Extremely high prevalence and genetic diversity of hepatitis C virus infection among HIV-infected injection drug users in Taiwan

Jyh You Liu, Hsi Hsun Lin, Yung Ching Liu, Susan Shin Jung Lee, Ya Lei Chen, Chien Ching Hung, Wen Chien Ko, Chun Kai Huang, Chung Hsu Lai, Yao Shen Chen, Yi Li Shih, Hsing Chun Chung, Shiou Haur Liang, Jiun Nong Lin

Research output: Contribution to journalArticle

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Abstract

Background. An outbreak of human immunodeficiency virus (HIV) type 1 infection among injection drug users (IDUs) occurred in Taiwan, and thereafter, injection drug use became the most frequent risk factor for HIV infection in Taiwan. We sought to study the prevalence of and genotypes causing hepatitis C virus (HCV) infection among HIV-infected IDUs in Taiwan. Methods. A multicenter, longitudinal cohort study of 990 HIV-infected IDUs was conducted from 1993 through 2006. Blood samples were collected and analyzed for the presence of antibody to HCV and to determine the genotype of HCV. Results. The overall prevalence of HCV infection among HIV-infected IDUs was 96.6%. The annual prevalence increased from 65.5% before 2002 to 98.6% in 2006. The main circulating HCV genotypes were 1a (accounting for 29.2% of samples), 6a (23.5%), and 3a (20.2%), whereas 1b, the most predominant genotype circulating in the general population in Taiwan, accounted for only 13.2% of samples. Genotypes 2b (accounting for 6.6% of samples), 6k (2.9%), 2a (1.6%), 6g (1.6%), and 3b (1.2%) were present in only a few IDUs. Multivariate logistic regression analysis revealed that duration of injection drug use and a travel history to China or Southeast Asia were significantly associated with infection due to HCV genotypes 1a, 3, and 6. Conclusions. Our study demonstrated a high prevalence of HCV infection among HIV-infected IDUs in Taiwan, with a predominance of infection due to genotypes 1a, 6a, and 3a, as a result of the impact of IDUs' behavior and their drug trafficking route. Our study revealed that HCV infection in IDUs originated from a geographically large transmission network that was mainly distinct from that associated with other HCV-infected individuals; this transmission network has also been documented in association with HIV infection in IDUs.

Original languageEnglish
Pages (from-to)1761-1768
Number of pages8
JournalClinical Infectious Diseases
Volume46
Issue number11
DOIs
Publication statusPublished - Jun 1 2008
Externally publishedYes

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Virus Diseases
Drug Users
Taiwan
Hepacivirus
HIV
Injections
Genotype
Drug Trafficking
Southeastern Asia
Hepatitis C Antibodies
Infection
Pharmaceutical Preparations
Disease Outbreaks
Longitudinal Studies
HIV-1
China
Cohort Studies
Cross-Sectional Studies
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Immunology

Cite this

Extremely high prevalence and genetic diversity of hepatitis C virus infection among HIV-infected injection drug users in Taiwan. / Liu, Jyh You; Lin, Hsi Hsun; Liu, Yung Ching; Lee, Susan Shin Jung; Chen, Ya Lei; Hung, Chien Ching; Ko, Wen Chien; Huang, Chun Kai; Lai, Chung Hsu; Chen, Yao Shen; Shih, Yi Li; Chung, Hsing Chun; Liang, Shiou Haur; Lin, Jiun Nong.

In: Clinical Infectious Diseases, Vol. 46, No. 11, 01.06.2008, p. 1761-1768.

Research output: Contribution to journalArticle

Liu, JY, Lin, HH, Liu, YC, Lee, SSJ, Chen, YL, Hung, CC, Ko, WC, Huang, CK, Lai, CH, Chen, YS, Shih, YL, Chung, HC, Liang, SH & Lin, JN 2008, 'Extremely high prevalence and genetic diversity of hepatitis C virus infection among HIV-infected injection drug users in Taiwan', Clinical Infectious Diseases, vol. 46, no. 11, pp. 1761-1768. https://doi.org/10.1086/587992
Liu, Jyh You ; Lin, Hsi Hsun ; Liu, Yung Ching ; Lee, Susan Shin Jung ; Chen, Ya Lei ; Hung, Chien Ching ; Ko, Wen Chien ; Huang, Chun Kai ; Lai, Chung Hsu ; Chen, Yao Shen ; Shih, Yi Li ; Chung, Hsing Chun ; Liang, Shiou Haur ; Lin, Jiun Nong. / Extremely high prevalence and genetic diversity of hepatitis C virus infection among HIV-infected injection drug users in Taiwan. In: Clinical Infectious Diseases. 2008 ; Vol. 46, No. 11. pp. 1761-1768.
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abstract = "Background. An outbreak of human immunodeficiency virus (HIV) type 1 infection among injection drug users (IDUs) occurred in Taiwan, and thereafter, injection drug use became the most frequent risk factor for HIV infection in Taiwan. We sought to study the prevalence of and genotypes causing hepatitis C virus (HCV) infection among HIV-infected IDUs in Taiwan. Methods. A multicenter, longitudinal cohort study of 990 HIV-infected IDUs was conducted from 1993 through 2006. Blood samples were collected and analyzed for the presence of antibody to HCV and to determine the genotype of HCV. Results. The overall prevalence of HCV infection among HIV-infected IDUs was 96.6{\%}. The annual prevalence increased from 65.5{\%} before 2002 to 98.6{\%} in 2006. The main circulating HCV genotypes were 1a (accounting for 29.2{\%} of samples), 6a (23.5{\%}), and 3a (20.2{\%}), whereas 1b, the most predominant genotype circulating in the general population in Taiwan, accounted for only 13.2{\%} of samples. Genotypes 2b (accounting for 6.6{\%} of samples), 6k (2.9{\%}), 2a (1.6{\%}), 6g (1.6{\%}), and 3b (1.2{\%}) were present in only a few IDUs. Multivariate logistic regression analysis revealed that duration of injection drug use and a travel history to China or Southeast Asia were significantly associated with infection due to HCV genotypes 1a, 3, and 6. Conclusions. Our study demonstrated a high prevalence of HCV infection among HIV-infected IDUs in Taiwan, with a predominance of infection due to genotypes 1a, 6a, and 3a, as a result of the impact of IDUs' behavior and their drug trafficking route. Our study revealed that HCV infection in IDUs originated from a geographically large transmission network that was mainly distinct from that associated with other HCV-infected individuals; this transmission network has also been documented in association with HIV infection in IDUs.",
author = "Liu, {Jyh You} and Lin, {Hsi Hsun} and Liu, {Yung Ching} and Lee, {Susan Shin Jung} and Chen, {Ya Lei} and Hung, {Chien Ching} and Ko, {Wen Chien} and Huang, {Chun Kai} and Lai, {Chung Hsu} and Chen, {Yao Shen} and Shih, {Yi Li} and Chung, {Hsing Chun} and Liang, {Shiou Haur} and Lin, {Jiun Nong}",
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AU - Lin, Hsi Hsun

AU - Liu, Yung Ching

AU - Lee, Susan Shin Jung

AU - Chen, Ya Lei

AU - Hung, Chien Ching

AU - Ko, Wen Chien

AU - Huang, Chun Kai

AU - Lai, Chung Hsu

AU - Chen, Yao Shen

AU - Shih, Yi Li

AU - Chung, Hsing Chun

AU - Liang, Shiou Haur

AU - Lin, Jiun Nong

PY - 2008/6/1

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N2 - Background. An outbreak of human immunodeficiency virus (HIV) type 1 infection among injection drug users (IDUs) occurred in Taiwan, and thereafter, injection drug use became the most frequent risk factor for HIV infection in Taiwan. We sought to study the prevalence of and genotypes causing hepatitis C virus (HCV) infection among HIV-infected IDUs in Taiwan. Methods. A multicenter, longitudinal cohort study of 990 HIV-infected IDUs was conducted from 1993 through 2006. Blood samples were collected and analyzed for the presence of antibody to HCV and to determine the genotype of HCV. Results. The overall prevalence of HCV infection among HIV-infected IDUs was 96.6%. The annual prevalence increased from 65.5% before 2002 to 98.6% in 2006. The main circulating HCV genotypes were 1a (accounting for 29.2% of samples), 6a (23.5%), and 3a (20.2%), whereas 1b, the most predominant genotype circulating in the general population in Taiwan, accounted for only 13.2% of samples. Genotypes 2b (accounting for 6.6% of samples), 6k (2.9%), 2a (1.6%), 6g (1.6%), and 3b (1.2%) were present in only a few IDUs. Multivariate logistic regression analysis revealed that duration of injection drug use and a travel history to China or Southeast Asia were significantly associated with infection due to HCV genotypes 1a, 3, and 6. Conclusions. Our study demonstrated a high prevalence of HCV infection among HIV-infected IDUs in Taiwan, with a predominance of infection due to genotypes 1a, 6a, and 3a, as a result of the impact of IDUs' behavior and their drug trafficking route. Our study revealed that HCV infection in IDUs originated from a geographically large transmission network that was mainly distinct from that associated with other HCV-infected individuals; this transmission network has also been documented in association with HIV infection in IDUs.

AB - Background. An outbreak of human immunodeficiency virus (HIV) type 1 infection among injection drug users (IDUs) occurred in Taiwan, and thereafter, injection drug use became the most frequent risk factor for HIV infection in Taiwan. We sought to study the prevalence of and genotypes causing hepatitis C virus (HCV) infection among HIV-infected IDUs in Taiwan. Methods. A multicenter, longitudinal cohort study of 990 HIV-infected IDUs was conducted from 1993 through 2006. Blood samples were collected and analyzed for the presence of antibody to HCV and to determine the genotype of HCV. Results. The overall prevalence of HCV infection among HIV-infected IDUs was 96.6%. The annual prevalence increased from 65.5% before 2002 to 98.6% in 2006. The main circulating HCV genotypes were 1a (accounting for 29.2% of samples), 6a (23.5%), and 3a (20.2%), whereas 1b, the most predominant genotype circulating in the general population in Taiwan, accounted for only 13.2% of samples. Genotypes 2b (accounting for 6.6% of samples), 6k (2.9%), 2a (1.6%), 6g (1.6%), and 3b (1.2%) were present in only a few IDUs. Multivariate logistic regression analysis revealed that duration of injection drug use and a travel history to China or Southeast Asia were significantly associated with infection due to HCV genotypes 1a, 3, and 6. Conclusions. Our study demonstrated a high prevalence of HCV infection among HIV-infected IDUs in Taiwan, with a predominance of infection due to genotypes 1a, 6a, and 3a, as a result of the impact of IDUs' behavior and their drug trafficking route. Our study revealed that HCV infection in IDUs originated from a geographically large transmission network that was mainly distinct from that associated with other HCV-infected individuals; this transmission network has also been documented in association with HIV infection in IDUs.

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