Abstract
Background and Aim: Prognostic factors of lymph node-negative gastric adenocarcinoma after curative resection have been discussed. Recurrent pattern of advanced lymph node-negative gastric cancer after curative resection has rarely been described. Methods: Recurrent sites and correlated clinicopathological factors of 372 patients with lymph node-negative advanced gastric adenocarcinoma that underwent R0 resection from 1988 to 2005 were analyzed. Results: Recurrence was noted in 51 (13.7%) patients. Recurrent rates according to site of recurrence were 26 peritoneal seeding (51.0%), 26 locoregional (51.0%), 17 hematogenous (33.3%), and 4 lymph node metastasis (7.8%). Clinicopathological factors to predict peritoneal seeding were serosal exposure, lymphovascular invasion, Lauren's diffuse type differentiation and scirrhous stromal reaction. Serosal exposure, tumor size, microscopic infiltrating growth type predicts locoregional recurrence. Tumor had only lymphovascular invasion predict hematogenous spreading. Conclusion: Node-negative advanced gastric cancer has more peritoneal seeding and locoregional recurrence. Aggressive cell behavior predicted the route of tumor cell spreading.
| Original language | English |
|---|---|
| Pages (from-to) | 1522-1526 |
| Number of pages | 5 |
| Journal | Journal of Gastroenterology and Hepatology (Australia) |
| Volume | 24 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Jan 1 2009 |
| Externally published | Yes |
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Keywords
- Advanced gastric adenocarcinoma
- Node-negative
- R0 resection
- Recurrent pattern
ASJC Scopus subject areas
- Hepatology
- Gastroenterology
Cite this
Factors affecting recurrence in node-negative advanced gastric cancer. / Huang, Kuo Hung; Chen, Jen Hao; Wu, Chew Wun; Lo, Su Shun; Hsieh, Mao-Chih; Li, Anna F.Y.; Lui, Win Yiu.
In: Journal of Gastroenterology and Hepatology (Australia), Vol. 24, No. 9, 01.01.2009, p. 1522-1526.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Factors affecting recurrence in node-negative advanced gastric cancer
AU - Huang, Kuo Hung
AU - Chen, Jen Hao
AU - Wu, Chew Wun
AU - Lo, Su Shun
AU - Hsieh, Mao-Chih
AU - Li, Anna F.Y.
AU - Lui, Win Yiu
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Background and Aim: Prognostic factors of lymph node-negative gastric adenocarcinoma after curative resection have been discussed. Recurrent pattern of advanced lymph node-negative gastric cancer after curative resection has rarely been described. Methods: Recurrent sites and correlated clinicopathological factors of 372 patients with lymph node-negative advanced gastric adenocarcinoma that underwent R0 resection from 1988 to 2005 were analyzed. Results: Recurrence was noted in 51 (13.7%) patients. Recurrent rates according to site of recurrence were 26 peritoneal seeding (51.0%), 26 locoregional (51.0%), 17 hematogenous (33.3%), and 4 lymph node metastasis (7.8%). Clinicopathological factors to predict peritoneal seeding were serosal exposure, lymphovascular invasion, Lauren's diffuse type differentiation and scirrhous stromal reaction. Serosal exposure, tumor size, microscopic infiltrating growth type predicts locoregional recurrence. Tumor had only lymphovascular invasion predict hematogenous spreading. Conclusion: Node-negative advanced gastric cancer has more peritoneal seeding and locoregional recurrence. Aggressive cell behavior predicted the route of tumor cell spreading.
AB - Background and Aim: Prognostic factors of lymph node-negative gastric adenocarcinoma after curative resection have been discussed. Recurrent pattern of advanced lymph node-negative gastric cancer after curative resection has rarely been described. Methods: Recurrent sites and correlated clinicopathological factors of 372 patients with lymph node-negative advanced gastric adenocarcinoma that underwent R0 resection from 1988 to 2005 were analyzed. Results: Recurrence was noted in 51 (13.7%) patients. Recurrent rates according to site of recurrence were 26 peritoneal seeding (51.0%), 26 locoregional (51.0%), 17 hematogenous (33.3%), and 4 lymph node metastasis (7.8%). Clinicopathological factors to predict peritoneal seeding were serosal exposure, lymphovascular invasion, Lauren's diffuse type differentiation and scirrhous stromal reaction. Serosal exposure, tumor size, microscopic infiltrating growth type predicts locoregional recurrence. Tumor had only lymphovascular invasion predict hematogenous spreading. Conclusion: Node-negative advanced gastric cancer has more peritoneal seeding and locoregional recurrence. Aggressive cell behavior predicted the route of tumor cell spreading.
KW - Advanced gastric adenocarcinoma
KW - Node-negative
KW - R0 resection
KW - Recurrent pattern
UR - http://www.scopus.com/inward/record.url?scp=69949151458&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69949151458&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1746.2009.05844.x
DO - 10.1111/j.1440-1746.2009.05844.x
M3 - Article
VL - 24
SP - 1522
EP - 1526
JO - Journal of Gastroenterology and Hepatology (Australia)
JF - Journal of Gastroenterology and Hepatology (Australia)
SN - 0815-9319
IS - 9
ER -