Facial telangiectasia - An unusual complication of neonatal lupus erythematosus: Report of one case

Sheng-Chieh Lin, Shyh-Dar Shyur, Jiunn-Yi Wu, Li-Hsin Huang, Yi-Chun Ma

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Neonatal lupus erythematosus (NLE) is an uncommon passive autoimmune disease caused by transplacental passage of anti-Ro/SSA and/or anti-La/SSB or anti-U1RNP maternal autoantibodies. Common clinical manifestations include cutaneous lupus lesions, cardiac disease, notably congenital heart block, hematologic abnormalities, and hepatobiliary disease. The cutaneous lesions of NLE are usually transient, disappearing about six months after birth when maternal antibodies disappear from the infant's circulation. Persistent telangiectasia is a rare complication of NLE. We report a 3-year-old female who had cutaneous lupus with persistent facial telangiectasias over the frontal area. She was diagnosed with NLE at 2 months of age. Her findings then included cutaneous lupus, hemolytic anemia, a high titer of antinuclear antibodies (1:640) with a speckled pattern, positive anti-Ro/SSA and anti-La/SSB antibodies, and absence of anti-dsDNA antibodies. Her mother had systemic lupus erythematosus with the presence of high titer of antinuclear antibodies (1:1260) with a speckled pattern and positive anti-Ro/SSA and anti-La/SSB antibodies. The child's cutaneous lupus and hemolytic anemia disappeared at 6 months of age, but the telangiectasia persisted.
Original languageEnglish
Pages (from-to)246-248
Number of pages3
JournalActa Paediatrica Taiwanica
Volume45
Issue number4
Publication statusPublished - 2004
Externally publishedYes

Fingerprint

Telangiectasis
Skin
Antinuclear Antibodies
Hemolytic Anemia
Mothers
Antibodies
Systemic Lupus Erythematosus
Autoantibodies
Autoimmune Diseases
Anti-Idiotypic Antibodies
Heart Diseases
Neonatal Systemic lupus erythematosus
Parturition

Keywords

  • Hemolytic anemia
  • Neonatal lupus erythematosus
  • Telangiectasia
  • antinuclear antibody
  • corticosteroid
  • double stranded DNA
  • double stranded DNA antibody
  • La antibody
  • maternal antibody
  • Ro antibody
  • small nuclear ribonucleoprotein
  • unclassified drug
  • antibody titer
  • article
  • autoimmune disease
  • case report
  • clinical feature
  • congenital heart block
  • facial telangiectasia
  • female
  • fetomaternal transfusion
  • heart disease
  • hematologic disease
  • hemolytic anemia
  • hepatobiliary disease
  • human
  • human tissue
  • lupus erythematosus
  • newborn disease
  • newborn lupus erythematosus
  • preschool child
  • rare disease
  • skin lupus erythematosus
  • systemic lupus erythematosus
  • telangiectasia
  • Antibodies, Antinuclear
  • Diagnosis, Differential
  • Face
  • Family Health
  • Female
  • Humans
  • Infant
  • Lupus Erythematosus, Cutaneous
  • Telangiectasis

Cite this

Facial telangiectasia - An unusual complication of neonatal lupus erythematosus: Report of one case. / Lin, Sheng-Chieh; Shyur, Shyh-Dar; Wu, Jiunn-Yi; Huang, Li-Hsin; Ma, Yi-Chun.

In: Acta Paediatrica Taiwanica, Vol. 45, No. 4, 2004, p. 246-248.

Research output: Contribution to journalArticle

Lin, Sheng-Chieh ; Shyur, Shyh-Dar ; Wu, Jiunn-Yi ; Huang, Li-Hsin ; Ma, Yi-Chun. / Facial telangiectasia - An unusual complication of neonatal lupus erythematosus: Report of one case. In: Acta Paediatrica Taiwanica. 2004 ; Vol. 45, No. 4. pp. 246-248.
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abstract = "Neonatal lupus erythematosus (NLE) is an uncommon passive autoimmune disease caused by transplacental passage of anti-Ro/SSA and/or anti-La/SSB or anti-U1RNP maternal autoantibodies. Common clinical manifestations include cutaneous lupus lesions, cardiac disease, notably congenital heart block, hematologic abnormalities, and hepatobiliary disease. The cutaneous lesions of NLE are usually transient, disappearing about six months after birth when maternal antibodies disappear from the infant's circulation. Persistent telangiectasia is a rare complication of NLE. We report a 3-year-old female who had cutaneous lupus with persistent facial telangiectasias over the frontal area. She was diagnosed with NLE at 2 months of age. Her findings then included cutaneous lupus, hemolytic anemia, a high titer of antinuclear antibodies (1:640) with a speckled pattern, positive anti-Ro/SSA and anti-La/SSB antibodies, and absence of anti-dsDNA antibodies. Her mother had systemic lupus erythematosus with the presence of high titer of antinuclear antibodies (1:1260) with a speckled pattern and positive anti-Ro/SSA and anti-La/SSB antibodies. The child's cutaneous lupus and hemolytic anemia disappeared at 6 months of age, but the telangiectasia persisted.",
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author = "Sheng-Chieh Lin and Shyh-Dar Shyur and Jiunn-Yi Wu and Li-Hsin Huang and Yi-Chun Ma",
note = "被引用次數:3 Export Date: 7 April 2016 CODEN: TEYZF 通訊地址: Shyur, S.-D.; Department of Pediatrics, Mackay Memorial Hospital, No. 92, Chung-Shan N. Road, Taipei 104, Taiwan 化學物質/CAS: Antibodies, Antinuclear 參考文獻: Dorner, T., Feist, E., Pruss, A., Chaoui, R., Goldner, B., Hiepe, F., Significance of autoantibodies in neonatal lupus erythematosus (2000) Int Arch Allergy Immunol, 123, pp. 58-66; McCuistion, C.H., Schoch, E.P., Possible discoid lupus erythematosus in a newborn infant (1954) Arch Dermatol, 70, pp. 782-785; Le Thi Houng, D., Wechsler, B., Piette, J.C., Bletry, O., Godean, P., Pregnancy and its outcome in systemic lupus erythematosus (1994) Q J Med, 87, pp. 721-729; Silverman, E.D., Laxer, R.M., Neonatal lupus erythematosus (1997) Rheum Dis Clin North Am, 23, pp. 599-618; Vonderheid, E.C., Koblenzer, P.J., Ming, P.M., Neonatal lupus erythematosus: Report of four cases with review of the literature (1976) Arch Dermatol, 112, pp. 698-705; Bourke, J.F., Burns, D.A., Neonatal lupus erythematosus with persistent telangiectasia and spastic paraparesis (1993) Clin Exp Dermatol, 18, pp. 271-273; Cortran, R.S., Kumar, V., Robbins, S.L., (1989) Robbins' Pathologic Basis of Disease, 4th Ed., p. 590. , Philadelphia: WB Saunders; Thornton, C.M., Eichenfield, L.F., Shinall, E.A., Cutaneous telangiectases in neonatal lupus erythematosus (1995) J Am Acad Dermatol, 33, pp. 19-25; Neiman, A.R., Lee, L.A., Weston, W.L., Buyon, J.P., Cutaneous manifestations of neonatal lupus without heart block: Characteristics of mothers and children enrolled in a national registry (2000) J Pediatr, 137, pp. 674-680; Burch, J.M., Lee, L.A., Weston, W.L., Neonatal lupus erythematosus (2002) Dermatol Nur, 14, pp. 157-160; Carrascosa, J.M., Ribera, M., Bielsa, I., Coroleu, W., Ferrandiz, C., Cutis marmorata telangiectatica congenita or neonatal lupus? (1996) Pediatr Dermatol, 13, pp. 230-232; Prendiville, J.S., Cabral, D.A., Poskitt, J., Sargent, M.A., Central nervous system involvement in neonatal lupus erythematosus (2003) Pediatr Dermatol, 20, pp. 60-67; Goldman, M.P., Weiss, R.A., Brody, H.J., Treatment of facial telangiectasia with sclerotherapy, laser surgery, and/or electrodessication: A review (1993) J Dermatol Surg Oncol, 19, pp. 899-906; Buyon, J.P., Hiebert, R., Copel, J., Autoimmune-associated congenital heart block: Demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry (1998) J Am Coll Cardiol, 31, pp. 1658-1666",
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TY - JOUR

T1 - Facial telangiectasia - An unusual complication of neonatal lupus erythematosus: Report of one case

AU - Lin, Sheng-Chieh

AU - Shyur, Shyh-Dar

AU - Wu, Jiunn-Yi

AU - Huang, Li-Hsin

AU - Ma, Yi-Chun

N1 - 被引用次數:3 Export Date: 7 April 2016 CODEN: TEYZF 通訊地址: Shyur, S.-D.; Department of Pediatrics, Mackay Memorial Hospital, No. 92, Chung-Shan N. Road, Taipei 104, Taiwan 化學物質/CAS: Antibodies, Antinuclear 參考文獻: Dorner, T., Feist, E., Pruss, A., Chaoui, R., Goldner, B., Hiepe, F., Significance of autoantibodies in neonatal lupus erythematosus (2000) Int Arch Allergy Immunol, 123, pp. 58-66; McCuistion, C.H., Schoch, E.P., Possible discoid lupus erythematosus in a newborn infant (1954) Arch Dermatol, 70, pp. 782-785; Le Thi Houng, D., Wechsler, B., Piette, J.C., Bletry, O., Godean, P., Pregnancy and its outcome in systemic lupus erythematosus (1994) Q J Med, 87, pp. 721-729; Silverman, E.D., Laxer, R.M., Neonatal lupus erythematosus (1997) Rheum Dis Clin North Am, 23, pp. 599-618; Vonderheid, E.C., Koblenzer, P.J., Ming, P.M., Neonatal lupus erythematosus: Report of four cases with review of the literature (1976) Arch Dermatol, 112, pp. 698-705; Bourke, J.F., Burns, D.A., Neonatal lupus erythematosus with persistent telangiectasia and spastic paraparesis (1993) Clin Exp Dermatol, 18, pp. 271-273; Cortran, R.S., Kumar, V., Robbins, S.L., (1989) Robbins' Pathologic Basis of Disease, 4th Ed., p. 590. , Philadelphia: WB Saunders; Thornton, C.M., Eichenfield, L.F., Shinall, E.A., Cutaneous telangiectases in neonatal lupus erythematosus (1995) J Am Acad Dermatol, 33, pp. 19-25; Neiman, A.R., Lee, L.A., Weston, W.L., Buyon, J.P., Cutaneous manifestations of neonatal lupus without heart block: Characteristics of mothers and children enrolled in a national registry (2000) J Pediatr, 137, pp. 674-680; Burch, J.M., Lee, L.A., Weston, W.L., Neonatal lupus erythematosus (2002) Dermatol Nur, 14, pp. 157-160; Carrascosa, J.M., Ribera, M., Bielsa, I., Coroleu, W., Ferrandiz, C., Cutis marmorata telangiectatica congenita or neonatal lupus? (1996) Pediatr Dermatol, 13, pp. 230-232; Prendiville, J.S., Cabral, D.A., Poskitt, J., Sargent, M.A., Central nervous system involvement in neonatal lupus erythematosus (2003) Pediatr Dermatol, 20, pp. 60-67; Goldman, M.P., Weiss, R.A., Brody, H.J., Treatment of facial telangiectasia with sclerotherapy, laser surgery, and/or electrodessication: A review (1993) J Dermatol Surg Oncol, 19, pp. 899-906; Buyon, J.P., Hiebert, R., Copel, J., Autoimmune-associated congenital heart block: Demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry (1998) J Am Coll Cardiol, 31, pp. 1658-1666

PY - 2004

Y1 - 2004

N2 - Neonatal lupus erythematosus (NLE) is an uncommon passive autoimmune disease caused by transplacental passage of anti-Ro/SSA and/or anti-La/SSB or anti-U1RNP maternal autoantibodies. Common clinical manifestations include cutaneous lupus lesions, cardiac disease, notably congenital heart block, hematologic abnormalities, and hepatobiliary disease. The cutaneous lesions of NLE are usually transient, disappearing about six months after birth when maternal antibodies disappear from the infant's circulation. Persistent telangiectasia is a rare complication of NLE. We report a 3-year-old female who had cutaneous lupus with persistent facial telangiectasias over the frontal area. She was diagnosed with NLE at 2 months of age. Her findings then included cutaneous lupus, hemolytic anemia, a high titer of antinuclear antibodies (1:640) with a speckled pattern, positive anti-Ro/SSA and anti-La/SSB antibodies, and absence of anti-dsDNA antibodies. Her mother had systemic lupus erythematosus with the presence of high titer of antinuclear antibodies (1:1260) with a speckled pattern and positive anti-Ro/SSA and anti-La/SSB antibodies. The child's cutaneous lupus and hemolytic anemia disappeared at 6 months of age, but the telangiectasia persisted.

AB - Neonatal lupus erythematosus (NLE) is an uncommon passive autoimmune disease caused by transplacental passage of anti-Ro/SSA and/or anti-La/SSB or anti-U1RNP maternal autoantibodies. Common clinical manifestations include cutaneous lupus lesions, cardiac disease, notably congenital heart block, hematologic abnormalities, and hepatobiliary disease. The cutaneous lesions of NLE are usually transient, disappearing about six months after birth when maternal antibodies disappear from the infant's circulation. Persistent telangiectasia is a rare complication of NLE. We report a 3-year-old female who had cutaneous lupus with persistent facial telangiectasias over the frontal area. She was diagnosed with NLE at 2 months of age. Her findings then included cutaneous lupus, hemolytic anemia, a high titer of antinuclear antibodies (1:640) with a speckled pattern, positive anti-Ro/SSA and anti-La/SSB antibodies, and absence of anti-dsDNA antibodies. Her mother had systemic lupus erythematosus with the presence of high titer of antinuclear antibodies (1:1260) with a speckled pattern and positive anti-Ro/SSA and anti-La/SSB antibodies. The child's cutaneous lupus and hemolytic anemia disappeared at 6 months of age, but the telangiectasia persisted.

KW - Hemolytic anemia

KW - Neonatal lupus erythematosus

KW - Telangiectasia

KW - antinuclear antibody

KW - corticosteroid

KW - double stranded DNA

KW - double stranded DNA antibody

KW - La antibody

KW - maternal antibody

KW - Ro antibody

KW - small nuclear ribonucleoprotein

KW - unclassified drug

KW - antibody titer

KW - article

KW - autoimmune disease

KW - case report

KW - clinical feature

KW - congenital heart block

KW - facial telangiectasia

KW - female

KW - fetomaternal transfusion

KW - heart disease

KW - hematologic disease

KW - hemolytic anemia

KW - hepatobiliary disease

KW - human

KW - human tissue

KW - lupus erythematosus

KW - newborn disease

KW - newborn lupus erythematosus

KW - preschool child

KW - rare disease

KW - skin lupus erythematosus

KW - systemic lupus erythematosus

KW - telangiectasia

KW - Antibodies, Antinuclear

KW - Diagnosis, Differential

KW - Face

KW - Family Health

KW - Female

KW - Humans

KW - Infant

KW - Lupus Erythematosus, Cutaneous

KW - Telangiectasis

M3 - Article

VL - 45

SP - 246

EP - 248

JO - Pediatrics and Neonatology

JF - Pediatrics and Neonatology

SN - 1875-9572

IS - 4

ER -