Expression of Epstein-Barr virus latent membrane protein 1 and B-cell leukemia-lymphoma 2 gene in nasopharyngeal carcinoma tissues

John Jenn Yenn Lu, Chi Long Chen, Tsuey Ying Hsu, Jen Yang Chen, Ih Jen Su, Winston C Y Yu, Czau Siung Yang

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9 Citations (Scopus)


Co-expression of B-cell leukemia-lymphoma 2 gene (Bcl-2) and Epstein-Barr virus latent membrane protein 1 (LMP-1) in nasopharyngeal carcinoma tissues were tested using immunohistochemical methods. Results showed that there were 32% (14/44) and 68% (30/44) LMP-1 and Bcl-2-positive cases, respectively. Among the LMP-1-positive tissues, 8 (57%) of 14 specimens were also Bcl-2-positive. The level of LMP-1 and Bcl-2 expression was associated with the clinical stages of nasopharyngeal carcinoma. Furthermore, when LMP-1- and Bcl-2-positive cases were combined, the highest positive score was found in clinical stage II as well as in the early stage (stages I and II) of nasopharyngeal carcinoma. While further studies with more cases are needed, this study suggests that co-expression of Bcl-2 and LMP-1 may be involved in the process of nasopharyngeal carcinoma aggravation.

Original languageEnglish
Pages (from-to)136-140
Number of pages5
JournalJournal of Microbiology, Immunology and Infection
Issue number2
Publication statusPublished - 2002
Externally publishedYes



  • B-cell leukemia-lymphoma 2 gene (Bcl-2)
  • Epstein-Barr virus
  • Latent membrane protein 1 (LMP-1)
  • Nasopharyngeal carcinoma

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Immunology and Allergy
  • Microbiology (medical)

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