Fibronectin receptor structures in the VLA family of heterodimers

Yoshikazu Takada, Christina Huang, Martin E. Hemler

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

Multiple cell surface proteins of relative molecular mass 115,000-155,000 (Mr 115K-155K) have been implicated as receptors mediating adhesion to extracellular matrix proteins1-16. But the organization and relatedness of these peptides has remained unclear. In separate studies, the 'very late antigens' VLA-1 (Mr 210K/130K) and VLA-2 (Mr 160K/130K) were initially characterized as surface heterodimers appearing 2-4 weeks after in vitro stimulation of human T cells17-19. Three more VLA heterodimers have since been discovered, which, like VLA-1 and VLA-2 (refs 18,20,21), are each composed of unique α-subunits in association with a common 130K β subunit22. This paper shows that the common VLA β-subunit is equivalent to subunits found in structures with known fibronectin and laminin receptor activity9-12, and that VLA-3 and VLA-522 are similar or identical to these previously defined receptors for adhesion molecules. Antibody blocking studies confirmed that at least some of the widely distributed VLA proteins of previously unknown function are involved in cell adhesion to fibronectin and laminin. We suggest that the VLA family of receptors may provide cells with multiple independent substrate adhesion capabilities.

Original languageEnglish
Pages (from-to)607-609
Number of pages3
JournalNature
Volume326
Issue number6113
Publication statusPublished - 1987
Externally publishedYes

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Integrin alpha1beta1
Integrin alpha2beta1
Integrin alpha5beta1
Laminin
Very Late Antigen Receptors
Integrin alpha3beta1
Blocking Antibodies
Fibronectins
Cell Adhesion
Extracellular Matrix
Membrane Proteins
Antigens
Peptides
Proteins
adhesion receptor

ASJC Scopus subject areas

  • General

Cite this

Takada, Y., Huang, C., & Hemler, M. E. (1987). Fibronectin receptor structures in the VLA family of heterodimers. Nature, 326(6113), 607-609.

Fibronectin receptor structures in the VLA family of heterodimers. / Takada, Yoshikazu; Huang, Christina; Hemler, Martin E.

In: Nature, Vol. 326, No. 6113, 1987, p. 607-609.

Research output: Contribution to journalArticle

Takada, Y, Huang, C & Hemler, ME 1987, 'Fibronectin receptor structures in the VLA family of heterodimers', Nature, vol. 326, no. 6113, pp. 607-609.
Takada Y, Huang C, Hemler ME. Fibronectin receptor structures in the VLA family of heterodimers. Nature. 1987;326(6113):607-609.
Takada, Yoshikazu ; Huang, Christina ; Hemler, Martin E. / Fibronectin receptor structures in the VLA family of heterodimers. In: Nature. 1987 ; Vol. 326, No. 6113. pp. 607-609.
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