Fatal Aeromonas hydrophila bacteremia in a hemodialysis patient treated with deferoxamine

S. H. Lin, S. D. Shieh, Y. F. Lin, E. De Brauwer, H. W. Van Landuyt, B. Gordts, J. R. Boelaert

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Abstract

A 49-year-old woman undergoing long-term hemodialysis and treated with deferoxamine (DFO) 1.5 g twice weekly for aluminum bone disease developed fever and bilateral calf pain caused by myonecrosis with gas gangrene. She had a rapidly fatal outcome. The cultures of blood and aspirates from both calf muscles demonstrated Aeromonas hydrophila. No obvious entry point could tie traced. The in vitro growth of the patient's strain was found to be stimulated by the deferoxamine-iron complex in an iron-deprived medium. It is suggested that high-dose DFO therapy in this patient was responsible for promoting a bacterial infection by this microorganism.

Original languageEnglish
Pages (from-to)733-735
Number of pages3
JournalAmerican Journal of Kidney Diseases
Volume27
Issue number5
Publication statusPublished - 1996
Externally publishedYes

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Keywords

  • Aeromonas hydrophila
  • bacteremia
  • deferoxamine
  • hemodialysis
  • myonecrosis

ASJC Scopus subject areas

  • Nephrology

Cite this

Lin, S. H., Shieh, S. D., Lin, Y. F., De Brauwer, E., Van Landuyt, H. W., Gordts, B., & Boelaert, J. R. (1996). Fatal Aeromonas hydrophila bacteremia in a hemodialysis patient treated with deferoxamine. American Journal of Kidney Diseases, 27(5), 733-735.