Extended use of intravenous bisphosphonate therapy for the prevention of skeletal complications in patients with cancer

Xi Wang, Jing Ni, Chen Long Hsu, Sharlin Johnykutty, Ping Tang, Yuan Soon Ho, Chia Hwa Lee, Shuyuang Yeh

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We show that TAP/Sec14L2 had a high expression in normal/benign breast, prostate, and liver tissues as compared to lung, colon, and kidney. Its expression was downregulated in breast cancer cell lines shown by quantitative-PCR. Further, 57% of 141 human invasive breast carcinomas had no or markedly reduced TAP/Sec14L2 expression by immunohistochemical staining, and the rate increased to 80% in high grade invasive carcinomas ( p <.01). This downregulation of TAP/Sec14L2 was also present in ductal carcinoma in situ(DCIS) associated with invasive carcinomas. These findings raise the possibility that TAP/Sec14L2 may serve as a tumor suppressor in breast carcinogenesis.

Original languageEnglish
Pages (from-to)971-977
Number of pages7
JournalCancer Investigation
Volume27
Issue number10
DOIs
Publication statusPublished - Nov 13 2009

Fingerprint

Diphosphonates
Breast
Down-Regulation
Breast Neoplasms
Carcinoma
Carcinoma, Intraductal, Noninfiltrating
Prostate
Neoplasms
Colon
Carcinogenesis
Staining and Labeling
Kidney
Cell Line
Polymerase Chain Reaction
Lung
Liver
Therapeutics

Keywords

  • BCa
  • TAP

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Extended use of intravenous bisphosphonate therapy for the prevention of skeletal complications in patients with cancer. / Wang, Xi; Ni, Jing; Hsu, Chen Long; Johnykutty, Sharlin; Tang, Ping; Ho, Yuan Soon; Lee, Chia Hwa; Yeh, Shuyuang.

In: Cancer Investigation, Vol. 27, No. 10, 13.11.2009, p. 971-977.

Research output: Contribution to journalArticle

Wang, Xi ; Ni, Jing ; Hsu, Chen Long ; Johnykutty, Sharlin ; Tang, Ping ; Ho, Yuan Soon ; Lee, Chia Hwa ; Yeh, Shuyuang. / Extended use of intravenous bisphosphonate therapy for the prevention of skeletal complications in patients with cancer. In: Cancer Investigation. 2009 ; Vol. 27, No. 10. pp. 971-977.
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