Abstract

Abdominal pain is one of the key symptoms of irritable bowel syndrome (IBS). Studies have indicated an increase in the incidence of IBS in Asia. However, yet the pathophysiology of this disease remains unknown. Women are more likely to develop the condition than men, especially the constipation-predominant type. Essential fatty acid (EFA) malnutrition is one of several theories discussing the mechanism of IBS. The authors hypothesized that significant EFA deficiency may cause abdominal pain in patients with IBS. However, because patterns in the oral intake of EFAs differ between cultures, the authors narrowed this study to examine the nutritional status of Asian female patients with IBS The authors investigated Asian female patients with IBS and compared them with a group of healthy controls. Thirty patients with IBS and 39 healthy individuals were included in this study. The participants' age, height, weight, and waist size were recorded. The 24-item Hamilton Depression Rating Scale was documented. Both erythrocyte and plasma fatty acid content were analyzed through gas-liquid chromatography. The authors found that patients with IBS exhibited significantly higher scores for depression, higher proportions of plasma saturated fatty acids and monounsaturated fatty acids, and lower proportions of docosahexaenoic acid and total omega-3 polyunsaturated fatty acids in plasma are associated with IBS in Asian female patients. Further study is indicated to confirm the causality of this association.

Original languageEnglish
Article numbere9094
JournalMedicine (United States)
Volume96
Issue number49
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Irritable Bowel Syndrome
Fatty Acids
Essential Fatty Acids
Abdominal Pain
Monounsaturated Fatty Acids
Docosahexaenoic Acids
Omega-3 Fatty Acids
Constipation
Nutritional Status
Unsaturated Fatty Acids
Malnutrition
Causality
Gas Chromatography
Erythrocytes
Weights and Measures
Control Groups
Incidence

Keywords

  • docosahexaenoic acid
  • eicosapentaenoic acid
  • essential fatty acid
  • irritable bowel syndrome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fatty acid components in Asian female patients with irritable bowel syndrome. / Chua, Chian Sem; Huang, Shih Yi; Cheng, Chiao Wen; Bai, Chyi Huey; Hsu, Chien Yeh; Chiu, Hung Wen; Hsu, Jung Lung.

In: Medicine (United States), Vol. 96, No. 49, e9094, 01.12.2017.

Research output: Contribution to journalArticle

Chua, Chian Sem ; Huang, Shih Yi ; Cheng, Chiao Wen ; Bai, Chyi Huey ; Hsu, Chien Yeh ; Chiu, Hung Wen ; Hsu, Jung Lung. / Fatty acid components in Asian female patients with irritable bowel syndrome. In: Medicine (United States). 2017 ; Vol. 96, No. 49.
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