Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis

S. U. Chen, H. N. Ho, H. F. Chen, T. C. Tsai, T. Y. Lee, Y. S. Yang

Research output: Contribution to journalArticle

26 Citations (Scopus)


Objective: To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. Design: Clinical trial. Setting: Reproductive unit of a university teaching hospital. Patient: A patient of obstructive azoospermia with defective spermiogenesis. Intervention: Testicular biopsy after scrotal exploration and spermatid injection into the cytoplasm of oocyte. Main Outcome Measures: Fertilization and cleavage. Results: Four of 13 spermatid injections achieved normal fertilization and 2 of them cleaved. Conclusion: Intracytoplasmic spermatid injection may be a possible treatment for patients of defective spermiogenesis who have no viable spermatozoa available.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalFertility and Sterility
Issue number1
Publication statusPublished - Jan 1 1996
Externally publishedYes



  • defective spermiogenesis
  • Intracytoplasmic spermatid injection
  • obstructive azoospermia

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this