Fibroblast growth factor 23: A possible cause of left ventricular hypertrophy in hemodialysis patients

Heng Jung Hsu, Mai Szu Wu

Research output: Contribution to journalArticlepeer-review

135 Citations (Scopus)

Abstract

BACKGROUND: Left ventricular hypertrophy (LVH) is a common cardiovascular disorder and an independent risk factor for cardiovascular death in dialysis patients. Hyperphosphatemia is associated with LVH. Previous studies have shown that fibroblast growth factor 23 (FGF23), which has an important role in phosphate metabolism, is elevated in chronic hemodialysis patients. OBJECTIVES: The aim of this study is to determine the association of FGF23 and LVH and the prognostic value of FGF23 in chronic hemodialysis patients. MATERIALS AND METHODS: One hundred twenty-four end-stage renal disease patients were evaluated for LVH by echocardiography. Serum FGF23 levels were measured using a commercial enzyme-linked immunosorbent assay kit. RESULTS: Patients with LVH were more likely to have poor urea clearance (Kt/V), higher systolic blood pressure, and comorbidity of diabetes mellitus and coronary artery disease. LVH was also associated with higher levels of FGF23. Multivariate analysis indicated that FGF23 level, systolic blood pressure, and comorbidity of diabetes mellitus and coronary artery disease remained correlated with LVH. This suggested that serum FGF23 level is independently associated with LVH in our hemodialysis patients. Cox analysis indicated no significant difference in risk of death for patients with elevated levels of FGF23. CONCLUSION: LVH has a high prevalence in hemodialysis patients, and FGF23 is independently associated with LVH but is not a predictor for short-term prognosis (2-year follow-up).

Original languageEnglish
Pages (from-to)116-122
Number of pages7
JournalAmerican Journal of the Medical Sciences
Volume337
Issue number2
DOIs
Publication statusPublished - Feb 2009
Externally publishedYes

Keywords

  • End-stage renal disease
  • ESRD
  • FGF23
  • Fibroblast growth factor 23
  • Hemodialysis
  • Left ventricular hypertrophy

ASJC Scopus subject areas

  • Medicine(all)

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