Extreme Nocturnal Blood Pressure Dipping is Associated With Increased Arterial Stiffness in Individuals With Components of the Metabolic Syndrome

Lin Fang Chen, Ju-Chi Liu, Mei Yeh Wang, Shiow Li Hwang, Pei-Shan Tsai

Research output: Contribution to journalArticle

Abstract

Background and Purposes: The metabolic syndrome (MS) and abnormal nocturnal blood pressure (BP) dipping are both associated with increased risk of cardiovascular events. An association between MS and arterial stiffness was reported. This study aimed to examine the relationship between arterial stiffness as determined by the Cardio-Ankle Vascular Index (CAVI) and the nocturnal BP dipping pattern in normotensive individuals with one or more risk components of MS. Methods and Results: A total of 73 normotensive individuals who met at least one of the five National Cholesterol Education Program Adult Treatment Panel III criteria were included. The MS score was calculated according to the GISSI Study. Ambulatory BP was recorded every 30 minutes for a 48-hour period. Individuals with MS and those without MS did not significantly differ in CAVI (p=0.040) or nocturnal systolic blood pressure (SBP) dipping (p=0.909). Controlling for age, CAVI was not significantly correlated with the MS score (p=0.067). CAVI significantly correlated with the magnitude (ρ=0.29, p=0.014) and the percentage (ρ=0.29, p=0.013) of nocturnal SBP dipping. CAVI independently predicted the magnitude of nocturnal SBP reduction (β=0.364, p=0.002) even after adjusting for age and nighttime SBP. The extreme dippers had significantly higher CAVI values than the nondippers (p=0.012) and a trend toward higher CAVI than the dippers (p=0.031). Conclusion: MS is associated with neither arterial stiffness nor nocturnal dipping pattern in normotensives. However, in normotensive individuals with risk components of the MS, arterial stiffness is related to an extreme dipping pattern.

Original languageEnglish
Pages (from-to)132-136
Number of pages5
JournalJournal of Experimental and Clinical Medicine(Taiwan)
Volume3
Issue number3
DOIs
Publication statusPublished - Jun 2011

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Vascular Stiffness
Blood Pressure
Ankle
Blood Vessels
Cholesterol

Keywords

  • Arterial stiffness
  • Metabolic syndrome
  • Nocturnal systolic blood pressure dipping

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{ac5d24c2f58644acbf121d45623997a5,
title = "Extreme Nocturnal Blood Pressure Dipping is Associated With Increased Arterial Stiffness in Individuals With Components of the Metabolic Syndrome",
abstract = "Background and Purposes: The metabolic syndrome (MS) and abnormal nocturnal blood pressure (BP) dipping are both associated with increased risk of cardiovascular events. An association between MS and arterial stiffness was reported. This study aimed to examine the relationship between arterial stiffness as determined by the Cardio-Ankle Vascular Index (CAVI) and the nocturnal BP dipping pattern in normotensive individuals with one or more risk components of MS. Methods and Results: A total of 73 normotensive individuals who met at least one of the five National Cholesterol Education Program Adult Treatment Panel III criteria were included. The MS score was calculated according to the GISSI Study. Ambulatory BP was recorded every 30 minutes for a 48-hour period. Individuals with MS and those without MS did not significantly differ in CAVI (p=0.040) or nocturnal systolic blood pressure (SBP) dipping (p=0.909). Controlling for age, CAVI was not significantly correlated with the MS score (p=0.067). CAVI significantly correlated with the magnitude (ρ=0.29, p=0.014) and the percentage (ρ=0.29, p=0.013) of nocturnal SBP dipping. CAVI independently predicted the magnitude of nocturnal SBP reduction (β=0.364, p=0.002) even after adjusting for age and nighttime SBP. The extreme dippers had significantly higher CAVI values than the nondippers (p=0.012) and a trend toward higher CAVI than the dippers (p=0.031). Conclusion: MS is associated with neither arterial stiffness nor nocturnal dipping pattern in normotensives. However, in normotensive individuals with risk components of the MS, arterial stiffness is related to an extreme dipping pattern.",
keywords = "Arterial stiffness, Metabolic syndrome, Nocturnal systolic blood pressure dipping",
author = "Chen, {Lin Fang} and Ju-Chi Liu and Wang, {Mei Yeh} and Hwang, {Shiow Li} and Pei-Shan Tsai",
year = "2011",
month = "6",
doi = "10.1016/j.jecm.2011.04.007",
language = "English",
volume = "3",
pages = "132--136",
journal = "Journal of Experimental and Clinical Medicine",
issn = "1878-3317",
publisher = "Elsevier Taiwan LLC",
number = "3",

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TY - JOUR

T1 - Extreme Nocturnal Blood Pressure Dipping is Associated With Increased Arterial Stiffness in Individuals With Components of the Metabolic Syndrome

AU - Chen, Lin Fang

AU - Liu, Ju-Chi

AU - Wang, Mei Yeh

AU - Hwang, Shiow Li

AU - Tsai, Pei-Shan

PY - 2011/6

Y1 - 2011/6

N2 - Background and Purposes: The metabolic syndrome (MS) and abnormal nocturnal blood pressure (BP) dipping are both associated with increased risk of cardiovascular events. An association between MS and arterial stiffness was reported. This study aimed to examine the relationship between arterial stiffness as determined by the Cardio-Ankle Vascular Index (CAVI) and the nocturnal BP dipping pattern in normotensive individuals with one or more risk components of MS. Methods and Results: A total of 73 normotensive individuals who met at least one of the five National Cholesterol Education Program Adult Treatment Panel III criteria were included. The MS score was calculated according to the GISSI Study. Ambulatory BP was recorded every 30 minutes for a 48-hour period. Individuals with MS and those without MS did not significantly differ in CAVI (p=0.040) or nocturnal systolic blood pressure (SBP) dipping (p=0.909). Controlling for age, CAVI was not significantly correlated with the MS score (p=0.067). CAVI significantly correlated with the magnitude (ρ=0.29, p=0.014) and the percentage (ρ=0.29, p=0.013) of nocturnal SBP dipping. CAVI independently predicted the magnitude of nocturnal SBP reduction (β=0.364, p=0.002) even after adjusting for age and nighttime SBP. The extreme dippers had significantly higher CAVI values than the nondippers (p=0.012) and a trend toward higher CAVI than the dippers (p=0.031). Conclusion: MS is associated with neither arterial stiffness nor nocturnal dipping pattern in normotensives. However, in normotensive individuals with risk components of the MS, arterial stiffness is related to an extreme dipping pattern.

AB - Background and Purposes: The metabolic syndrome (MS) and abnormal nocturnal blood pressure (BP) dipping are both associated with increased risk of cardiovascular events. An association between MS and arterial stiffness was reported. This study aimed to examine the relationship between arterial stiffness as determined by the Cardio-Ankle Vascular Index (CAVI) and the nocturnal BP dipping pattern in normotensive individuals with one or more risk components of MS. Methods and Results: A total of 73 normotensive individuals who met at least one of the five National Cholesterol Education Program Adult Treatment Panel III criteria were included. The MS score was calculated according to the GISSI Study. Ambulatory BP was recorded every 30 minutes for a 48-hour period. Individuals with MS and those without MS did not significantly differ in CAVI (p=0.040) or nocturnal systolic blood pressure (SBP) dipping (p=0.909). Controlling for age, CAVI was not significantly correlated with the MS score (p=0.067). CAVI significantly correlated with the magnitude (ρ=0.29, p=0.014) and the percentage (ρ=0.29, p=0.013) of nocturnal SBP dipping. CAVI independently predicted the magnitude of nocturnal SBP reduction (β=0.364, p=0.002) even after adjusting for age and nighttime SBP. The extreme dippers had significantly higher CAVI values than the nondippers (p=0.012) and a trend toward higher CAVI than the dippers (p=0.031). Conclusion: MS is associated with neither arterial stiffness nor nocturnal dipping pattern in normotensives. However, in normotensive individuals with risk components of the MS, arterial stiffness is related to an extreme dipping pattern.

KW - Arterial stiffness

KW - Metabolic syndrome

KW - Nocturnal systolic blood pressure dipping

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