Fasting serum leptin level correlateswith mid-arm fat area in peritoneal dialysis patients

Te Chao Fang, Chung Jen Lee, Chih Hsien Wang, Hung Hsiang Liou, Bang Gee Hsu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Leptin correlates with body fat content and plays a pivotal role in inflammatory response. This study aimed to investigate the relationships of fasting serum leptin levels and the anthropometric fat components among peritoneal dialysis (PD) patients. Fasting blood samples were obtained from 40 PD patients. Leptin levels were measured using a commercial enzyme-linked immunosorbent assay kit. Body weight (r = 0.424; P = 0.006), waist circumference (r = 0.352; P = 0.026), body mass index (BMI; r = 0.483; P = 0.002), body fat mass (r = 0.352; P = 0.026), high sensitivity C-reactive protein (hs-CRP; r = 0.494; P = 0.001), triceps skinfold thickness (TSF; r = 0.505; P = 0.001), mid-arm circumference (MAC; r = 0.471; P = 0.002), and mid-arm fat area (MAFA; r = 0.564; P <0.001) were positively correlated, while high density lipoprotein (HDL)-cholesterol (r = -0.345; P = 0.028) was negatively correlated with fasting serum leptin levels among the PD patients. Multivariate forward stepwise linear regression analysis showed that MAFA (R2 = 0.318, P = 0.011) was the independent predictor of fasting serum leptin levels among the PD patients. In conclusion, fasting leptin level was positively associated with body fat composition (body weight, waist circumference, BMI, body fat mass, TSF, MAC, and MAFA) and hs-CRP among PD patients, and MAFA was the independent predictor of fasting serum leptin levels among the PD patients.

Original languageEnglish
Pages (from-to)583-588
Number of pages6
JournalTherapeutic Apheresis and Dialysis
Volume14
Issue number6
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

Fingerprint

Peritoneal Dialysis
Leptin
Fasting
Fats
Serum
Adipose Tissue
Waist Circumference
Body Weight
Skinfold Thickness
Body Composition
C-Reactive Protein
HDL Cholesterol
Linear Models
Body Mass Index
Enzyme-Linked Immunosorbent Assay
Regression Analysis

Keywords

  • Leptin
  • Mid-arm fat area
  • Peritoneal dialysis

ASJC Scopus subject areas

  • Hematology
  • Nephrology

Cite this

Fasting serum leptin level correlateswith mid-arm fat area in peritoneal dialysis patients. / Fang, Te Chao; Lee, Chung Jen; Wang, Chih Hsien; Liou, Hung Hsiang; Hsu, Bang Gee.

In: Therapeutic Apheresis and Dialysis, Vol. 14, No. 6, 12.2010, p. 583-588.

Research output: Contribution to journalArticle

Fang, Te Chao ; Lee, Chung Jen ; Wang, Chih Hsien ; Liou, Hung Hsiang ; Hsu, Bang Gee. / Fasting serum leptin level correlateswith mid-arm fat area in peritoneal dialysis patients. In: Therapeutic Apheresis and Dialysis. 2010 ; Vol. 14, No. 6. pp. 583-588.
@article{2b2c5d716a6a4d0896d88b6ae0b8d734,
title = "Fasting serum leptin level correlateswith mid-arm fat area in peritoneal dialysis patients",
abstract = "Leptin correlates with body fat content and plays a pivotal role in inflammatory response. This study aimed to investigate the relationships of fasting serum leptin levels and the anthropometric fat components among peritoneal dialysis (PD) patients. Fasting blood samples were obtained from 40 PD patients. Leptin levels were measured using a commercial enzyme-linked immunosorbent assay kit. Body weight (r = 0.424; P = 0.006), waist circumference (r = 0.352; P = 0.026), body mass index (BMI; r = 0.483; P = 0.002), body fat mass (r = 0.352; P = 0.026), high sensitivity C-reactive protein (hs-CRP; r = 0.494; P = 0.001), triceps skinfold thickness (TSF; r = 0.505; P = 0.001), mid-arm circumference (MAC; r = 0.471; P = 0.002), and mid-arm fat area (MAFA; r = 0.564; P <0.001) were positively correlated, while high density lipoprotein (HDL)-cholesterol (r = -0.345; P = 0.028) was negatively correlated with fasting serum leptin levels among the PD patients. Multivariate forward stepwise linear regression analysis showed that MAFA (R2 = 0.318, P = 0.011) was the independent predictor of fasting serum leptin levels among the PD patients. In conclusion, fasting leptin level was positively associated with body fat composition (body weight, waist circumference, BMI, body fat mass, TSF, MAC, and MAFA) and hs-CRP among PD patients, and MAFA was the independent predictor of fasting serum leptin levels among the PD patients.",
keywords = "Leptin, Mid-arm fat area, Peritoneal dialysis",
author = "Fang, {Te Chao} and Lee, {Chung Jen} and Wang, {Chih Hsien} and Liou, {Hung Hsiang} and Hsu, {Bang Gee}",
year = "2010",
month = "12",
doi = "10.1111/j.1744-9987.2010.00847.x",
language = "English",
volume = "14",
pages = "583--588",
journal = "Therapeutic Apheresis and Dialysis",
issn = "1744-9979",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Fasting serum leptin level correlateswith mid-arm fat area in peritoneal dialysis patients

AU - Fang, Te Chao

AU - Lee, Chung Jen

AU - Wang, Chih Hsien

AU - Liou, Hung Hsiang

AU - Hsu, Bang Gee

PY - 2010/12

Y1 - 2010/12

N2 - Leptin correlates with body fat content and plays a pivotal role in inflammatory response. This study aimed to investigate the relationships of fasting serum leptin levels and the anthropometric fat components among peritoneal dialysis (PD) patients. Fasting blood samples were obtained from 40 PD patients. Leptin levels were measured using a commercial enzyme-linked immunosorbent assay kit. Body weight (r = 0.424; P = 0.006), waist circumference (r = 0.352; P = 0.026), body mass index (BMI; r = 0.483; P = 0.002), body fat mass (r = 0.352; P = 0.026), high sensitivity C-reactive protein (hs-CRP; r = 0.494; P = 0.001), triceps skinfold thickness (TSF; r = 0.505; P = 0.001), mid-arm circumference (MAC; r = 0.471; P = 0.002), and mid-arm fat area (MAFA; r = 0.564; P <0.001) were positively correlated, while high density lipoprotein (HDL)-cholesterol (r = -0.345; P = 0.028) was negatively correlated with fasting serum leptin levels among the PD patients. Multivariate forward stepwise linear regression analysis showed that MAFA (R2 = 0.318, P = 0.011) was the independent predictor of fasting serum leptin levels among the PD patients. In conclusion, fasting leptin level was positively associated with body fat composition (body weight, waist circumference, BMI, body fat mass, TSF, MAC, and MAFA) and hs-CRP among PD patients, and MAFA was the independent predictor of fasting serum leptin levels among the PD patients.

AB - Leptin correlates with body fat content and plays a pivotal role in inflammatory response. This study aimed to investigate the relationships of fasting serum leptin levels and the anthropometric fat components among peritoneal dialysis (PD) patients. Fasting blood samples were obtained from 40 PD patients. Leptin levels were measured using a commercial enzyme-linked immunosorbent assay kit. Body weight (r = 0.424; P = 0.006), waist circumference (r = 0.352; P = 0.026), body mass index (BMI; r = 0.483; P = 0.002), body fat mass (r = 0.352; P = 0.026), high sensitivity C-reactive protein (hs-CRP; r = 0.494; P = 0.001), triceps skinfold thickness (TSF; r = 0.505; P = 0.001), mid-arm circumference (MAC; r = 0.471; P = 0.002), and mid-arm fat area (MAFA; r = 0.564; P <0.001) were positively correlated, while high density lipoprotein (HDL)-cholesterol (r = -0.345; P = 0.028) was negatively correlated with fasting serum leptin levels among the PD patients. Multivariate forward stepwise linear regression analysis showed that MAFA (R2 = 0.318, P = 0.011) was the independent predictor of fasting serum leptin levels among the PD patients. In conclusion, fasting leptin level was positively associated with body fat composition (body weight, waist circumference, BMI, body fat mass, TSF, MAC, and MAFA) and hs-CRP among PD patients, and MAFA was the independent predictor of fasting serum leptin levels among the PD patients.

KW - Leptin

KW - Mid-arm fat area

KW - Peritoneal dialysis

UR - http://www.scopus.com/inward/record.url?scp=78651490666&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78651490666&partnerID=8YFLogxK

U2 - 10.1111/j.1744-9987.2010.00847.x

DO - 10.1111/j.1744-9987.2010.00847.x

M3 - Article

C2 - 21118367

AN - SCOPUS:78651490666

VL - 14

SP - 583

EP - 588

JO - Therapeutic Apheresis and Dialysis

JF - Therapeutic Apheresis and Dialysis

SN - 1744-9979

IS - 6

ER -