Expression of the interleukin-2 receptor α (CD25) is selectively decreased on decidual CD4 + and CD8 + T lymphocytes in normal pregnancies

Kunag Han Chao, Ming Yih Wu, Jehn Hsiahn Yang, Shee Uan Chen, Yu Shih Yang, Hong Nerng Ho

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

In a previous study, we demonstrated that the proportion of activated T cells (CD69 +CD3 + and HLA-DR +CD3 +) is higher in the endometrium and decidua after the luteal phase and throughout early pregnancy compared with in the peripheral blood. However, there was no difference in the proportion of CD25 +CD3 + lymphocytes between the endometrium and peripheral blood. In this study, we further verify that the levels of CD25 on CD4 + and CD8 + T lymphocytes are not increased in normal pregnancy, although the levels of CD69 and HLA-DR are markedly increased. We also elucidate that the amounts of all three activation molecules on local T lymphocytes are down-regulated in pregnancy compared with that during the luteal phase. Nevertheless, these decreases are significantly lessened in anembryonic pregnancies with both normal and abnormal karyotyping. However, in peripheral blood, the down-regulation of activation molecules levels in pregnancy is only demonstrated on CD4 + cells and for HLA-DR on CD8 + cells. Furthermore, dual activation marker analysis demonstrated that the expression of CD25 appears to be dissociated from CD69 and HLA-DR on the same decidual lymphocytes. Because IL-2Rα plays a pivotal role in the development and propagation of functional T cells, its depressed expression may result in maternal tolerance of the fetal allograft.

Original languageEnglish
Pages (from-to)667-673
Number of pages7
JournalMolecular Human Reproduction
Volume8
Issue number7
Publication statusPublished - Jul 22 2002
Externally publishedYes

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Interleukin-2 Receptors
HLA-DR Antigens
T-Lymphocytes
Pregnancy
Luteal Phase
Endometrium
Lymphocytes
Activation Analysis
Transplantation Tolerance
Decidua
Karyotyping
Down-Regulation
Mothers

Keywords

  • CD25
  • CD69
  • Decidua
  • HLA-DR
  • T lymphocytes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Embryology
  • Molecular Biology
  • Genetics
  • Obstetrics and Gynaecology
  • Developmental Biology
  • Cell Biology

Cite this

Expression of the interleukin-2 receptor α (CD25) is selectively decreased on decidual CD4 + and CD8 + T lymphocytes in normal pregnancies. / Chao, Kunag Han; Wu, Ming Yih; Yang, Jehn Hsiahn; Chen, Shee Uan; Yang, Yu Shih; Ho, Hong Nerng.

In: Molecular Human Reproduction, Vol. 8, No. 7, 22.07.2002, p. 667-673.

Research output: Contribution to journalArticle

Chao, Kunag Han ; Wu, Ming Yih ; Yang, Jehn Hsiahn ; Chen, Shee Uan ; Yang, Yu Shih ; Ho, Hong Nerng. / Expression of the interleukin-2 receptor α (CD25) is selectively decreased on decidual CD4 + and CD8 + T lymphocytes in normal pregnancies. In: Molecular Human Reproduction. 2002 ; Vol. 8, No. 7. pp. 667-673.
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