人類舌鱗狀細胞癌中銅鋅超氧化物歧化酶之表現

Translated title of the contribution: Expression of Copper-Zinc Superoxide Dismutase in Squamous Cell Carcinoma of the Human Tongue

賴 銘堂(Ming-Tang Lai), 周 幸華(Hsin-Hua Chou), 西崎 和則(Kazunori Nishizaki), 小川 晃弘(Teruhiro Ogawa), 福島 邦博(Kunihiro Fukushima), 李 文森(Wen-Sen Lee), 李 宏生(Hong-Sheng Lee), 增 田游(Yu Masuda)

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Superoxide radicals(O2), by virtue of their ability to trasform proca-cinogen to carcinogn and can caus chemical modification of DNA, are delieved to be mutagenic and carcinogenic. Superoxide dismutases (SODs) witch can catalyze the dismutation of O2 are therefore considered to be important factors in the pathogenesis and treatment of cancer. Several types of cancer cell have been demonstrated to possess different levels of SODs. The localization and levels of SODs in most carcinomas of the human head and neck not benn extensively investigated.
METHODS: Using immunohistochemical methods this study was designed to detect the expression of copper-zinc SOD (CuZnSOD) in 16 specimens of well-differentiated squa-mous cell carcinoma of human tongue that received neither radiotherapy nor chemother-apy. The relative CuZnSOD levels in different cell types making up the carcionma tissues were also evaluated.
BESULTS: The results showed that the squamous carcinoma cells, squampus epithelial cells, striated muscule cells and vasular endothelial cells strong positive CuZnSOD immunostaining.
CONCLUSIONS: These results may reflect the higher metabolism of squamous carcinoma cells, and may idicate a higher ability of aquamous carcinoma cells to scavenge O2 , thereby enhancing their resistance to the adverse effects of O2 ,
Thereby enhancing their resistance to the advrese effects of O2.
Translated title of the contributionExpression of Copper-Zinc Superoxide Dismutase in Squamous Cell Carcinoma of the Human Tongue
Original languageTraditional Chinese
Pages (from-to)370-375
Number of pages6
JournalJournal of Taiwan Otolaryngology - Head and Neck Surgery
Volume35
Issue number6
Publication statusPublished - 2000

Keywords

  • Squamous cell carcinoma
  • superoxide dismutase
  • superoxide radical

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