Factors associated with chronic musculoskeletal pain in patients with chronic kidney disease

Heng Jung Hsu, Chiung Hui Yen, Kuang Hung Hsu, I. Wen Wu, Chin Chan Lee, Ming Jui Hung, Chiao Yin Sun, Chia Chi Chou, Yung Chih Chen, Ming Fang Hsieh, Chun Yu Chen, Chiao Ying Hsu, Chi Jen Tsai, Mai Szu Wu

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Background: Chronic musculoskeletal (MS) pain is common in patients with chronic kidney disease (CKD) undergoing haemodialysis. However, epidemiological data for chronic MS pain and factors associated with chronic MS pain in patients with early- or late-stage CKD who are not undergoing dialysis are limited. Method. A cross-sectional study to evaluate the prevalence of chronic MS pain and factors associated with chronic MS pain in patients with early- and late-stage CKD who were not undergoing dialysis, was conducted. In addition, the distribution of pain severity among patients with different stages of CKD was evaluated. Results: Of the 456 CKD patients studied, 53.3% (n = 243/456) had chronic MS pain. Chronic MS pain was independently and significantly associated with hyperuricemia as co-morbidity, as well as with the calcium × phosphate product levels. In CKD patients with hyperuricemia, chronic MS pain showed a negative, independent significant association with diabetes mellitus as a co-morbidity (odds ratio: 0.413, p = 0.020). However, in the CKD patients without hyperuricemia as a co-morbidity, chronic MS pain showed an independent significant association with the calcium × phosphate product levels (odds ratio: 1.093, p = 0.027). Furthermore, stage-5 CKD patients seemed to experience more severe chronic MS pain than patients with other stages of CKD. Conclusion: Chronic MS pain is common in CKD patients. Chronic MS pain was independently and significantly associated with hyperuricemia as co-morbidity, and with the calcium × phosphate product levels in early- and late-stage CKD patients who were not on dialysis.

Original languageEnglish
Article number6
JournalBMC Nephrology
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 8 2014

Keywords

  • Chronic kidney disease
  • Chronic pain
  • Hyperuricemia
  • Musculoskeletal pain

ASJC Scopus subject areas

  • Nephrology

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