Fasting serum ghrelin level is associated with metabolic syndrome in pieritoneal dialysis patients

Chung Jen Lee, Yi Maun Subeq, Chih Hsien Wang, Ru Ping Lee, Te Chao Fang, Bang Gee Hsu

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Abstract

◆ Background: Serum ghrelin levels are elevated in uremic patients. However, no data are available on the relationship between metabolic syndrome and serum ghrelin levels in peritoneal dialysis (PD) patients. ◆ Methods: Metabolic syndrome and its components were defined using diagnostic criteria recommended by the International Diabetes Federation. Fasting serum samples were taken from 30 PD patients. Serum ghrelin levels were measured by using a commercial enzyme-linked immunosorbent assay kit. ◆ Results: Of the 30 PD patients, 53.3% (16/30) had metabolic syndrome. Fasting serum ghrelin corrected inversely with metabolic syndrome among these PDs patients (p = 0.002). By odds ratio (OR) analysis of metabolic syndrome and metabolic syndrome diagnostic criteria, the predictors for metabolic syndrome are fasting glucose [OR: 39.00; 95% confidence interval (CI): 3.80 to 399.85; p <0.001], triglycerides (OR: 37.50; 95% CI: 3.64 to 386.51;p <0.001), and waist circumference (OR: 4.20; 95% CI: 1.95 to 9.03; p <0.001). Univariate linear regression analysis showed that body weight (r=-0.461, p= 0.010), waist circumference (r= -0.390, p = 0.033), and body mass index (r = -0.438, p = 0.016) were negatively correlated with serum ghrelin, and serum high density lipoprotein [HDL (r=0.626, p2 change = 0.392; p <0.001) was the independent predictor of serum ghrelin in PD patients and explained 39.2% of the variance. ◆ Conclusions: These results indicate an inverse association between circulating fasting ghrelin and metabolic syndrome in PD patients. Serum HDL was associated with serum ghrelin among PD patients.

Original languageEnglish
JournalPeritoneal Dialysis International
Volume28
Issue numberSUPP. 3
Publication statusPublished - Jun 2008
Externally publishedYes

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Keywords

  • Ghrelin
  • Metabolic syndrome

ASJC Scopus subject areas

  • Nephrology

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