Expression of hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF)-D as outcome predictors in resected esophageal squamous cell carcinoma

Ching Tzao, Shih Chun Lee, Ho J. Tung, Han Shui Hsu, Wen H. Hsu, Guang Huan Sun, Cheng Ping Yu, Jong Shiaw Jin, Yeung Leung Cheng

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) are important angiogenic factors in human cancers. Relative to VEGF-C, prognostic significance of VEGF-D expression and its association with HIF-1α expression remain elusive in esophageal squamous cell cancer (ESCC). We studied expression of HIF-1α and VEGF-D using immunohistochemistry in 85 resected ESCC specimens and correlated results with patients' clinicopathologic parameters and survival. Association between expression of HIF-1α and VEGF-D was investigated using a concordance analysis. High expression of HIF-1α and VEGF-D was observed in 52 (61.2%) and 56 (65.9%) patients, respectively. HIF-1α expression correlated well with tumor stage (P = 0.041), whereas VEGF-D expression correlated with tumor stage (P = 0.027) and N status (P = 0.019). Groups of high HIF-1α and VEGF-D showed worse survivals than those of low expression (P = 0.002 and 0.001, respectively). Multivariate analysis supported expression of HIF-1α and VEGF-D as significant survival predictors (P = 0.044 and 0.035, respectively). A concordance rate of 69.5% was observed between expression of HIF-1α and VEGF-D. In conclusion, protein expression of HIF-1α and VEGF-D are independent prognostic predictors. An association between expression of HIF-1α and VEGF-D suggests that these two angiogenic factors are essential in progression of ESCC.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalDisease Markers
Volume25
Issue number3
Publication statusPublished - 2008
Externally publishedYes

    Fingerprint

Keywords

  • Esophageal squamous cell carcinoma
  • Hypoxia-inducible factor (HIF)-1α
  • Prognosis
  • Survival
  • Vascular endothelial growth factor (VEGF)-D

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Genetics
  • Molecular Biology
  • Biochemistry, medical

Cite this

Tzao, C., Lee, S. C., Tung, H. J., Hsu, H. S., Hsu, W. H., Sun, G. H., Yu, C. P., Jin, J. S., & Cheng, Y. L. (2008). Expression of hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF)-D as outcome predictors in resected esophageal squamous cell carcinoma. Disease Markers, 25(3), 141-148.