Factors determining operative mortality of grade V blunt hepatic trauma

Ray Jade Chen, Jen Feng Fang, Being Chuan Lin, Yu Pao Hsu, Jung Liang Kao, Miin Fu Chen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Despite recent advances in the management of severe hepatic injuries, the operative mortality rate of grade V hepatic injuries still ranges from 67% to 80%. Grade V hepatic injuries involving the retrohepatic cava or main hepatic veins are almost always lethal, especially those from blunt trauma. The purpose of this study is to understand the risk factors determining operative mortality in grade V blunt hepatic trauma, and to try to improve the surgical management of these injuries. Methods: A retrospective study was conducted at a medical center that offers services including primary, secondary, and tertiary care. Forty-four patients with grade V blunt hepatic injuries were treated during a 6-year period from January 1, 1991, to December 31, 1996. The operative mortality was compared by a multivariate analysis. Results: Forty-four patients with grade V blunt hepatic injuries were identified. Seven patients had only parenchymal injuries, and the others had vascular and associated parenchymal injuries. Venorrhaphy was used in 37 patients; 29 were treated using a nonshunting approach, and 8 with an atriocaval shunt. The overall mortality rate was 68% (30 of 44), and liver-related mortality was 50% (22 of 44). Univariate analysis revealed that the significant variables affecting operative mortality were initial systolic blood pressure, initial base deficit, the Glasgow Coma Scale, injury type, number of resected segments, and total intraoperative blood loss. Based on forward stepping logistic regression analysis, patients with an initial base deficit of -6 mmol/L or less (relative risk = 17.3), and a total intraoperative blood loss of 5,000 mL or more (relative risk = 23.5) would, significantly, encounter a worsening prognosis. Conclusions: Initial base deficit and total intraoperative blood loss were the significant factors that determined operative mortality after grade V blunt hepatic trauma. We suggest that prompt resuscitation and expeditious and appropriate surgical management, to control operative blood loss, is the only way to reduce operative mortality in patients with grade V blunt hepatic trauma.

Original languageEnglish
Pages (from-to)886-891
Number of pages6
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume49
Issue number5
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Mortality
Liver
Wounds and Injuries
Nonpenetrating Wounds
Blood Pressure
Secondary Care
Glasgow Coma Scale
Hepatic Veins
Intraoperative Complications
Tertiary Healthcare
Resuscitation
Blood Vessels
Primary Health Care
Multivariate Analysis
Retrospective Studies
Logistic Models
Regression Analysis

Keywords

  • Base deficit
  • Blunt hepatic trauma
  • Grade V hepatic injury
  • Intraoperative blood loss
  • Operative mortality

ASJC Scopus subject areas

  • Surgery

Cite this

Chen, R. J., Fang, J. F., Lin, B. C., Hsu, Y. P., Kao, J. L., & Chen, M. F. (2000). Factors determining operative mortality of grade V blunt hepatic trauma. Journal of Trauma - Injury, Infection and Critical Care, 49(5), 886-891.

Factors determining operative mortality of grade V blunt hepatic trauma. / Chen, Ray Jade; Fang, Jen Feng; Lin, Being Chuan; Hsu, Yu Pao; Kao, Jung Liang; Chen, Miin Fu.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 49, No. 5, 2000, p. 886-891.

Research output: Contribution to journalArticle

Chen, Ray Jade ; Fang, Jen Feng ; Lin, Being Chuan ; Hsu, Yu Pao ; Kao, Jung Liang ; Chen, Miin Fu. / Factors determining operative mortality of grade V blunt hepatic trauma. In: Journal of Trauma - Injury, Infection and Critical Care. 2000 ; Vol. 49, No. 5. pp. 886-891.
@article{a8c57d32192447caae2c4a9dfdb35fb3,
title = "Factors determining operative mortality of grade V blunt hepatic trauma",
abstract = "Background: Despite recent advances in the management of severe hepatic injuries, the operative mortality rate of grade V hepatic injuries still ranges from 67{\%} to 80{\%}. Grade V hepatic injuries involving the retrohepatic cava or main hepatic veins are almost always lethal, especially those from blunt trauma. The purpose of this study is to understand the risk factors determining operative mortality in grade V blunt hepatic trauma, and to try to improve the surgical management of these injuries. Methods: A retrospective study was conducted at a medical center that offers services including primary, secondary, and tertiary care. Forty-four patients with grade V blunt hepatic injuries were treated during a 6-year period from January 1, 1991, to December 31, 1996. The operative mortality was compared by a multivariate analysis. Results: Forty-four patients with grade V blunt hepatic injuries were identified. Seven patients had only parenchymal injuries, and the others had vascular and associated parenchymal injuries. Venorrhaphy was used in 37 patients; 29 were treated using a nonshunting approach, and 8 with an atriocaval shunt. The overall mortality rate was 68{\%} (30 of 44), and liver-related mortality was 50{\%} (22 of 44). Univariate analysis revealed that the significant variables affecting operative mortality were initial systolic blood pressure, initial base deficit, the Glasgow Coma Scale, injury type, number of resected segments, and total intraoperative blood loss. Based on forward stepping logistic regression analysis, patients with an initial base deficit of -6 mmol/L or less (relative risk = 17.3), and a total intraoperative blood loss of 5,000 mL or more (relative risk = 23.5) would, significantly, encounter a worsening prognosis. Conclusions: Initial base deficit and total intraoperative blood loss were the significant factors that determined operative mortality after grade V blunt hepatic trauma. We suggest that prompt resuscitation and expeditious and appropriate surgical management, to control operative blood loss, is the only way to reduce operative mortality in patients with grade V blunt hepatic trauma.",
keywords = "Base deficit, Blunt hepatic trauma, Grade V hepatic injury, Intraoperative blood loss, Operative mortality",
author = "Chen, {Ray Jade} and Fang, {Jen Feng} and Lin, {Being Chuan} and Hsu, {Yu Pao} and Kao, {Jung Liang} and Chen, {Miin Fu}",
year = "2000",
language = "English",
volume = "49",
pages = "886--891",
journal = "Journal of Trauma and Acute Care Surgery",
issn = "2163-0755",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Factors determining operative mortality of grade V blunt hepatic trauma

AU - Chen, Ray Jade

AU - Fang, Jen Feng

AU - Lin, Being Chuan

AU - Hsu, Yu Pao

AU - Kao, Jung Liang

AU - Chen, Miin Fu

PY - 2000

Y1 - 2000

N2 - Background: Despite recent advances in the management of severe hepatic injuries, the operative mortality rate of grade V hepatic injuries still ranges from 67% to 80%. Grade V hepatic injuries involving the retrohepatic cava or main hepatic veins are almost always lethal, especially those from blunt trauma. The purpose of this study is to understand the risk factors determining operative mortality in grade V blunt hepatic trauma, and to try to improve the surgical management of these injuries. Methods: A retrospective study was conducted at a medical center that offers services including primary, secondary, and tertiary care. Forty-four patients with grade V blunt hepatic injuries were treated during a 6-year period from January 1, 1991, to December 31, 1996. The operative mortality was compared by a multivariate analysis. Results: Forty-four patients with grade V blunt hepatic injuries were identified. Seven patients had only parenchymal injuries, and the others had vascular and associated parenchymal injuries. Venorrhaphy was used in 37 patients; 29 were treated using a nonshunting approach, and 8 with an atriocaval shunt. The overall mortality rate was 68% (30 of 44), and liver-related mortality was 50% (22 of 44). Univariate analysis revealed that the significant variables affecting operative mortality were initial systolic blood pressure, initial base deficit, the Glasgow Coma Scale, injury type, number of resected segments, and total intraoperative blood loss. Based on forward stepping logistic regression analysis, patients with an initial base deficit of -6 mmol/L or less (relative risk = 17.3), and a total intraoperative blood loss of 5,000 mL or more (relative risk = 23.5) would, significantly, encounter a worsening prognosis. Conclusions: Initial base deficit and total intraoperative blood loss were the significant factors that determined operative mortality after grade V blunt hepatic trauma. We suggest that prompt resuscitation and expeditious and appropriate surgical management, to control operative blood loss, is the only way to reduce operative mortality in patients with grade V blunt hepatic trauma.

AB - Background: Despite recent advances in the management of severe hepatic injuries, the operative mortality rate of grade V hepatic injuries still ranges from 67% to 80%. Grade V hepatic injuries involving the retrohepatic cava or main hepatic veins are almost always lethal, especially those from blunt trauma. The purpose of this study is to understand the risk factors determining operative mortality in grade V blunt hepatic trauma, and to try to improve the surgical management of these injuries. Methods: A retrospective study was conducted at a medical center that offers services including primary, secondary, and tertiary care. Forty-four patients with grade V blunt hepatic injuries were treated during a 6-year period from January 1, 1991, to December 31, 1996. The operative mortality was compared by a multivariate analysis. Results: Forty-four patients with grade V blunt hepatic injuries were identified. Seven patients had only parenchymal injuries, and the others had vascular and associated parenchymal injuries. Venorrhaphy was used in 37 patients; 29 were treated using a nonshunting approach, and 8 with an atriocaval shunt. The overall mortality rate was 68% (30 of 44), and liver-related mortality was 50% (22 of 44). Univariate analysis revealed that the significant variables affecting operative mortality were initial systolic blood pressure, initial base deficit, the Glasgow Coma Scale, injury type, number of resected segments, and total intraoperative blood loss. Based on forward stepping logistic regression analysis, patients with an initial base deficit of -6 mmol/L or less (relative risk = 17.3), and a total intraoperative blood loss of 5,000 mL or more (relative risk = 23.5) would, significantly, encounter a worsening prognosis. Conclusions: Initial base deficit and total intraoperative blood loss were the significant factors that determined operative mortality after grade V blunt hepatic trauma. We suggest that prompt resuscitation and expeditious and appropriate surgical management, to control operative blood loss, is the only way to reduce operative mortality in patients with grade V blunt hepatic trauma.

KW - Base deficit

KW - Blunt hepatic trauma

KW - Grade V hepatic injury

KW - Intraoperative blood loss

KW - Operative mortality

UR - http://www.scopus.com/inward/record.url?scp=0033665372&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033665372&partnerID=8YFLogxK

M3 - Article

C2 - 11086781

AN - SCOPUS:0033665372

VL - 49

SP - 886

EP - 891

JO - Journal of Trauma and Acute Care Surgery

JF - Journal of Trauma and Acute Care Surgery

SN - 2163-0755

IS - 5

ER -