Abstract

Ultraviolet (UV) induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Collagen, which is one of the main building blocks of human skin, is regulated by collagen synthesis and collagen breakdown. Autophagy was found to block the epidermal hyperproliferative response to UVB and may play a crucial role in preventing skin photoaging. In the present study, we investigated whether far-infrared (FIR) therapy can inhibit skin photoaging via UVB irradiation in NIH 3T3 mouse embryonic fibroblasts and SKH-1 hairless mice. We found that FIR treatment significantly increased procollagen type I through the induction of the TGF-β/Smad axis. Furthermore, UVB significantly enhanced the expression of matrix metalloproteinase-1 (MMP-1) and MMP-9. FIR inhibited UVB-induced MMP-1 and MMP-9. Treatment with FIR reversed UVB-decreased type I collagen. In addition, FIR induced autophagy by inhibiting the Akt/mTOR signaling pathway. In UVB-induced skin photoaging in a hairless mouse model, FIR treatment resulted in decreased skin thickness in UVB irradiated mice and inhibited the degradation of collagen fibers. Moreover, FIR can increase procollagen type I via the inhibition of MMP-9 and induction of TGF-β in skin tissues. Therefore, our study provides evidence for the beneficial effects of FIR exposure in a model of skin photoaging.

Original languageEnglish
Article numbere0174042
JournalPLoS One
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 1 2017

Fingerprint

photoaging
Skin Aging
Hairless Mouse
Fibroblasts
skin (animal)
fibroblasts
ultraviolet radiation
Skin
Infrared radiation
Collagen
Collagen Type I
Matrix Metalloproteinases
mice
collagen
Matrix Metalloproteinase 1
gelatinase B
Autophagy
interstitial collagenase
autophagy
Pigmentation

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice. / Chiu, Hui Wen; Chen, Cheng Hsien; Chen, Yi Jie; Hsu, Yung Ho.

In: PLoS One, Vol. 12, No. 3, e0174042, 01.03.2017.

Research output: Contribution to journalArticle

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