Expression of Matrix Metalloproteinases in Oral Cancer Patients Who Are Betel Quid Users

邱 昶達(C. T. Chiu), 莊 晴雅(C. Y. Chuang), 張 松文(S. W. Chang), 李 勝揚(S. Y. Lee), 王 敦正(D. J. Wang), 劉 永超(Y. C. Liu), 劉 巡宇(S. Y. Liu), 顏 欽堉(C. Y. Yen), 蔣 維凡(W. F. Chang)

Research output: Contribution to journalArticle

Abstract

The rate of squamous cell carcinoma (SCC) is the highest among oral cancers, and most of these patients have chewed betel nuts for a long time. Betel nut chewing has been proven to cause oral cancer. During tumor invasion and proliferation, matrix metalloproteinases (MMPs) family are some of the most important factors. MMPs can remodel peripheral tissues of tumors, and their expression can be induced during interactions among tumor cells, the extracellular matrix (ECM), and inflammatory cells. Thus the up- and downregulated expressions of MMPs significantly differ when applied to predicting tumor cell invasion and transfer. The overexpression of some MMPs was associated with oral cancer occurrence, proliferation, lymph node metastasis, and prognosis in recent studies. The Department of Oral and Maxillofacial Surgery of Chi-Mei Medical Center (Tainan, Taiwan) has particularly studied MMP expressions in patient, associated with betel nut chewing. Significant increases in MMP-1, -2, -3, -8, -9, and -28 expression in oral cancer patients with betel nut chewing habit have recently been found in our studies and reported in other papers. Betel nut extract (ANE) and arecoline are known to trigger MMP expression signals based on MEK/ERK and P1-3K signal transduction expression intensities and MMP production increments. This paper collected and analysed our data of MMPs studies. Our findings show the correspondence with other researchers’ reports. We think that these MMPs can be considered to be used as oral cancer cell markers and can be used to predict cancer prognosis.
Original languageEnglish
Pages (from-to)313-327
Number of pages15
Journal臺灣口腔顎面外科學會雜誌
Volume19
Issue number4
Publication statusPublished - 2008

Fingerprint

Mouth Neoplasms
Matrix Metalloproteinases
Areca
Mastication
Oral Surgery
Neoplasms
Arecoline
Matrix Metalloproteinase 1
Matrix Metalloproteinase 2
Mitogen-Activated Protein Kinase Kinases
Taiwan
Habits
Extracellular Matrix
Squamous Cell Carcinoma
Signal Transduction
Down-Regulation
Lymph Nodes
Research Personnel
Neoplasm Metastasis

Keywords

  • Squamous cell carcinoma
  • Betel nut
  • Metalloproteinases

Cite this

邱昶達(C T C, 莊晴雅(C Y C, 張松文(S W C, 李勝揚(S Y L, 王敦正(D J W, 劉永超(Y C L, ... 蔣維凡(W F C (2008). Expression of Matrix Metalloproteinases in Oral Cancer Patients Who Are Betel Quid Users. 臺灣口腔顎面外科學會雜誌, 19(4), 313-327.

Expression of Matrix Metalloproteinases in Oral Cancer Patients Who Are Betel Quid Users. / 邱昶達(C. T. Chiu); 莊晴雅(C. Y. Chuang); 張松文(S. W. Chang); 李勝揚(S. Y. Lee); 王敦正(D. J. Wang); 劉永超(Y. C. Liu); 劉巡宇(S. Y. Liu); 顏欽堉(C. Y. Yen); 蔣維凡(W. F. Chang).

In: 臺灣口腔顎面外科學會雜誌, Vol. 19, No. 4, 2008, p. 313-327.

Research output: Contribution to journalArticle

邱昶達(CTC, 莊晴雅(CYC, 張松文(SWC, 李勝揚(SYL, 王敦正(DJW, 劉永超(YCL, 劉巡宇(SYL, 顏欽堉(CYY & 蔣維凡(WFC 2008, 'Expression of Matrix Metalloproteinases in Oral Cancer Patients Who Are Betel Quid Users', 臺灣口腔顎面外科學會雜誌, vol. 19, no. 4, pp. 313-327.
邱昶達(CTC, 莊晴雅(CYC, 張松文(SWC, 李勝揚(SYL, 王敦正(DJW, 劉永超(YCL et al. Expression of Matrix Metalloproteinases in Oral Cancer Patients Who Are Betel Quid Users. 臺灣口腔顎面外科學會雜誌. 2008;19(4):313-327.
邱昶達(C. T. Chiu) ; 莊晴雅(C. Y. Chuang) ; 張松文(S. W. Chang) ; 李勝揚(S. Y. Lee) ; 王敦正(D. J. Wang) ; 劉永超(Y. C. Liu) ; 劉巡宇(S. Y. Liu) ; 顏欽堉(C. Y. Yen) ; 蔣維凡(W. F. Chang). / Expression of Matrix Metalloproteinases in Oral Cancer Patients Who Are Betel Quid Users. In: 臺灣口腔顎面外科學會雜誌. 2008 ; Vol. 19, No. 4. pp. 313-327.
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abstract = "The rate of squamous cell carcinoma (SCC) is the highest among oral cancers, and most of these patients have chewed betel nuts for a long time. Betel nut chewing has been proven to cause oral cancer. During tumor invasion and proliferation, matrix metalloproteinases (MMPs) family are some of the most important factors. MMPs can remodel peripheral tissues of tumors, and their expression can be induced during interactions among tumor cells, the extracellular matrix (ECM), and inflammatory cells. Thus the up- and downregulated expressions of MMPs significantly differ when applied to predicting tumor cell invasion and transfer. The overexpression of some MMPs was associated with oral cancer occurrence, proliferation, lymph node metastasis, and prognosis in recent studies. The Department of Oral and Maxillofacial Surgery of Chi-Mei Medical Center (Tainan, Taiwan) has particularly studied MMP expressions in patient, associated with betel nut chewing. Significant increases in MMP-1, -2, -3, -8, -9, and -28 expression in oral cancer patients with betel nut chewing habit have recently been found in our studies and reported in other papers. Betel nut extract (ANE) and arecoline are known to trigger MMP expression signals based on MEK/ERK and P1-3K signal transduction expression intensities and MMP production increments. This paper collected and analysed our data of MMPs studies. Our findings show the correspondence with other researchers’ reports. We think that these MMPs can be considered to be used as oral cancer cell markers and can be used to predict cancer prognosis.",
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AU - 張, 松文(S. W. Chang)

AU - 李, 勝揚(S. Y. Lee)

AU - 王, 敦正(D. J. Wang)

AU - 劉, 永超(Y. C. Liu)

AU - 劉, 巡宇(S. Y. Liu)

AU - 顏, 欽堉(C. Y. Yen)

AU - 蔣, 維凡(W. F. Chang)

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N2 - The rate of squamous cell carcinoma (SCC) is the highest among oral cancers, and most of these patients have chewed betel nuts for a long time. Betel nut chewing has been proven to cause oral cancer. During tumor invasion and proliferation, matrix metalloproteinases (MMPs) family are some of the most important factors. MMPs can remodel peripheral tissues of tumors, and their expression can be induced during interactions among tumor cells, the extracellular matrix (ECM), and inflammatory cells. Thus the up- and downregulated expressions of MMPs significantly differ when applied to predicting tumor cell invasion and transfer. The overexpression of some MMPs was associated with oral cancer occurrence, proliferation, lymph node metastasis, and prognosis in recent studies. The Department of Oral and Maxillofacial Surgery of Chi-Mei Medical Center (Tainan, Taiwan) has particularly studied MMP expressions in patient, associated with betel nut chewing. Significant increases in MMP-1, -2, -3, -8, -9, and -28 expression in oral cancer patients with betel nut chewing habit have recently been found in our studies and reported in other papers. Betel nut extract (ANE) and arecoline are known to trigger MMP expression signals based on MEK/ERK and P1-3K signal transduction expression intensities and MMP production increments. This paper collected and analysed our data of MMPs studies. Our findings show the correspondence with other researchers’ reports. We think that these MMPs can be considered to be used as oral cancer cell markers and can be used to predict cancer prognosis.

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