoniae harboring CTX-M β-lactamases (CTX-M-14 and CTX-M-3) in Taiwan

Liang Yu Wen, Patricia L. Winokur, Diana L. Von Stein, Michael A. Pfaller, Hsien Wang Jen, Ronald N. Jones

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Klebsiella pneumoniae isolates from Taiwan medical centers (50 strains; 1998 to 2000) with a CTX-M resistance phenotype (ceftazidime susceptible and ceftriaxone or cefotaxime nonsusceptible) were selected for initial isoelectric focusing analysis. β-Lactamases with pIs of 7.9 (n = 22) and 8.4 (n = 28) in addition to 5.4 and/or 7.6 were detected. DNA gene sequencing identified the β-lactamases with pIs of 7.9 and 8.4 as CTX-M-14 and CTX-M-3, respectively. Molecular typing suggested inter- and intrahospital clonal dissemination of these Taiwanese CTX-M-producing Klebsiella strains.

Original languageEnglish
Pages (from-to)1098-1100
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume46
Issue number4
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Molecular Typing
Ceftazidime
Klebsiella
Cefotaxime
Ceftriaxone
Klebsiella pneumoniae
Isoelectric Focusing
Taiwan
DNA Sequence Analysis
Phenotype
Genes

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

First description of Klebsiella pneumoniae harboring CTX-M β-lactamases (CTX-M-14 and CTX-M-3) in Taiwan. / Wen, Liang Yu; Winokur, Patricia L.; Von Stein, Diana L.; Pfaller, Michael A.; Jen, Hsien Wang; Jones, Ronald N.

In: Antimicrobial Agents and Chemotherapy, Vol. 46, No. 4, 2002, p. 1098-1100.

Research output: Contribution to journalArticle

Wen, Liang Yu ; Winokur, Patricia L. ; Von Stein, Diana L. ; Pfaller, Michael A. ; Jen, Hsien Wang ; Jones, Ronald N. / First description of Klebsiella pneumoniae harboring CTX-M β-lactamases (CTX-M-14 and CTX-M-3) in Taiwan. In: Antimicrobial Agents and Chemotherapy. 2002 ; Vol. 46, No. 4. pp. 1098-1100.
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