Factors leading to obstructive granulation tissue formation after ultraflex stenting in benign tracheal narrowing

F. T. Chung, S. M. Lin, C. L. Chou, H. C. Chen, C. T. Yu, H. P. Kuo

Research output: Contribution to journalArticle

28 Citations (Scopus)


Background: This retrospective study aimed to determine the factors leading to obstructive granulation tissue formation after the placement of a self-expandable metallic stent (SEMS) in patients with benign tracheal disease. Methods: From 2001 to 2007, a total of 67 patients (age: 62.1±15.4 years; range: 2387 years) with benign tracheal disease received 75ultraflex SEMS in our institution. Results: There were 35 SEMSs complicated by obstructive granulation tissue formation out of the 75 stents placed in patients with tracheal disease, giving an incidence of 47.8% (32/67 patients). The median time until developing granulation tissue was 106 days (IQR, 46396). Structural airway obstruction prior to SEMS implantation independently predicted obstructive granulation tissue formation after SEMS implantation (odds ratio: 3.84; 95% CI: 1.018.7; p=0.04). Time to granulation tissue detection was shorter in patients with structural airway obstruction before SEMS implantation (structural airway obstruction vs. dynamic collapse airway: median [IQR] 95 [38224, n=26] vs. 396 days [73994, n=9]; p=0.02). Conclusions: Obstructive granulation tissue formation is not uncommon after SEMS implantation and structural airway obstruction prior to SEMS implantation is an independent predictor. Although SEMS implantation should be restricted to a select population, it may be placed in patients not suitable for surgical intervention or rigid bronchoscopy with anesthesia because of poor pulmonary function.

Original languageEnglish
Pages (from-to)102-107
Number of pages6
JournalThoracic and Cardiovascular Surgeon
Issue number2
Publication statusPublished - Mar 31 2010
Externally publishedYes



  • Benign tracheal stenosis
  • Obstructive granulation tissue
  • Selfexpandable metallic stents
  • Ultraflex

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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