Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasia

L. M. Lee, C. C. Pan, C. J. Cheng, C. W. Chi, T. Y. Liu

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Elevated expression of cyclo-oxygenase (COX)-2 has been found in several human cancers, including prostate adenocarcinoma. To evaluate the potential prognostic role of COX-2 in prostate cancer, we assessed the expression of COX-2 in benign prostatic hyperplasia (BPH) and prostate cancer samples employing immunohistochemistry. COX-2 was over-expressed in 15 out of 18 (83%) prostate cancer samples whereas it was detected in only 22% (4 of 18) paired benign tissues. The intensity of immunostaining correlated with the tumor grading. In addition, COX-2 was expressed in 7 of the 22 (32%) BPH samples examined. The significance a COX-2 expression in the BPH samples is not known at present. This data suggest that COX-2 is over-expressed in prostate cancer and COX-2 inhibitors may be useful in combination chemotherapy or chemoprevention for prostate cancer.

Original languageEnglish
Pages (from-to)1291-1294
Number of pages4
JournalAnticancer Research
Volume21
Issue number2 B
Publication statusPublished - 2001
Externally publishedYes

Keywords

  • Benign prostatic hyperplasia
  • Cyclooxygenase-2
  • Expression
  • Prostate cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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