Expression of Epstein-Barr virus latent membrane protein 1 and B-cell leukemia-lymphoma 2 gene in nasopharyngeal carcinoma tissues

John Jenn Yenn Lu, Chi Long Chen, Tsuey Ying Hsu, Jen Yang Chen, Ih Jen Su, Winston C Y Yu, Czau Siung Yang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Co-expression of B-cell leukemia-lymphoma 2 gene (Bcl-2) and Epstein-Barr virus latent membrane protein 1 (LMP-1) in nasopharyngeal carcinoma tissues were tested using immunohistochemical methods. Results showed that there were 32% (14/44) and 68% (30/44) LMP-1 and Bcl-2-positive cases, respectively. Among the LMP-1-positive tissues, 8 (57%) of 14 specimens were also Bcl-2-positive. The level of LMP-1 and Bcl-2 expression was associated with the clinical stages of nasopharyngeal carcinoma. Furthermore, when LMP-1- and Bcl-2-positive cases were combined, the highest positive score was found in clinical stage II as well as in the early stage (stages I and II) of nasopharyngeal carcinoma. While further studies with more cases are needed, this study suggests that co-expression of Bcl-2 and LMP-1 may be involved in the process of nasopharyngeal carcinoma aggravation.

Original languageEnglish
Pages (from-to)136-140
Number of pages5
JournalJournal of Microbiology, Immunology and Infection
Volume35
Issue number2
Publication statusPublished - 2002
Externally publishedYes

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B-Cell Leukemia
B-Cell Lymphoma
Membrane Proteins
Genes
IgA receptor
Nasopharyngeal carcinoma
Epstein-Barr virus EBV-associated membrane antigen
Gene Expression

Keywords

  • B-cell leukemia-lymphoma 2 gene (Bcl-2)
  • Epstein-Barr virus
  • Latent membrane protein 1 (LMP-1)
  • Nasopharyngeal carcinoma

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Immunology and Allergy
  • Microbiology (medical)

Cite this

Expression of Epstein-Barr virus latent membrane protein 1 and B-cell leukemia-lymphoma 2 gene in nasopharyngeal carcinoma tissues. / Lu, John Jenn Yenn; Chen, Chi Long; Hsu, Tsuey Ying; Chen, Jen Yang; Su, Ih Jen; Yu, Winston C Y; Yang, Czau Siung.

In: Journal of Microbiology, Immunology and Infection, Vol. 35, No. 2, 2002, p. 136-140.

Research output: Contribution to journalArticle

Lu, John Jenn Yenn ; Chen, Chi Long ; Hsu, Tsuey Ying ; Chen, Jen Yang ; Su, Ih Jen ; Yu, Winston C Y ; Yang, Czau Siung. / Expression of Epstein-Barr virus latent membrane protein 1 and B-cell leukemia-lymphoma 2 gene in nasopharyngeal carcinoma tissues. In: Journal of Microbiology, Immunology and Infection. 2002 ; Vol. 35, No. 2. pp. 136-140.
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