Abstract

The aim of this study was to incorporate nanoscale Fe3O4 particles into a poly-L-lactide (PLLA) matrix to fabricate a magnetic and biodegradable composite. The physical and osteogenic functions of this material were tested. Injection molding was used to fabricate four nano-Fe3O4/PLLA composites with Fe3O4 mix ratios of 0%, 20%, 30%, and 40% (w/w). X-ray diffraction and hysteresis loop tests were performed to evaluate the physical properties of the nano-Fe3O4/PLLA composites. Tensile strength tests showed that the progressive addition of nano-Fe3O4 particles to the PLLA matrix results in higher elastic modulus and lower tensile strength. Images from scanning electron microscopy demonstrated that osteoblasts cultured on the 20% nano-Fe3O4/PLLA surface exhibited abundant filaments, which are a morphologic characteristic of osteoblastic differentiation. These results suggest that the 20% nano-Fe3O4/PLLA composite used in this study has the potential for future tissue engineering applications.

Original languageEnglish
JournalPolymer Composites
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Tissue engineering
Bone
Fabrication
Composite materials
Tensile strength
Osteoblasts
Bioelectric potentials
Hysteresis loops
Injection molding
Physical properties
Elastic moduli
X ray diffraction
Scanning electron microscopy
poly(lactide)

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry
  • Ceramics and Composites
  • Chemistry(all)

Cite this

Fabrication of Fe3O4/PLLA composites for use in bone tissue engineering. / Pan, Yu Hwa; Wang, Hsin Ta; Wu, Ting Lin; Fan, Kang Hsin; Huang, Haw Ming; Chang, Wei Jen.

In: Polymer Composites, 2016.

Research output: Contribution to journalArticle

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abstract = "The aim of this study was to incorporate nanoscale Fe3O4 particles into a poly-L-lactide (PLLA) matrix to fabricate a magnetic and biodegradable composite. The physical and osteogenic functions of this material were tested. Injection molding was used to fabricate four nano-Fe3O4/PLLA composites with Fe3O4 mix ratios of 0{\%}, 20{\%}, 30{\%}, and 40{\%} (w/w). X-ray diffraction and hysteresis loop tests were performed to evaluate the physical properties of the nano-Fe3O4/PLLA composites. Tensile strength tests showed that the progressive addition of nano-Fe3O4 particles to the PLLA matrix results in higher elastic modulus and lower tensile strength. Images from scanning electron microscopy demonstrated that osteoblasts cultured on the 20{\%} nano-Fe3O4/PLLA surface exhibited abundant filaments, which are a morphologic characteristic of osteoblastic differentiation. These results suggest that the 20{\%} nano-Fe3O4/PLLA composite used in this study has the potential for future tissue engineering applications.",
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AU - Huang, Haw Ming

AU - Chang, Wei Jen

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