Fabrication and characterization of Rhizochitosan and its incorporation with platelet concentrates to promote wound healing

Ling Chun Chen, Shyr Yi Lin, Ming Thau Sheu, Ching Hua Su, Hong Liang Lin, Chien Ming Hsieh

Research output: Contribution to journalArticlepeer-review

Abstract

Composite dressing composed of Rhizochitosan and Regenplex™ to promote wound healing were assessed. Rhizochitosan was fabricated by deacetylation of Rhizochitin, which obtained by simply depigmenting sporangium-free mycelial mattress produced from Rhizopus stolonifer F6. Physicochemical characterizations of Rhizochitosan demonstrated that it contained 13.5% chitosan with a water-absorption ability of 35-fold dry weight and exhibiting hydrogel nature after hydration. In a wound-healing study on SD rats with full-thickness injury, the composite dressing had a better healing effect than those for each individual components and control group and wound even healed as functional tissue instead of scar tissue. The underlying mechanism of the composite beneficial to wound remodeling is likely attributable to a more reduction level of matrix metalloproteinase (MMP)-9 expression in early stage and a higher MMP-2 expression level in a later stage of healing process. Conclusively, the composite dressing demonstrated to be highly beneficial to the healing of full-thickness injury wound.

Original languageEnglish
Article number118239
Pages (from-to)118239
JournalCarbohydrate Polymers
Volume268
DOIs
Publication statusPublished - Sep 15 2021

Keywords

  • Chitosan
  • Hydrogel
  • Rhizopus stolonifer
  • Wound healing

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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