FDG PET or PET/CT for detecting intramedullary and extramedullary lesions in multiple myeloma: A systematic review and meta-analysis

Yu Yu Lu, Jin Hua Chen, Wan Yu Lin, Ji An Liang, Hsin Yi Wang, Shih Chuan Tsai, Chia Hung Kao

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Aim: The purpose of the current study was to conduct a systematic review and meta-analysis of the published literature to evaluate the diagnostic accuracy of FDG PET or PET/CT for intramedullary and extramedullary lesions in multiple myeloma. Methods: The authors conducted a systematic MEDLINE search of published articles. Two reviewers independently assessed the methodological quality of each study. We estimated pooled sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR-), and summary receiver operating characteristic curves in the detection of intramedullary and extramedullary lesions in multiple myeloma. Results: Fourteen studies with a total of 395 patients met the inclusion criteria. The pooled estimates of sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of FDG PET or PET/CT for the detection of extramedullary lesions in multiple myeloma were 96.0% [95% confidence interval (CI), 79.6%-99.9%], 77.8% (95% CI, 40.0%-97.2%), 3.28 (95% CI, 1.29-8.32), and 0.12 (95% CI, 0.03-0.42), respectively. The pooled estimates of sensitivity, specificity, LR+, and LR-of FDG PET or PET/CT for the detection of intramedullary lesions in multiple myeloma were 61.1% (95% CI, 43.5%-76.9%), 94.1% (95% CI, 71.3%-99.9%), 5.73 (95% CI, 1.53-21.40), and 0.43 (95% CI, 0.28-0.65), respectively. Conclusions: Whole-body FDG PET or PET/CT is a valuable imaging tool for the assessment of patients with multiple myeloma, especially for the appraisal of extramedullary involvement.

Original languageEnglish
Pages (from-to)833-837
Number of pages5
JournalClinical Nuclear Medicine
Volume37
Issue number9
DOIs
Publication statusPublished - Sep 2012
Externally publishedYes

Keywords

  • FDG PET
  • meta-analysis
  • multiple myeloma
  • PET/CT
  • systematic review

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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