Cytogenic and immunologic studies were performed on 20 members of a family who had an increased susceptibility to carcinomas of the colon, uterus and of lymphoproliferative malignancy. Chromosomal abnormalities such as small G and/or long submetacentric marker chromosome and other aberrations were observed in members who had cancer as well as some asymptomatic siblings. In addition, impairment of T cell function was noted in many of the members suggesting that defective cell‐mediated immunity, which also may be genetically determined, played an important role in the expression of this disease.
|Number of pages||8|
|Publication status||Published - Jan 1 1977|
ASJC Scopus subject areas
- Cancer Research