Expression of nm23 in the primary tumor and the metastatic regional lymph nodes of patients with gastric cardiac cancer

Nan Yung Hsu, Kuan Chih Chow, Wei J. Chen, Cheng Ching Lin, Fong F. Chou, Chao Long Chen

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32 Citations (Scopus)

Abstract

Tumor recurrence and distant metastasis are major causes of treatment failure in gastric cardiac cancer (GCC). Rapid growth of tumor cells and reduced expression of nm23, a metastatic suppressor gene, in tumor cells have been suggested as two important mechanisms for disease progression of GCC. Therefore, to determine the prognostic value of nm23 expression in GCC, we used immunohistochemistry to examine the expression of nm23 in the pathological sections of both gastric cancer and metastatic lymph nodes from 24 stage III patients. Twenty-two patients had total gastrectomy, and two patients had proximal subtotal gastrectomy with a D2 dissection. Postoperative adjuvant therapy was provided, and the clinical responses were followed routinely. Clinical correlation was evaluated by χ2 with Fisher's exact test and survival by log-rank test. Our results show that the reduced nm23 expression in the primary tumor and in the nodal metastasis is the most useful marker for the poor prognosis of GCC following surgery.

Original languageEnglish
Pages (from-to)1752-1757
Number of pages6
JournalClinical Cancer Research
Volume5
Issue number7
Publication statusPublished - Jul 1999
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Hsu, N. Y., Chow, K. C., Chen, W. J., Lin, C. C., Chou, F. F., & Chen, C. L. (1999). Expression of nm23 in the primary tumor and the metastatic regional lymph nodes of patients with gastric cardiac cancer. Clinical Cancer Research, 5(7), 1752-1757.