Fibroblast growth factor receptor 2 overexpression is predictive of poor prognosis in rectal cancer patients receiving neoadjuvant chemoradiotherapy

Chien Feng Li, Hong Lin He, Jaw Yuan Wang, Hsuan Ying Huang, Ting Fe Wu, Chung-Hsi Hsing, Sung Wei Lee, Hao Hsien Lee, Jui Lung Fang, Wen Tsung Huang, Shang Hung Chen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aims Neoadjuvant concurrent chemoradiotherapy (CCRT) followed by surgery is an increasingly used therapeutic strategy for advanced rectal cancer, but risk stratification and final outcomes remain suboptimal. Recently, the oncogenic role of the fibroblast growth factor/fibroblast growth factor receptor (FGFR) signalling pathway has been recognised; however, its clinical significance in rectal cancer has not been elucidated. In this study, we identify and validate targetable drivers associated with the FGFR signalling pathway in rectal cancer patients treated with CCRT.

Methods Using a published transcriptome of rectal cancers, we found FGFR2 gene significantly predicted response to CCRT. The expression levels of FGFR2, using immunohistochemistry assays, were further evaluated in 172 rectal cancer specimens that had not received any treatment. Expression levels of FGFR2 were statistically correlated with major clinicopathological features and clinical survival in this valid cohort.

Results High expression of FGFR2 was significantly related to advanced pretreatment tumour (p=0.022) and nodal status (p=0.026), post-treatment tumour (p

Conclusions High expression of FGFR2 is correlated with advanced tumour stage, poor therapeutic response and worse survival in rectal cancer patients receiving neoadjuvant CCRT. These findings indicate that FGFR2 is a prognostic factor for treating rectal cancer.

Original languageEnglish
Pages (from-to)1056-1061
Number of pages6
JournalJournal of Clinical Pathology
Volume67
Issue number12
DOIs
Publication statusPublished - Dec 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

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    Li, C. F., He, H. L., Wang, J. Y., Huang, H. Y., Wu, T. F., Hsing, C-H., Lee, S. W., Lee, H. H., Fang, J. L., Huang, W. T., & Chen, S. H. (2014). Fibroblast growth factor receptor 2 overexpression is predictive of poor prognosis in rectal cancer patients receiving neoadjuvant chemoradiotherapy. Journal of Clinical Pathology, 67(12), 1056-1061. https://doi.org/10.1136/jclinpath-2014-202551