Extrapulmonary small cell carcinoma

A review

Chang Hsien Lu, Wen Chi Chou, Chih Chen Chen, Jen Tsun Lin, Chung Huang Chan, Kuan Der Lee

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Extrapulmonary small cell carcinoma (EPSCC) is a relatively rare malignancy accounting for only 2.5-4% of all small cell carcinomas. The head and neck, gastrointestinal tract, genitourinary and gynecologic organs are most common tumor sites. EPSCC behaves aggressively like the small cell lung cancer (SCLC) and its prognosis is dismal. Its tumorigenesis and molecular alternations remain poorly understood. The clinical diagnosis, staging and treatment of EPSCC are challenging. The extent of disease is important for prognosis whereas the tumor location affects the choice of treatment modality. Currently there is no standard guideline as yet. Combined modality (surgery, radiation or chemotherapy) treatment has often been applied to limited-stage EPSCCs in which long-term survivors have ever been reported. However, the sequence of these combinations is not well-defined. Palliative chemotherapy is used for extensive and recurrent/ metastatic EPSCCs with high response rate but short progression-free interval. More research is warranted for improving the survival.

Original languageEnglish
Pages (from-to)294-300
Number of pages7
JournalJournal of Internal Medicine of Taiwan
Volume20
Issue number4
Publication statusPublished - Aug 2009
Externally publishedYes

Fingerprint

Small Cell Carcinoma
Drug Therapy
Neoplasms
Small Cell Lung Carcinoma
Survivors
Gastrointestinal Tract
Carcinogenesis
Neck
Therapeutics
Head
Guidelines
Radiation
Survival
Research

Keywords

  • Extrapulmonary small cell carcinoma (EPSCC)
  • Small cell lung cancer (SCLC)

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Lu, C. H., Chou, W. C., Chen, C. C., Lin, J. T., Chan, C. H., & Lee, K. D. (2009). Extrapulmonary small cell carcinoma: A review. Journal of Internal Medicine of Taiwan, 20(4), 294-300.

Extrapulmonary small cell carcinoma : A review. / Lu, Chang Hsien; Chou, Wen Chi; Chen, Chih Chen; Lin, Jen Tsun; Chan, Chung Huang; Lee, Kuan Der.

In: Journal of Internal Medicine of Taiwan, Vol. 20, No. 4, 08.2009, p. 294-300.

Research output: Contribution to journalReview article

Lu, CH, Chou, WC, Chen, CC, Lin, JT, Chan, CH & Lee, KD 2009, 'Extrapulmonary small cell carcinoma: A review', Journal of Internal Medicine of Taiwan, vol. 20, no. 4, pp. 294-300.
Lu CH, Chou WC, Chen CC, Lin JT, Chan CH, Lee KD. Extrapulmonary small cell carcinoma: A review. Journal of Internal Medicine of Taiwan. 2009 Aug;20(4):294-300.
Lu, Chang Hsien ; Chou, Wen Chi ; Chen, Chih Chen ; Lin, Jen Tsun ; Chan, Chung Huang ; Lee, Kuan Der. / Extrapulmonary small cell carcinoma : A review. In: Journal of Internal Medicine of Taiwan. 2009 ; Vol. 20, No. 4. pp. 294-300.
@article{212889e757b44ba29f63abe92200a918,
title = "Extrapulmonary small cell carcinoma: A review",
abstract = "Extrapulmonary small cell carcinoma (EPSCC) is a relatively rare malignancy accounting for only 2.5-4{\%} of all small cell carcinomas. The head and neck, gastrointestinal tract, genitourinary and gynecologic organs are most common tumor sites. EPSCC behaves aggressively like the small cell lung cancer (SCLC) and its prognosis is dismal. Its tumorigenesis and molecular alternations remain poorly understood. The clinical diagnosis, staging and treatment of EPSCC are challenging. The extent of disease is important for prognosis whereas the tumor location affects the choice of treatment modality. Currently there is no standard guideline as yet. Combined modality (surgery, radiation or chemotherapy) treatment has often been applied to limited-stage EPSCCs in which long-term survivors have ever been reported. However, the sequence of these combinations is not well-defined. Palliative chemotherapy is used for extensive and recurrent/ metastatic EPSCCs with high response rate but short progression-free interval. More research is warranted for improving the survival.",
keywords = "Extrapulmonary small cell carcinoma (EPSCC), Small cell lung cancer (SCLC)",
author = "Lu, {Chang Hsien} and Chou, {Wen Chi} and Chen, {Chih Chen} and Lin, {Jen Tsun} and Chan, {Chung Huang} and Lee, {Kuan Der}",
year = "2009",
month = "8",
language = "English",
volume = "20",
pages = "294--300",
journal = "Journal of Internal Medicine of Taiwan",
issn = "1016-7390",
publisher = "臺灣內科醫學會",
number = "4",

}

TY - JOUR

T1 - Extrapulmonary small cell carcinoma

T2 - A review

AU - Lu, Chang Hsien

AU - Chou, Wen Chi

AU - Chen, Chih Chen

AU - Lin, Jen Tsun

AU - Chan, Chung Huang

AU - Lee, Kuan Der

PY - 2009/8

Y1 - 2009/8

N2 - Extrapulmonary small cell carcinoma (EPSCC) is a relatively rare malignancy accounting for only 2.5-4% of all small cell carcinomas. The head and neck, gastrointestinal tract, genitourinary and gynecologic organs are most common tumor sites. EPSCC behaves aggressively like the small cell lung cancer (SCLC) and its prognosis is dismal. Its tumorigenesis and molecular alternations remain poorly understood. The clinical diagnosis, staging and treatment of EPSCC are challenging. The extent of disease is important for prognosis whereas the tumor location affects the choice of treatment modality. Currently there is no standard guideline as yet. Combined modality (surgery, radiation or chemotherapy) treatment has often been applied to limited-stage EPSCCs in which long-term survivors have ever been reported. However, the sequence of these combinations is not well-defined. Palliative chemotherapy is used for extensive and recurrent/ metastatic EPSCCs with high response rate but short progression-free interval. More research is warranted for improving the survival.

AB - Extrapulmonary small cell carcinoma (EPSCC) is a relatively rare malignancy accounting for only 2.5-4% of all small cell carcinomas. The head and neck, gastrointestinal tract, genitourinary and gynecologic organs are most common tumor sites. EPSCC behaves aggressively like the small cell lung cancer (SCLC) and its prognosis is dismal. Its tumorigenesis and molecular alternations remain poorly understood. The clinical diagnosis, staging and treatment of EPSCC are challenging. The extent of disease is important for prognosis whereas the tumor location affects the choice of treatment modality. Currently there is no standard guideline as yet. Combined modality (surgery, radiation or chemotherapy) treatment has often been applied to limited-stage EPSCCs in which long-term survivors have ever been reported. However, the sequence of these combinations is not well-defined. Palliative chemotherapy is used for extensive and recurrent/ metastatic EPSCCs with high response rate but short progression-free interval. More research is warranted for improving the survival.

KW - Extrapulmonary small cell carcinoma (EPSCC)

KW - Small cell lung cancer (SCLC)

UR - http://www.scopus.com/inward/record.url?scp=70349194499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349194499&partnerID=8YFLogxK

M3 - Review article

VL - 20

SP - 294

EP - 300

JO - Journal of Internal Medicine of Taiwan

JF - Journal of Internal Medicine of Taiwan

SN - 1016-7390

IS - 4

ER -