Factors affecting recurrence in node-negative advanced gastric cancer

Kuo Hung Huang, Jen Hao Chen, Chew Wun Wu, Su Shun Lo, Mao-Chih Hsieh, Anna F.Y. Li, Win Yiu Lui

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background and Aim: Prognostic factors of lymph node-negative gastric adenocarcinoma after curative resection have been discussed. Recurrent pattern of advanced lymph node-negative gastric cancer after curative resection has rarely been described. Methods: Recurrent sites and correlated clinicopathological factors of 372 patients with lymph node-negative advanced gastric adenocarcinoma that underwent R0 resection from 1988 to 2005 were analyzed. Results: Recurrence was noted in 51 (13.7%) patients. Recurrent rates according to site of recurrence were 26 peritoneal seeding (51.0%), 26 locoregional (51.0%), 17 hematogenous (33.3%), and 4 lymph node metastasis (7.8%). Clinicopathological factors to predict peritoneal seeding were serosal exposure, lymphovascular invasion, Lauren's diffuse type differentiation and scirrhous stromal reaction. Serosal exposure, tumor size, microscopic infiltrating growth type predicts locoregional recurrence. Tumor had only lymphovascular invasion predict hematogenous spreading. Conclusion: Node-negative advanced gastric cancer has more peritoneal seeding and locoregional recurrence. Aggressive cell behavior predicted the route of tumor cell spreading.

Original languageEnglish
Pages (from-to)1522-1526
Number of pages5
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume24
Issue number9
DOIs
Publication statusPublished - Jan 1 2009
Externally publishedYes

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Stomach Neoplasms
Lymph Nodes
Recurrence
Stomach
Adenocarcinoma
Neoplasms
Neoplasm Metastasis
Growth

Keywords

  • Advanced gastric adenocarcinoma
  • Node-negative
  • R0 resection
  • Recurrent pattern

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Factors affecting recurrence in node-negative advanced gastric cancer. / Huang, Kuo Hung; Chen, Jen Hao; Wu, Chew Wun; Lo, Su Shun; Hsieh, Mao-Chih; Li, Anna F.Y.; Lui, Win Yiu.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 24, No. 9, 01.01.2009, p. 1522-1526.

Research output: Contribution to journalArticle

Huang, Kuo Hung ; Chen, Jen Hao ; Wu, Chew Wun ; Lo, Su Shun ; Hsieh, Mao-Chih ; Li, Anna F.Y. ; Lui, Win Yiu. / Factors affecting recurrence in node-negative advanced gastric cancer. In: Journal of Gastroenterology and Hepatology (Australia). 2009 ; Vol. 24, No. 9. pp. 1522-1526.
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