Extraordinary muscular structure leads to urethral injury after vaginal delivery in animal study

Hung Yen Chin, Eileen Changchien, Chi Hsin Chiang, Hsiu Ping Yang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction and hypothesis: The aim of this study is to explore causality of birth trauma after vaginal delivery and anatomical findings. Methods: A total of 28 virgin mice were studied. Treatment groups received vaginal distention. Specimens were collected and subjected to the following fluorescence stains: progenitor cell (c-kit), smooth muscle (SMA), fibroblast (vimentin), and skeleton muscle (Masson's trichrome). Confocal microscopy was used to screen all of the urogenital tissue to localize the stained cells. Results: Fibroblasts were spread all over perivaginal and urethral surroundings. Progenitor cells appeared at urethral-vagina intersection and urethral circle. They were noticeable only within smooth muscle layer. Two extraordinary skeleton muscle bands appeared on the urethra bilaterally. Conclusions: Our study demonstrates existence of muscle bands at the bilateral urethra. They can limit the mobility of urethra during vaginal delivery and thereby cause urethra injury. Progenitor cells are located only in the smooth muscle of the urethral circle.

Original languageEnglish
Pages (from-to)1231-1236
Number of pages6
JournalInternational Urogynecology Journal
Volume21
Issue number10
DOIs
Publication statusPublished - Jan 1 2010
Externally publishedYes

Fingerprint

Urethra
Smooth Muscle
Stem Cells
Wounds and Injuries
Skeleton
Muscles
Fibroblasts
Vagina
Vimentin
Confocal Microscopy
Causality
Coloring Agents
Fluorescence
Parturition

Keywords

  • Birth trauma
  • Fibrosis
  • Stem cells
  • Urethral injury
  • Urinary incontinence
  • Urogenital structure

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Urology

Cite this

Extraordinary muscular structure leads to urethral injury after vaginal delivery in animal study. / Chin, Hung Yen; Changchien, Eileen; Chiang, Chi Hsin; Yang, Hsiu Ping.

In: International Urogynecology Journal, Vol. 21, No. 10, 01.01.2010, p. 1231-1236.

Research output: Contribution to journalArticle

Chin, Hung Yen ; Changchien, Eileen ; Chiang, Chi Hsin ; Yang, Hsiu Ping. / Extraordinary muscular structure leads to urethral injury after vaginal delivery in animal study. In: International Urogynecology Journal. 2010 ; Vol. 21, No. 10. pp. 1231-1236.
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