Expression of dihydrodiol dehydrogenase in the resected stage I non-small cell lung cancer

Chih Yi Chen, Chung Ping Hsu, Nan Yung Hsu, Chih Shiun Shih, Tze Yi Lin, Kuan Chih Chow

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Recently, by using differential display on specimens of non-small cell lung cancer (NSCLC), we detected overexpression of dihydrodiol dehydrogenase (DDH) that was rarely expressed in the corresponding normal lung tissue. DDH overexpression was correlated with poor prognosis of patients with advanced NSCLC. Because DDH could metabolize polycyclic aromatic hydrocarbons (PAH) in the liver, DDH overexpression in NSCLC would suggest an association with carcinogenesis and disease progression. In this study, we investigated DDH expression in 103 patients with resected stage I NSCLC. Expression of DDH was detected by using immunohistochemistry. Relation between DDH expression and clinicopathological parameter (age, gender, smoking habit, tumor status, histological type, cell differentiation, local recurrence, distant metastasis or survival) was analyzed by statistical analysis. DDH overexpression was detected in 39 (37.9%) of 103 pathological sections. Frequency of DDH overexpression was significantly higher in male patients (p=0.043) and patients with squamous cell carcinoma (p<0.005). Among 103 patients, 14 patients had local recurrence and 28 patients had distant metastasis during follow-up examination. The 5-year survival rate of these patients was poorer than those who did not have local recurrence or distant metastasis (both were p<0.005, respectively). Although patients with low DDH expression had more favorable outcome than those with DDH overexpression, in terms of survival rate no statistical significance was detected (p=0.889). The results suggest that DDH expression may serve as an early but not prognostic biomarker for patients with resectable stage I NSCLC.

Original languageEnglish
Pages (from-to)515-519
Number of pages5
JournalOncology Reports
Volume9
Issue number3
Publication statusPublished - May 2002
Externally publishedYes

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Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Recurrence
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Survival Rate
Polycyclic Aromatic Hydrocarbons
Habits
Disease Progression
Cell Differentiation
Squamous Cell Carcinoma
Carcinogenesis
Biomarkers
Smoking
Immunohistochemistry
Lung
Survival

Keywords

  • Dihydrodiol dehydrogenase
  • Non-small cell lung cancer
  • Stage I

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Chen, C. Y., Hsu, C. P., Hsu, N. Y., Shih, C. S., Lin, T. Y., & Chow, K. C. (2002). Expression of dihydrodiol dehydrogenase in the resected stage I non-small cell lung cancer. Oncology Reports, 9(3), 515-519.

Expression of dihydrodiol dehydrogenase in the resected stage I non-small cell lung cancer. / Chen, Chih Yi; Hsu, Chung Ping; Hsu, Nan Yung; Shih, Chih Shiun; Lin, Tze Yi; Chow, Kuan Chih.

In: Oncology Reports, Vol. 9, No. 3, 05.2002, p. 515-519.

Research output: Contribution to journalArticle

Chen, CY, Hsu, CP, Hsu, NY, Shih, CS, Lin, TY & Chow, KC 2002, 'Expression of dihydrodiol dehydrogenase in the resected stage I non-small cell lung cancer', Oncology Reports, vol. 9, no. 3, pp. 515-519.
Chen CY, Hsu CP, Hsu NY, Shih CS, Lin TY, Chow KC. Expression of dihydrodiol dehydrogenase in the resected stage I non-small cell lung cancer. Oncology Reports. 2002 May;9(3):515-519.
Chen, Chih Yi ; Hsu, Chung Ping ; Hsu, Nan Yung ; Shih, Chih Shiun ; Lin, Tze Yi ; Chow, Kuan Chih. / Expression of dihydrodiol dehydrogenase in the resected stage I non-small cell lung cancer. In: Oncology Reports. 2002 ; Vol. 9, No. 3. pp. 515-519.
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