Fe and Zn co-substituted beta-tricalcium phosphate (β-TCP): Synthesis, structural, magnetic, mechanical and biological properties

Lauryna Sinusaite, Anton Popov, Andris Antuzevics, Kestutis Mazeika, Dalis Baltrunas, Jen Chang Yang, Jiun Lin Horng, Shengfang Shi, Tohru Sekino, Kunio Ishikawa, Aivaras Kareiva, Aleksej Zarkov

Research output: Contribution to journalArticle

Abstract

In the present work, Fe3+ and Zn2+ co-substituted β-tricalcium phosphate (β-TCP) has been synthesized by wet co-precipitation method. Co-substitution level in the range from 1 to 5 mol% has been studied. Thermal decomposition of as-prepared precipitates was shown to be affected by introducing of foreign ions, decreasing the decomposition temperature of precursor. It was determined that partial substitution of Ca2+ by Fe3+ and Zn2+ ions leads to the change in lattice parameters, which gradually decrease as doping level increases. Lattice distortion was also confirmed by means of Raman spectroscopy, which showed gradual change of the peaks shape in the Raman spectra. Rietveld refinement and electron paramagnetic resonance study confirmed that Fe3+ ions occupy only one Ca crystallographic site until Fe3+ and Zn2+ substitution level reaches 5 mol%. All co-substituted samples revealed paramagnetic behavior, magnetization of powders was determined to be linearly dependent on concentration of Fe3+ ions. Cytotoxicity of the synthesized species was estimated by in vivo assay using zebrafish (Danio rerio) and revealed non-toxic nature of the samples. Preparation of ceramic bodies from the powders was performed, however the results obtained on Vickers hardness of the ceramics did not show improvement in mechanical properties induced by co-substitution.

Original languageEnglish
Article number110918
JournalMaterials Science and Engineering C
Volume112
DOIs
Publication statusPublished - Jul 2020

Keywords

  • Beta-tricalcium phosphate
  • Cytotoxicity
  • Fe and Zn co-substitution
  • Magnetic properties
  • Structural analysis

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint Dive into the research topics of 'Fe and Zn co-substituted beta-tricalcium phosphate (β-TCP): Synthesis, structural, magnetic, mechanical and biological properties'. Together they form a unique fingerprint.

  • Cite this

    Sinusaite, L., Popov, A., Antuzevics, A., Mazeika, K., Baltrunas, D., Yang, J. C., Horng, J. L., Shi, S., Sekino, T., Ishikawa, K., Kareiva, A., & Zarkov, A. (2020). Fe and Zn co-substituted beta-tricalcium phosphate (β-TCP): Synthesis, structural, magnetic, mechanical and biological properties. Materials Science and Engineering C, 112, [110918]. https://doi.org/10.1016/j.msec.2020.110918