Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies. II. Chromosomal and immunologic abnormalities

Ivan P. Law, Ariel C. Hollinshead, Jacqueline Whang‐Peng, Jack H. Dean, Robert K. Oldham, Ronald B. Herberman, Marvin C. Rhode

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Cytogenic and immunologic studies were performed on 20 members of a family who had an increased susceptibility to carcinomas of the colon, uterus and of lymphoproliferative malignancy. Chromosomal abnormalities such as small G and/or long submetacentric marker chromosome and other aberrations were observed in members who had cancer as well as some asymptomatic siblings. In addition, impairment of T cell function was noted in many of the members suggesting that defective cell‐mediated immunity, which also may be genetically determined, played an important role in the expression of this disease.

Original languageEnglish
Pages (from-to)1229-1236
Number of pages8
JournalCancer
Volume39
Issue number3
DOIs
Publication statusPublished - Jan 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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