Factors related to corneal endothelial damage after phacoemulsification in eyes with occludable angles

Yu Chieh Ko, Catherine Jui ling Liu, Ling Ing Lau, Chih Wei Wu, Joe C. Chou, Wen-Ming Hsu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose: To evaluate the influence of preoperative variables and early postoperative intraocular pressure (IOP) on the loss of corneal endothelial cells after phacoemulsification in eyes with occludable angles. Setting: Taipei Veterans General Hospital, Taipei, Taiwan. Methods: Sixty patients with occludable angles having phacoemulsification were prospectively enrolled. Corneal endothelial cell evaluation was conducted preoperatively and 3 months postoperatively. Results: Three months postoperatively, the mean corneal endothelial cell density decreased by 14.5% ± 25.8% (SD) (P < .001). Greater corneal endothelial cell loss was associated with shorter axial length (AL) (P = .008), steeper anterior corneal curvature (P = .03), greater nuclear opalescence (P = .04), and higher IOP measured 4 to 8 hours after surgery (P = .04) and the following morning (P = .002). Multiple linear regression analysis identified AL and the IOP measured 4 to 8 hours after surgery as the best predictors of postoperative corneal endothelial cell loss after adjusting for nuclear opalescence and phacoemulsification time (R2 = 0.40, P = .001). Conclusions: The corneal endothelial cell loss after phacoemulsification in eyes with occludable angles was associated with preoperative AL measurement and postoperative IOP within 24 hours. To minimize corneal endothelial cell damage, it is critical to avoid an IOP spike during the early postoperative period and to exercise extreme caution intraoperatively in eyes with an AL less than 22.6 mm.

Original languageEnglish
Pages (from-to)46-51
Number of pages6
JournalJournal of Cataract and Refractive Surgery
Volume34
Issue number1
DOIs
Publication statusPublished - Jan 1 2008
Externally publishedYes

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Corneal Endothelial Cell Loss
Phacoemulsification
Intraocular Pressure
Endothelial Cells
Eye Axial Length
Veterans Hospitals
Taiwan
Postoperative Period
General Hospitals
Linear Models
Cell Count
Regression Analysis
Corneal Injuries
Exercise

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology
  • Sensory Systems

Cite this

Factors related to corneal endothelial damage after phacoemulsification in eyes with occludable angles. / Ko, Yu Chieh; Liu, Catherine Jui ling; Lau, Ling Ing; Wu, Chih Wei; Chou, Joe C.; Hsu, Wen-Ming.

In: Journal of Cataract and Refractive Surgery, Vol. 34, No. 1, 01.01.2008, p. 46-51.

Research output: Contribution to journalArticle

Ko, Yu Chieh ; Liu, Catherine Jui ling ; Lau, Ling Ing ; Wu, Chih Wei ; Chou, Joe C. ; Hsu, Wen-Ming. / Factors related to corneal endothelial damage after phacoemulsification in eyes with occludable angles. In: Journal of Cataract and Refractive Surgery. 2008 ; Vol. 34, No. 1. pp. 46-51.
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