Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis

S. U. Chen; H. N. Ho; H. F. Chen; T. C. Tsai; T. Y. Lee; Y. S. Yang

doi:10.1016/s0015-0282(16)58406-4

Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis

S. U. Chen, H. N. Ho, H. F. Chen, T. C. Tsai, T. Y. Lee, Y. S. Yang

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Objective: To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. Design: Clinical trial. Setting: Reproductive unit of a university teaching hospital. Patient: A patient of obstructive azoospermia with defective spermiogenesis. Intervention: Testicular biopsy after scrotal exploration and spermatid injection into the cytoplasm of oocyte. Main Outcome Measures: Fertilization and cleavage. Results: Four of 13 spermatid injections achieved normal fertilization and 2 of them cleaved. Conclusion: Intracytoplasmic spermatid injection may be a possible treatment for patients of defective spermiogenesis who have no viable spermatozoa available.

Original language	English
Pages (from-to)	157-160
Number of pages	4
Journal	Fertility and Sterility
Volume	66
Issue number	1
DOIs	https://doi.org/10.1016/s0015-0282(16)58406-4
Publication status	Published - Jan 1 1996
Externally published	Yes

Keywords

defective spermiogenesis
Intracytoplasmic spermatid injection
obstructive azoospermia

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynaecology

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title = "Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis",

abstract = "Objective: To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. Design: Clinical trial. Setting: Reproductive unit of a university teaching hospital. Patient: A patient of obstructive azoospermia with defective spermiogenesis. Intervention: Testicular biopsy after scrotal exploration and spermatid injection into the cytoplasm of oocyte. Main Outcome Measures: Fertilization and cleavage. Results: Four of 13 spermatid injections achieved normal fertilization and 2 of them cleaved. Conclusion: Intracytoplasmic spermatid injection may be a possible treatment for patients of defective spermiogenesis who have no viable spermatozoa available.",

keywords = "defective spermiogenesis, Intracytoplasmic spermatid injection, obstructive azoospermia",

author = "Chen, {S. U.} and Ho, {H. N.} and Chen, {H. F.} and Tsai, {T. C.} and Lee, {T. Y.} and Yang, {Y. S.}",

note = "Funding Information: Received September 12, 1995; revised and accepted February 5,1996. * Supported in part by grants from the National Science Council (NSC-82-412-B002-343), Taipei, Taiwan. t Department of Obstetrics and Gynecology. :\: Reprint requests: Hong-Nerng Ho, M.D., Department of Obstetrics and Gynecology, National Taiwan University Hospital, No.7, Chung-Shan South Road, Taipei, Taiwan (FAX: 886-2-3418557). § Department of Urology. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "1996",

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doi = "10.1016/s0015-0282(16)58406-4",

language = "English",

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T1 - Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis

AU - Chen, S. U.

AU - Ho, H. N.

AU - Chen, H. F.

AU - Tsai, T. C.

AU - Lee, T. Y.

AU - Yang, Y. S.

N1 - Funding Information: Received September 12, 1995; revised and accepted February 5,1996. * Supported in part by grants from the National Science Council (NSC-82-412-B002-343), Taipei, Taiwan. t Department of Obstetrics and Gynecology. :\: Reprint requests: Hong-Nerng Ho, M.D., Department of Obstetrics and Gynecology, National Taiwan University Hospital, No.7, Chung-Shan South Road, Taipei, Taiwan (FAX: 886-2-3418557). § Department of Urology. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Objective: To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. Design: Clinical trial. Setting: Reproductive unit of a university teaching hospital. Patient: A patient of obstructive azoospermia with defective spermiogenesis. Intervention: Testicular biopsy after scrotal exploration and spermatid injection into the cytoplasm of oocyte. Main Outcome Measures: Fertilization and cleavage. Results: Four of 13 spermatid injections achieved normal fertilization and 2 of them cleaved. Conclusion: Intracytoplasmic spermatid injection may be a possible treatment for patients of defective spermiogenesis who have no viable spermatozoa available.

AB - Objective: To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. Design: Clinical trial. Setting: Reproductive unit of a university teaching hospital. Patient: A patient of obstructive azoospermia with defective spermiogenesis. Intervention: Testicular biopsy after scrotal exploration and spermatid injection into the cytoplasm of oocyte. Main Outcome Measures: Fertilization and cleavage. Results: Four of 13 spermatid injections achieved normal fertilization and 2 of them cleaved. Conclusion: Intracytoplasmic spermatid injection may be a possible treatment for patients of defective spermiogenesis who have no viable spermatozoa available.

KW - defective spermiogenesis

KW - Intracytoplasmic spermatid injection

KW - obstructive azoospermia

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Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis

Abstract

Keywords

ASJC Scopus subject areas

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