Fabrication of ordered metallic glass nanotube arrays for label-free biosensing with diffractive reflectance

Wei Ting Chen, Shao Sian Li, Jinn P. Chu, Kuei Chih Feng, Jem Kun Chen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In this study, a photoresist template with well-defined contact hole array was fabricated, to which radio frequency magnetron sputtering process was then applied to deposit an alloyed Zr55Cu30Al10Ni5 target, and finally resulted in ordered metallic glass nanotube (MGNT) arrays after removal of the photoresist template. The thickness of the MGNT walls increased from 98 to 126 nm upon increasing the deposition time from 225 to 675 s. The wall thickness of the MGNT arrays also increased while the dimensions of MGNT reduced under the same deposition condition. The MGNT could be filled with biomacromolecules to change the effective refractive index. The air fraction of the medium layer were evaluated through static water contact angle measurements and, thereby, the effective refractive indices the transverse magnetic (TM) and transverse electric (TE) polarized modes were calculated. A standard biotin–streptavidin affinity model was tested using the MGNT arrays and the fundamental response of the system was investigated. Results show that filling the MGNT with streptavidin altered the effective refractive index of the layer, the angle of reflectance and color changes identified by an L*a*b* color space and color circle on an a*b* chromaticity diagram. The limit of detection (LOD) of the MGNT arrays for detection of streptavidin was estimated as 25 nM, with a detection time of 10 min. Thus, the MGNT arrays may be used as a versatile platform for high-sensitive label-free optical biosensing.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalBiosensors and Bioelectronics
Volume102
DOIs
Publication statusPublished - Apr 15 2018

Fingerprint

Nanotubes
Metallic glass
Glass
Labels
Fabrication
Refractometry
Refractive index
Streptavidin
Color
Photoresists
Angle measurement
Radio
Magnetron sputtering
Contact angle
Limit of Detection
Deposits
Air
Water

Keywords

  • Grating
  • Metallic glass
  • Nanotube
  • Ordered structure

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

Cite this

Fabrication of ordered metallic glass nanotube arrays for label-free biosensing with diffractive reflectance. / Chen, Wei Ting; Li, Shao Sian; Chu, Jinn P.; Feng, Kuei Chih; Chen, Jem Kun.

In: Biosensors and Bioelectronics, Vol. 102, 15.04.2018, p. 129-135.

Research output: Contribution to journalArticle

Chen, Wei Ting ; Li, Shao Sian ; Chu, Jinn P. ; Feng, Kuei Chih ; Chen, Jem Kun. / Fabrication of ordered metallic glass nanotube arrays for label-free biosensing with diffractive reflectance. In: Biosensors and Bioelectronics. 2018 ; Vol. 102. pp. 129-135.
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