Factors associated with poor outcomes of continuous renal replacement therapy

Chih Chin Kao, Ju Yeh Yang, Likwang Chen, Chia Ter Chao, Yu Sen Peng, Chih Kang Chiang, Jenq Wen Huang, Kuan Yu Hung

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Continuous renal replacement therapy (CRRT) is one of the dialysis modalities for critically ill patients. Despite intensive dialysis care, a high mortality rate is found in these patients. Our objective was to investigate the factors associated with poor outcomes in these patients. We conducted a retrospective cohort study using the National Health Insurance Research Database. Records of critically ill patients who received CRRT between 2007 and 2011 were retrieved, and the patients were categorized into two groups: those with acute kidney injury (AKI) and those with history of end-stage renal disease (ESRD). Our primary and secondary outcomes were in-hospital mortality and long-term survival and non-renal recovery (long-term dialysis dependence), respectively, in the AKI group. We enrolled 15,453 patients, with 13,204 and 2249 in the AKI and ESRD groups, respectively. Overall, 66.5% patients died during hospitalization. In-hospital mortality did not differ significantly between groups (adjusted odds ratio, 0.93; 95% CI, 0.84-1.02). Age, chronic liver disease, and cancer history were identified as independent risk factors for in-hospital mortality in both groups. Hypertension was associated with higher risk of in-hospital mortality in patients with AKI. Age, coronary artery disease, and admission to the medical intensive care unit (MICU) were risk factors for long-term dialysis dependence in patients with AKI. Patients with AKI and ESRD have similarly poor outcomes after CRRT. Older age and presence of chronic liver disease and cancer were associated with higher mortality. Older age, presence of coronary artery disease, and admission to MICU were associated with lower renal recovery rate in patients with AKI.

Original languageEnglish
Article numbere0177759
JournalPLoS ONE
Volume12
Issue number5
DOIs
Publication statusPublished - May 1 2017

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Renal Replacement Therapy
kidneys
Dialysis
Acute Kidney Injury
therapeutics
dialysis
Hospital Mortality
Intensive care units
kidney diseases
Liver
Chronic Kidney Failure
liver neoplasms
Health insurance
liver diseases
Liver Neoplasms
Recovery
Critical Illness
Intensive Care Units
Liver Diseases
Coronary Artery Disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kao, C. C., Yang, J. Y., Chen, L., Chao, C. T., Peng, Y. S., Chiang, C. K., ... Hung, K. Y. (2017). Factors associated with poor outcomes of continuous renal replacement therapy. PLoS ONE, 12(5), [e0177759]. https://doi.org/10.1371/journal.pone.0177759

Factors associated with poor outcomes of continuous renal replacement therapy. / Kao, Chih Chin; Yang, Ju Yeh; Chen, Likwang; Chao, Chia Ter; Peng, Yu Sen; Chiang, Chih Kang; Huang, Jenq Wen; Hung, Kuan Yu.

In: PLoS ONE, Vol. 12, No. 5, e0177759, 01.05.2017.

Research output: Contribution to journalArticle

Kao, CC, Yang, JY, Chen, L, Chao, CT, Peng, YS, Chiang, CK, Huang, JW & Hung, KY 2017, 'Factors associated with poor outcomes of continuous renal replacement therapy', PLoS ONE, vol. 12, no. 5, e0177759. https://doi.org/10.1371/journal.pone.0177759
Kao, Chih Chin ; Yang, Ju Yeh ; Chen, Likwang ; Chao, Chia Ter ; Peng, Yu Sen ; Chiang, Chih Kang ; Huang, Jenq Wen ; Hung, Kuan Yu. / Factors associated with poor outcomes of continuous renal replacement therapy. In: PLoS ONE. 2017 ; Vol. 12, No. 5.
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