Fibulin-5/DANCE is essential for elastogenesis in vivo

Tomoyuki Nakamura, Pilar Ruiz Lozano, Yasuhiro Ikeda, Yoshitaka Iwanaga, Aleksander Hinek, Susumu Minamisawa, Ching Feng Cheng, Kazuhiro Kobuke, Nancy Dalton, Yoshikazu Takada, Kei Tashiro, John Ross, Tasuku Honjo, Kenneth R. Chien

Research output: Contribution to journalArticle

459 Citations (Scopus)

Abstract

The elastic fibre system has a principal role in the structure and function of various types of organs that require elasticity, such as large arteries, lung and skin1,2. Although elastic fibres are known to be composed of microfibril proteins (for example, fibrillins and latent transforming growth factor (0TGF)-β-binding proteins) and polymerized elastin, the mechanism of their assembly and development is not well understood. Here we report that fibulin-5 (also known as DANCE), a recently discovered integrin ligand3, is an essential determinant of elastic fibre organization. fibulin-5-/- mice generated by gene targeting exhibit a severely disorganized elastic fibre system throughout the body. fibulin-5-/- mice survive to adulthood, but have a tortuous aorta with loss of compliance, severe emphysema, and loose skin (cutis laxa). These tissues contain fragmented elastin without an increase of elastase activity, indicating defective development of elastic fibres. Fibulin-5 interacts directly with elastic fibres in vitro, and serves as a ligand for cell surface integrins αvβ3, αvβ5 and α9β1 through its amino-terminal domain. Thus, fibulin-5 may provide anchorage of elastic fibres to cells, thereby acting to stabilize and organize elastic fibres in the skin, lung and vasculature.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalNature
Volume415
Issue number6868
DOIs
Publication statusPublished - Jan 10 2002
Externally publishedYes

Fingerprint

Elastic Tissue
Integrins
Cutis Laxa
Microfibrils
Lung
Skin
Gene Targeting
fibulin
Elastin
Pancreatic Elastase
Emphysema
Elasticity
Transforming Growth Factors
Compliance
Aorta
Arteries
Ligands

ASJC Scopus subject areas

  • General

Cite this

Nakamura, T., Lozano, P. R., Ikeda, Y., Iwanaga, Y., Hinek, A., Minamisawa, S., ... Chien, K. R. (2002). Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature, 415(6868), 171-175. https://doi.org/10.1038/415171a

Fibulin-5/DANCE is essential for elastogenesis in vivo. / Nakamura, Tomoyuki; Lozano, Pilar Ruiz; Ikeda, Yasuhiro; Iwanaga, Yoshitaka; Hinek, Aleksander; Minamisawa, Susumu; Cheng, Ching Feng; Kobuke, Kazuhiro; Dalton, Nancy; Takada, Yoshikazu; Tashiro, Kei; Ross, John; Honjo, Tasuku; Chien, Kenneth R.

In: Nature, Vol. 415, No. 6868, 10.01.2002, p. 171-175.

Research output: Contribution to journalArticle

Nakamura, T, Lozano, PR, Ikeda, Y, Iwanaga, Y, Hinek, A, Minamisawa, S, Cheng, CF, Kobuke, K, Dalton, N, Takada, Y, Tashiro, K, Ross, J, Honjo, T & Chien, KR 2002, 'Fibulin-5/DANCE is essential for elastogenesis in vivo', Nature, vol. 415, no. 6868, pp. 171-175. https://doi.org/10.1038/415171a
Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S et al. Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature. 2002 Jan 10;415(6868):171-175. https://doi.org/10.1038/415171a
Nakamura, Tomoyuki ; Lozano, Pilar Ruiz ; Ikeda, Yasuhiro ; Iwanaga, Yoshitaka ; Hinek, Aleksander ; Minamisawa, Susumu ; Cheng, Ching Feng ; Kobuke, Kazuhiro ; Dalton, Nancy ; Takada, Yoshikazu ; Tashiro, Kei ; Ross, John ; Honjo, Tasuku ; Chien, Kenneth R. / Fibulin-5/DANCE is essential for elastogenesis in vivo. In: Nature. 2002 ; Vol. 415, No. 6868. pp. 171-175.
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