Fibronectin in blood invokes the development of focal segmental glomerulosclerosis in mouse model

Hao Ai Shui; Shuk Man Ka; Jung Chen Lin; Jien Huei Lee; Jong Shiaw Jin; Yuh Feng Lin; Lai Fa Sheu; Ann Chen

doi:10.1093/ndt/gfl113

Fibronectin in blood invokes the development of focal segmental glomerulosclerosis in mouse model

Hao Ai Shui, Shuk Man Ka, Jung Chen Lin, Jien Huei Lee, Jong Shiaw Jin, Yuh Feng Lin, Lai Fa Sheu, Ann Chen

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Background. Focal segmental glomerulosclerosis (FSGS) is caused by gradual deposition of extracellular matrix proteins, one of which, fibronectin (FN) is critical for sclerosis development. The origin of the FN deposited at an early stage of FSGS is still unclear. Methods. For investigating the origin of FN, the onset of increases in FN levels in the serum, glomeruli and urine were studied in a mouse model induced by adriamycin and compared with the time-course of development of glomerulosclerosis and expression of FN mRNA. Results. In the FSGS mice, serum FN levels were significantly increased as early as the onset of proteinuria on day 4 (7.26±0.37 mg/ml compared with 5.58±0.76 mg/ml in normal controls, P

Original language	English
Pages (from-to)	1794-1802
Number of pages	9
Journal	Nephrology Dialysis Transplantation
Volume	21
Issue number	7
DOIs	https://doi.org/10.1093/ndt/gfl113
Publication status	Published - Jul 2006
Externally published	Yes

Keywords

Adriamycin
Biomarker
Fibronectin
Focal segmental glomerulosclerosis
Laser microdissection

ASJC Scopus subject areas

Nephrology
Transplantation

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10.1093/ndt/gfl113

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title = "Fibronectin in blood invokes the development of focal segmental glomerulosclerosis in mouse model",

abstract = "Background. Focal segmental glomerulosclerosis (FSGS) is caused by gradual deposition of extracellular matrix proteins, one of which, fibronectin (FN) is critical for sclerosis development. The origin of the FN deposited at an early stage of FSGS is still unclear. Methods. For investigating the origin of FN, the onset of increases in FN levels in the serum, glomeruli and urine were studied in a mouse model induced by adriamycin and compared with the time-course of development of glomerulosclerosis and expression of FN mRNA. Results. In the FSGS mice, serum FN levels were significantly increased as early as the onset of proteinuria on day 4 (7.26±0.37 mg/ml compared with 5.58±0.76 mg/ml in normal controls, P",

keywords = "Adriamycin, Biomarker, Fibronectin, Focal segmental glomerulosclerosis, Laser microdissection",

author = "Shui, {Hao Ai} and Ka, {Shuk Man} and Lin, {Jung Chen} and Lee, {Jien Huei} and Jin, {Jong Shiaw} and Lin, {Yuh Feng} and Sheu, {Lai Fa} and Ann Chen",

year = "2006",

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doi = "10.1093/ndt/gfl113",

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publisher = "Oxford University Press",

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AU - Shui, Hao Ai

AU - Ka, Shuk Man

AU - Lin, Jung Chen

AU - Lee, Jien Huei

AU - Jin, Jong Shiaw

AU - Lin, Yuh Feng

AU - Sheu, Lai Fa

AU - Chen, Ann

PY - 2006/7

Y1 - 2006/7

N2 - Background. Focal segmental glomerulosclerosis (FSGS) is caused by gradual deposition of extracellular matrix proteins, one of which, fibronectin (FN) is critical for sclerosis development. The origin of the FN deposited at an early stage of FSGS is still unclear. Methods. For investigating the origin of FN, the onset of increases in FN levels in the serum, glomeruli and urine were studied in a mouse model induced by adriamycin and compared with the time-course of development of glomerulosclerosis and expression of FN mRNA. Results. In the FSGS mice, serum FN levels were significantly increased as early as the onset of proteinuria on day 4 (7.26±0.37 mg/ml compared with 5.58±0.76 mg/ml in normal controls, P

AB - Background. Focal segmental glomerulosclerosis (FSGS) is caused by gradual deposition of extracellular matrix proteins, one of which, fibronectin (FN) is critical for sclerosis development. The origin of the FN deposited at an early stage of FSGS is still unclear. Methods. For investigating the origin of FN, the onset of increases in FN levels in the serum, glomeruli and urine were studied in a mouse model induced by adriamycin and compared with the time-course of development of glomerulosclerosis and expression of FN mRNA. Results. In the FSGS mice, serum FN levels were significantly increased as early as the onset of proteinuria on day 4 (7.26±0.37 mg/ml compared with 5.58±0.76 mg/ml in normal controls, P

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KW - Biomarker

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KW - Focal segmental glomerulosclerosis

KW - Laser microdissection

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JO - Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress

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IS - 7

ER -

Fibronectin in blood invokes the development of focal segmental glomerulosclerosis in mouse model

Abstract

Keywords

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