Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis

S. U. Chen; H. N. Ho; H. F. Chen; T. C. Tsai; T. Y. Lee; Y. S. Yang

Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis

S. U. Chen, H. N. Ho, H. F. Chen, T. C. Tsai, T. Y. Lee, Y. S. Yang

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. Design: Clinical trial. Setting: Reproductive unit of a university teaching hospital. Patient: A patient of obstructive azoospermia with defective spermiogenesis. Intervention: Testicular biopsy after scrotal exploration and spermatid injection into the cytoplasm of oocyte. Main Outcome Measures: Fertilization and cleavage. Results: Four of 13 spermatid injections achieved normal fertilization and 2 of them cleaved. Conclusion: Intracytoplasmic spermatid injection may be a possible treatment for patients of defective spermiogenesis who have no viable spermatozoa available.

Original language	English
Pages (from-to)	157-160
Number of pages	4
Journal	Fertility and Sterility
Volume	66
Issue number	1
Publication status	Published - Jan 1 1996
Externally published	Yes

Keywords

defective spermiogenesis
Intracytoplasmic spermatid injection
obstructive azoospermia

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynaecology

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AU - Ho, H. N.

AU - Chen, H. F.

AU - Tsai, T. C.

AU - Lee, T. Y.

AU - Yang, Y. S.

PY - 1996/1/1

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N2 - Objective: To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. Design: Clinical trial. Setting: Reproductive unit of a university teaching hospital. Patient: A patient of obstructive azoospermia with defective spermiogenesis. Intervention: Testicular biopsy after scrotal exploration and spermatid injection into the cytoplasm of oocyte. Main Outcome Measures: Fertilization and cleavage. Results: Four of 13 spermatid injections achieved normal fertilization and 2 of them cleaved. Conclusion: Intracytoplasmic spermatid injection may be a possible treatment for patients of defective spermiogenesis who have no viable spermatozoa available.

AB - Objective: To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. Design: Clinical trial. Setting: Reproductive unit of a university teaching hospital. Patient: A patient of obstructive azoospermia with defective spermiogenesis. Intervention: Testicular biopsy after scrotal exploration and spermatid injection into the cytoplasm of oocyte. Main Outcome Measures: Fertilization and cleavage. Results: Four of 13 spermatid injections achieved normal fertilization and 2 of them cleaved. Conclusion: Intracytoplasmic spermatid injection may be a possible treatment for patients of defective spermiogenesis who have no viable spermatozoa available.

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KW - Intracytoplasmic spermatid injection

KW - obstructive azoospermia

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