Expression of CD86 and increased inflitration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma

Sung Hsin Kuo, Li Tzong Chen, Chi Long Chen, Shin Lian Doong, Kun Huei Yeh, Ming Shiang Wu, Tsui Lien Mao, Hui Chen Hsu, Hsiu Po Wang, Jaw Town Lin, Ann Lii Cheng

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Abstract

Aim: A high percentage of early-stage high-grade gastric mucosa-associated lymphoid tissue (MALT) lymphomas remain Helicobacter pylori (H pylori)-dependent. However, unlike their low-grade counterparts, high-grade gastric MALT lymphomas may progress rapidly if unresponsive to H pylori eradication. It is mandatory to identify markers that may predict the H pylori-dependent status of these tumors. Proliferation of MALT lymphoma cells depends on cognate help and cell-to-cell contact of H pylori-specific intratumoral T-cells. To examine whether the expression of co-stimulatory marker CD86 (B7.2) and the infiltration of CD56 (+) natural killer (NK) cells can be useful markers to predict H pylori-dependent status of high-grade gastric MALT lymphoma. Methods: Lymphoma biopsies from 26 patients who had participated in a prospective study of H pylori-eradication for stage IE high-grade gastric MALT lymphomas were evaluated. Tumors that resolved to Wotherspoon grade II or less after H pylori eradication were classified as H pylori-dependent; others were classified as H pylori-independent. The infiltration of NK cells and the expression of CD86 in pre-treatment paraffin-embedded lymphoma tissues were determined by immunohistochemistry. Results: There were 16 H pylori-dependent and 10 H pylori-independent cases. CD86 expression was detected in 11 (68.8%) of 16 H pylori-dependent cases but in none of 10 H pylori-independent cases (P = 0.001). H pylori-dependent high-grade gastric MALT lymphomas contained significantly higher numbers of CD56 (+) NK cells than H pylori-independent cases (2.8±1.4% vs 1.1±0.8%; P = 0.003). CD86 positive MALT lymphomas also showed significantly increased infiltration of CD56 (+) NK cells compared to CD86-negative cases (2.9±1.1% vs 1.4±1.3%; P = 0.005). Conclusion: These results suggest that the expression of co-stimulatory marker CD86 and the increased infiltration of NK cells are associated with H pylori-dependent state of early-stage high-grade gastric MALT lymphomas.

Original languageEnglish
Pages (from-to)4357-4362
Number of pages6
JournalWorld Journal of Gastroenterology
Volume11
Issue number28
Publication statusPublished - Jul 28 2005

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Marginal Zone B-Cell Lymphoma
Gastric Mucosa
Helicobacter pylori
Natural Killer Cells
Lymphoma

Keywords

  • CD56
  • CD86
  • H pylori
  • MALT lymphoma

ASJC Scopus subject areas

  • Gastroenterology

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Expression of CD86 and increased inflitration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma. / Kuo, Sung Hsin; Chen, Li Tzong; Chen, Chi Long; Doong, Shin Lian; Yeh, Kun Huei; Wu, Ming Shiang; Mao, Tsui Lien; Hsu, Hui Chen; Wang, Hsiu Po; Lin, Jaw Town; Cheng, Ann Lii.

In: World Journal of Gastroenterology, Vol. 11, No. 28, 28.07.2005, p. 4357-4362.

Research output: Contribution to journalArticle

Kuo, SH, Chen, LT, Chen, CL, Doong, SL, Yeh, KH, Wu, MS, Mao, TL, Hsu, HC, Wang, HP, Lin, JT & Cheng, AL 2005, 'Expression of CD86 and increased inflitration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma', World Journal of Gastroenterology, vol. 11, no. 28, pp. 4357-4362.
Kuo, Sung Hsin ; Chen, Li Tzong ; Chen, Chi Long ; Doong, Shin Lian ; Yeh, Kun Huei ; Wu, Ming Shiang ; Mao, Tsui Lien ; Hsu, Hui Chen ; Wang, Hsiu Po ; Lin, Jaw Town ; Cheng, Ann Lii. / Expression of CD86 and increased inflitration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma. In: World Journal of Gastroenterology. 2005 ; Vol. 11, No. 28. pp. 4357-4362.
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abstract = "Aim: A high percentage of early-stage high-grade gastric mucosa-associated lymphoid tissue (MALT) lymphomas remain Helicobacter pylori (H pylori)-dependent. However, unlike their low-grade counterparts, high-grade gastric MALT lymphomas may progress rapidly if unresponsive to H pylori eradication. It is mandatory to identify markers that may predict the H pylori-dependent status of these tumors. Proliferation of MALT lymphoma cells depends on cognate help and cell-to-cell contact of H pylori-specific intratumoral T-cells. To examine whether the expression of co-stimulatory marker CD86 (B7.2) and the infiltration of CD56 (+) natural killer (NK) cells can be useful markers to predict H pylori-dependent status of high-grade gastric MALT lymphoma. Methods: Lymphoma biopsies from 26 patients who had participated in a prospective study of H pylori-eradication for stage IE high-grade gastric MALT lymphomas were evaluated. Tumors that resolved to Wotherspoon grade II or less after H pylori eradication were classified as H pylori-dependent; others were classified as H pylori-independent. The infiltration of NK cells and the expression of CD86 in pre-treatment paraffin-embedded lymphoma tissues were determined by immunohistochemistry. Results: There were 16 H pylori-dependent and 10 H pylori-independent cases. CD86 expression was detected in 11 (68.8{\%}) of 16 H pylori-dependent cases but in none of 10 H pylori-independent cases (P = 0.001). H pylori-dependent high-grade gastric MALT lymphomas contained significantly higher numbers of CD56 (+) NK cells than H pylori-independent cases (2.8±1.4{\%} vs 1.1±0.8{\%}; P = 0.003). CD86 positive MALT lymphomas also showed significantly increased infiltration of CD56 (+) NK cells compared to CD86-negative cases (2.9±1.1{\%} vs 1.4±1.3{\%}; P = 0.005). Conclusion: These results suggest that the expression of co-stimulatory marker CD86 and the increased infiltration of NK cells are associated with H pylori-dependent state of early-stage high-grade gastric MALT lymphomas.",
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AU - Kuo, Sung Hsin

AU - Chen, Li Tzong

AU - Chen, Chi Long

AU - Doong, Shin Lian

AU - Yeh, Kun Huei

AU - Wu, Ming Shiang

AU - Mao, Tsui Lien

AU - Hsu, Hui Chen

AU - Wang, Hsiu Po

AU - Lin, Jaw Town

AU - Cheng, Ann Lii

PY - 2005/7/28

Y1 - 2005/7/28

N2 - Aim: A high percentage of early-stage high-grade gastric mucosa-associated lymphoid tissue (MALT) lymphomas remain Helicobacter pylori (H pylori)-dependent. However, unlike their low-grade counterparts, high-grade gastric MALT lymphomas may progress rapidly if unresponsive to H pylori eradication. It is mandatory to identify markers that may predict the H pylori-dependent status of these tumors. Proliferation of MALT lymphoma cells depends on cognate help and cell-to-cell contact of H pylori-specific intratumoral T-cells. To examine whether the expression of co-stimulatory marker CD86 (B7.2) and the infiltration of CD56 (+) natural killer (NK) cells can be useful markers to predict H pylori-dependent status of high-grade gastric MALT lymphoma. Methods: Lymphoma biopsies from 26 patients who had participated in a prospective study of H pylori-eradication for stage IE high-grade gastric MALT lymphomas were evaluated. Tumors that resolved to Wotherspoon grade II or less after H pylori eradication were classified as H pylori-dependent; others were classified as H pylori-independent. The infiltration of NK cells and the expression of CD86 in pre-treatment paraffin-embedded lymphoma tissues were determined by immunohistochemistry. Results: There were 16 H pylori-dependent and 10 H pylori-independent cases. CD86 expression was detected in 11 (68.8%) of 16 H pylori-dependent cases but in none of 10 H pylori-independent cases (P = 0.001). H pylori-dependent high-grade gastric MALT lymphomas contained significantly higher numbers of CD56 (+) NK cells than H pylori-independent cases (2.8±1.4% vs 1.1±0.8%; P = 0.003). CD86 positive MALT lymphomas also showed significantly increased infiltration of CD56 (+) NK cells compared to CD86-negative cases (2.9±1.1% vs 1.4±1.3%; P = 0.005). Conclusion: These results suggest that the expression of co-stimulatory marker CD86 and the increased infiltration of NK cells are associated with H pylori-dependent state of early-stage high-grade gastric MALT lymphomas.

AB - Aim: A high percentage of early-stage high-grade gastric mucosa-associated lymphoid tissue (MALT) lymphomas remain Helicobacter pylori (H pylori)-dependent. However, unlike their low-grade counterparts, high-grade gastric MALT lymphomas may progress rapidly if unresponsive to H pylori eradication. It is mandatory to identify markers that may predict the H pylori-dependent status of these tumors. Proliferation of MALT lymphoma cells depends on cognate help and cell-to-cell contact of H pylori-specific intratumoral T-cells. To examine whether the expression of co-stimulatory marker CD86 (B7.2) and the infiltration of CD56 (+) natural killer (NK) cells can be useful markers to predict H pylori-dependent status of high-grade gastric MALT lymphoma. Methods: Lymphoma biopsies from 26 patients who had participated in a prospective study of H pylori-eradication for stage IE high-grade gastric MALT lymphomas were evaluated. Tumors that resolved to Wotherspoon grade II or less after H pylori eradication were classified as H pylori-dependent; others were classified as H pylori-independent. The infiltration of NK cells and the expression of CD86 in pre-treatment paraffin-embedded lymphoma tissues were determined by immunohistochemistry. Results: There were 16 H pylori-dependent and 10 H pylori-independent cases. CD86 expression was detected in 11 (68.8%) of 16 H pylori-dependent cases but in none of 10 H pylori-independent cases (P = 0.001). H pylori-dependent high-grade gastric MALT lymphomas contained significantly higher numbers of CD56 (+) NK cells than H pylori-independent cases (2.8±1.4% vs 1.1±0.8%; P = 0.003). CD86 positive MALT lymphomas also showed significantly increased infiltration of CD56 (+) NK cells compared to CD86-negative cases (2.9±1.1% vs 1.4±1.3%; P = 0.005). Conclusion: These results suggest that the expression of co-stimulatory marker CD86 and the increased infiltration of NK cells are associated with H pylori-dependent state of early-stage high-grade gastric MALT lymphomas.

KW - CD56

KW - CD86

KW - H pylori

KW - MALT lymphoma

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