Fabrication of electrospun (ES) hydrophilic PLA95/biocerimic membranes for GTR/GBR applications

Hsin Tai Hu, Hong Da Wu, Chang Chia-Hsiang, Sheng Yang Lee, Jen Chang Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The concept of guided tissue/bone regeneration (GTR/GBR) is using a barrier to maintain a space in order to prevent the migration of faster-growing soft tissue into the defect for ligament (PDL), cementum and bone reconstruction in dentistry. The aim of this study is to fabricate fibrous PLA95 (poly-5D/95L-lactide) /bioceramic membranes via electrospinning (ES) technique. Bio-ceramic such as calcium sulfate /phosphate (α-CaSO4/β- TCP) were chosen as fillers for co- electrospinning because of their osteoconductivity. The surface properties of hybrid ES membranes were modified to improve the hydrophobic properties by a dip-coating method. The physical and mechanical properties of ES membranes were explored. The morphology, structure, wettability, and suture strength of ES membranes were evaluated by SEM, XRD, contact angle and tensile tester, respectively. The resulted PLA95/bio-ceramic membranes show nice hydrophilic and good mechanical properties. The results of cytotoxicity test confirm those ES membranes would not induce any cell toxicity. Base on these results, we have successfully prepared composites of osteoconductive, hydrophilic and porous 3-D GTR/GBR membranes. The membrane system can be used as a prototype for the further development in many other clinical uses.

Original languageEnglish
Title of host publication7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010
PublisherACCM-7 Organizing Committee
Pages958-961
Number of pages4
Volume2
ISBN (Print)9781632660756
Publication statusPublished - 2010
Event7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010 - Taipei, Taiwan
Duration: Nov 15 2010Nov 18 2010

Other

Other7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010
CountryTaiwan
CityTaipei
Period11/15/1011/18/10

Keywords

  • Calcium sulfate/phosphate
  • Electrospinning
  • Guided tissue/bone regeneration (GTR/GBR)
  • Mechanical properties
  • Wettability

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials

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