Factors responsible for elevated plasma B-type natriuretic peptide levels in severe aortic stenosis: Comparison between elderly and younger patients

Shunsuke Sasaki, Masao Daimon, Takayuki Kawata, Sakiko Miyazaki, Ryoko Ichikawa, Masaki Maruyama, Shuo Ju Chiang, Keitaro Mahara, Hiroyuki Watanabe, Tetsuya Sumiyoshi, Hitonobu Tomoike, Hiroyuki Daida

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Elevated plasma B-type natriuretic peptide (BNP) is a predictor of outcome and helpful for risk stratification in aortic stenosis (AS). However, left ventricular (LV) diastolic dysfunction progresses with aging and may also influence plasma BNP levels in elderly patients. We hypothesized that plasma BNP levels may be influenced by age in severe AS, and that factors that affect the elevation of plasma BNP levels may be different between elderly and younger patients with AS. Methods: We performed echocardiography in 341 patients with severe AS [aortic valve area (AVA)2] and classified them into two groups by age (elderly ≥75 years old, n=201; younger patients

Original languageEnglish
Pages (from-to)476-481
Number of pages6
JournalJournal of Cardiology
Volume64
Issue number6
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Aortic stenosis
  • Cardiac function
  • Echocardiography
  • Plasma B-type natriuretic peptide

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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    Sasaki, S., Daimon, M., Kawata, T., Miyazaki, S., Ichikawa, R., Maruyama, M., Chiang, S. J., Mahara, K., Watanabe, H., Sumiyoshi, T., Tomoike, H., & Daida, H. (2014). Factors responsible for elevated plasma B-type natriuretic peptide levels in severe aortic stenosis: Comparison between elderly and younger patients. Journal of Cardiology, 64(6), 476-481. https://doi.org/10.1016/j.jjcc.2014.03.005