Extrapulmonary tuberculosis in chronic hemodialysis patients

Feng Rong Chuang, Chih Hsiung Lee, I. Kuan Wang, Jin Bor Chen, Mai Szu Wu

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background. The incidence of extrapulmonary tuberculosis is higher in dialysis than general population. The aim of the study was to characterize clinical picture in dialysis patients, who developed extrapulmonary tuberculosis. Methods. We retrospectively investigated the hemodialysis patients with extrapulmonary tuberculosis. 2208 hemodialysis patients were reviewed for extrapulmonary tuberculosis from October 1986 to January 2001. Results. Seventeen patients (10 male, 7 female) were enrolled. The mean age was 57.4 ± 12.4 years. The sites for extrapulmonary tuberculosis were peritoneum (35.3%, 6/17), cervical lymph node (17.6%, 3/17), bone marrow (5.9%, 1/17), spine (5.9%, 1/17), knee (5.9%, 1/17), brain (5.9%, 1/17), pericardium (5.9%, 1/17), cutaneous tissue (5.9%, 1/17) and genitourinary system (5.9%, 1/17). Fourteen of 15 tissue-biopsy specimens from suspicious sites revealed granulomatous inflammation. There were low yield in mycobacteria culture (11.1%, 1/9) and PCR (33.3%, 2/6). Three patients died during the treatment of the disease. Conclusion. Extrapulmonary tuberculosis constitutes a major part of tuberculosis in dialysis patients. Tissue biopsy with invasive procedures, such as laparoscopy or laparotomy, may be necessary if clinical presentations are suspicious.

Original languageEnglish
Pages (from-to)739-746
Number of pages8
JournalRenal Failure
Volume25
Issue number5
DOIs
Publication statusPublished - 2003
Externally publishedYes

Keywords

  • Extrapulmonary tuberculosis
  • Hemodialysis
  • Laparoscopy
  • Laparotomy

ASJC Scopus subject areas

  • Nephrology

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