Fasting serum adiponectin level inversely correlates with metabolic syndrome in peritoneal dialysis patients

Chih Hsien Wang, Ji Hung Wang, Chung Jen Lee, Te Chao Fang, Hung Hsiang Liou, Bang Gee Hsu

Research output: Contribution to journalArticle

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Abstract

Background:Metabolic syndrome is a significant risk factor for cardiovascular disease and predicts hospitalization in peritoneal dialysis (PD) patients. An inverse association between circulating adiponectin and metabolic syndrome has been observed in humans. However, no data are available on the relationship between metabolic syndrome and serum adiponectin levels in PD patients. Method: Fasting blood samples were obtained from 47 PD patients and 47 subjects in an outpatient department were enrolled as a control group. Metabolic syndrome and its components were defined using diagnostic criteria from the International Diabetes Federation. Adiponectin levels were measured using a commercial enzyme immunoassay kit. Results: Twenty-seven of 47 PD patients (57.5%) had metabolic syndrome. PD patients had lower serum albumin (p <0.001) and higher serum adiponectin levels (p = 0.016), high-sensitivity C-reactive protein (p = 0.008), creatinine (p <0.001) and metabolic syndrome (p <0.001) than controls. The fasting adiponectin level inversely correlated with the metabolic syndrome in these PD patients (p = 0.006). Univariate linear regression analysis showed that the waist circumference (r = -0.304; p = 0.038), body mass index (r = -0.347; p = 0.017), body fat mass (r = -0.305; p = 0.037), white blood count (r = -0.631; p <0.001), triglyceride (TG; r = -0.526; p <0.001), and fasting glucose (r = -0.394; p = 0.006) were negatively correlated with the fasting serum adiponectin levels, while high-density lipoprotein-cholesterol (r = 0.443; p = 0.002) was positively correlated with the fasting serum adiponectin levels among the PD patients. Multivariate forward stepwise linear regression analysis of the significant variables showed that white blood count (R2 change = 0.398, p <0.001), and TG (R2 change = 0.118, p = 0.002) were the independent predictors of fasting serum adiponectin levels and explained 51.6% of variance. Conclusions: We observed that PD patients had higher metabolic syndrome than the general population and an inverse association was found between the circulating fasting adiponectin level and metabolic syndrome in PD patients. White blood count and TG were independent predictors of the serum adiponectin level among PD patients.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalBlood Purification
Volume30
Issue number1
DOIs
Publication statusPublished - Jul 2010
Externally publishedYes

Fingerprint

Adiponectin
Peritoneal Dialysis
Fasting
Serum
Linear Models
Regression Analysis
Waist Circumference
Immunoenzyme Techniques
Serum Albumin
C-Reactive Protein
HDL Cholesterol
Adipose Tissue
Creatinine
Triglycerides
Hospitalization
Body Mass Index
Outpatients
Cardiovascular Diseases
Glucose
Control Groups

Keywords

  • Adiponectin
  • Metabolic syndrome
  • Peritoneal dialysis

ASJC Scopus subject areas

  • Nephrology
  • Hematology

Cite this

Fasting serum adiponectin level inversely correlates with metabolic syndrome in peritoneal dialysis patients. / Wang, Chih Hsien; Wang, Ji Hung; Lee, Chung Jen; Fang, Te Chao; Liou, Hung Hsiang; Hsu, Bang Gee.

In: Blood Purification, Vol. 30, No. 1, 07.2010, p. 1-7.

Research output: Contribution to journalArticle

Wang, Chih Hsien ; Wang, Ji Hung ; Lee, Chung Jen ; Fang, Te Chao ; Liou, Hung Hsiang ; Hsu, Bang Gee. / Fasting serum adiponectin level inversely correlates with metabolic syndrome in peritoneal dialysis patients. In: Blood Purification. 2010 ; Vol. 30, No. 1. pp. 1-7.
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abstract = "Background:Metabolic syndrome is a significant risk factor for cardiovascular disease and predicts hospitalization in peritoneal dialysis (PD) patients. An inverse association between circulating adiponectin and metabolic syndrome has been observed in humans. However, no data are available on the relationship between metabolic syndrome and serum adiponectin levels in PD patients. Method: Fasting blood samples were obtained from 47 PD patients and 47 subjects in an outpatient department were enrolled as a control group. Metabolic syndrome and its components were defined using diagnostic criteria from the International Diabetes Federation. Adiponectin levels were measured using a commercial enzyme immunoassay kit. Results: Twenty-seven of 47 PD patients (57.5{\%}) had metabolic syndrome. PD patients had lower serum albumin (p <0.001) and higher serum adiponectin levels (p = 0.016), high-sensitivity C-reactive protein (p = 0.008), creatinine (p <0.001) and metabolic syndrome (p <0.001) than controls. The fasting adiponectin level inversely correlated with the metabolic syndrome in these PD patients (p = 0.006). Univariate linear regression analysis showed that the waist circumference (r = -0.304; p = 0.038), body mass index (r = -0.347; p = 0.017), body fat mass (r = -0.305; p = 0.037), white blood count (r = -0.631; p <0.001), triglyceride (TG; r = -0.526; p <0.001), and fasting glucose (r = -0.394; p = 0.006) were negatively correlated with the fasting serum adiponectin levels, while high-density lipoprotein-cholesterol (r = 0.443; p = 0.002) was positively correlated with the fasting serum adiponectin levels among the PD patients. Multivariate forward stepwise linear regression analysis of the significant variables showed that white blood count (R2 change = 0.398, p <0.001), and TG (R2 change = 0.118, p = 0.002) were the independent predictors of fasting serum adiponectin levels and explained 51.6{\%} of variance. Conclusions: We observed that PD patients had higher metabolic syndrome than the general population and an inverse association was found between the circulating fasting adiponectin level and metabolic syndrome in PD patients. White blood count and TG were independent predictors of the serum adiponectin level among PD patients.",
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T1 - Fasting serum adiponectin level inversely correlates with metabolic syndrome in peritoneal dialysis patients

AU - Wang, Chih Hsien

AU - Wang, Ji Hung

AU - Lee, Chung Jen

AU - Fang, Te Chao

AU - Liou, Hung Hsiang

AU - Hsu, Bang Gee

PY - 2010/7

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N2 - Background:Metabolic syndrome is a significant risk factor for cardiovascular disease and predicts hospitalization in peritoneal dialysis (PD) patients. An inverse association between circulating adiponectin and metabolic syndrome has been observed in humans. However, no data are available on the relationship between metabolic syndrome and serum adiponectin levels in PD patients. Method: Fasting blood samples were obtained from 47 PD patients and 47 subjects in an outpatient department were enrolled as a control group. Metabolic syndrome and its components were defined using diagnostic criteria from the International Diabetes Federation. Adiponectin levels were measured using a commercial enzyme immunoassay kit. Results: Twenty-seven of 47 PD patients (57.5%) had metabolic syndrome. PD patients had lower serum albumin (p <0.001) and higher serum adiponectin levels (p = 0.016), high-sensitivity C-reactive protein (p = 0.008), creatinine (p <0.001) and metabolic syndrome (p <0.001) than controls. The fasting adiponectin level inversely correlated with the metabolic syndrome in these PD patients (p = 0.006). Univariate linear regression analysis showed that the waist circumference (r = -0.304; p = 0.038), body mass index (r = -0.347; p = 0.017), body fat mass (r = -0.305; p = 0.037), white blood count (r = -0.631; p <0.001), triglyceride (TG; r = -0.526; p <0.001), and fasting glucose (r = -0.394; p = 0.006) were negatively correlated with the fasting serum adiponectin levels, while high-density lipoprotein-cholesterol (r = 0.443; p = 0.002) was positively correlated with the fasting serum adiponectin levels among the PD patients. Multivariate forward stepwise linear regression analysis of the significant variables showed that white blood count (R2 change = 0.398, p <0.001), and TG (R2 change = 0.118, p = 0.002) were the independent predictors of fasting serum adiponectin levels and explained 51.6% of variance. Conclusions: We observed that PD patients had higher metabolic syndrome than the general population and an inverse association was found between the circulating fasting adiponectin level and metabolic syndrome in PD patients. White blood count and TG were independent predictors of the serum adiponectin level among PD patients.

AB - Background:Metabolic syndrome is a significant risk factor for cardiovascular disease and predicts hospitalization in peritoneal dialysis (PD) patients. An inverse association between circulating adiponectin and metabolic syndrome has been observed in humans. However, no data are available on the relationship between metabolic syndrome and serum adiponectin levels in PD patients. Method: Fasting blood samples were obtained from 47 PD patients and 47 subjects in an outpatient department were enrolled as a control group. Metabolic syndrome and its components were defined using diagnostic criteria from the International Diabetes Federation. Adiponectin levels were measured using a commercial enzyme immunoassay kit. Results: Twenty-seven of 47 PD patients (57.5%) had metabolic syndrome. PD patients had lower serum albumin (p <0.001) and higher serum adiponectin levels (p = 0.016), high-sensitivity C-reactive protein (p = 0.008), creatinine (p <0.001) and metabolic syndrome (p <0.001) than controls. The fasting adiponectin level inversely correlated with the metabolic syndrome in these PD patients (p = 0.006). Univariate linear regression analysis showed that the waist circumference (r = -0.304; p = 0.038), body mass index (r = -0.347; p = 0.017), body fat mass (r = -0.305; p = 0.037), white blood count (r = -0.631; p <0.001), triglyceride (TG; r = -0.526; p <0.001), and fasting glucose (r = -0.394; p = 0.006) were negatively correlated with the fasting serum adiponectin levels, while high-density lipoprotein-cholesterol (r = 0.443; p = 0.002) was positively correlated with the fasting serum adiponectin levels among the PD patients. Multivariate forward stepwise linear regression analysis of the significant variables showed that white blood count (R2 change = 0.398, p <0.001), and TG (R2 change = 0.118, p = 0.002) were the independent predictors of fasting serum adiponectin levels and explained 51.6% of variance. Conclusions: We observed that PD patients had higher metabolic syndrome than the general population and an inverse association was found between the circulating fasting adiponectin level and metabolic syndrome in PD patients. White blood count and TG were independent predictors of the serum adiponectin level among PD patients.

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