Fabrication and characterization of a sponge-like asymmetric chitosan membrane as a wound dressing

Fwu Long Mi, Shin Shing Shyu, Yu B. Wu, Sung T. Lee, Jen Y. Shyong, Rong N. Huang

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534 Citations (Scopus)

Abstract

A novel asymmetric chitosan membrane has been prepared by immersion-precipitation phase-inversion method and evaluated as wound covering. This new type of chitosan wound dressing which consists of skin surface on top-layer supported by a macroporous sponge-like sublayer was designed. The thickness of the dense skin surface and porosity of sponge-like sublayer could be controlled by the modification of phase-separation process using per-evaporation method. The asymmetric chitosan membrane showed controlled evaporative water loss, excellent oxygen permeability and promoted fluid drainage ability but could inhibit exogenous microorganisms invasion due to the dense skin layer and inherent antimicrobial property of chitosan. Wound covered with the asymmetric chitosan membrane was hemostatic and healed quickly. Histological examination confirmed that epithelialization rate was increased and the deposition of collagen in the dermis was well organized by covering the wound with this asymmetric chitosan membrane. The results in this study indicate that the asymmetric chitosan membrane thus prepared could be adequately employed in the future as a wound dressing. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)165-173
Number of pages9
JournalBiomaterials
Volume22
Issue number2
DOIs
Publication statusPublished - Jan 15 2001
Externally publishedYes

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Keywords

  • Asymmetric membrane
  • Chitosan
  • Immersion-precipitation phase inversion
  • Wound dressing

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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