Expression of bcl-2 correlates with poor prognosis and modulates migration of nasopharyngeal carcinoma cells

Mu Kuan Chen, Shun Fa Yang, Jui Chung Lai, Kun Tu Yeh, Jia Sin Yang, Li Sheng Chen, Hui Chuan Chen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: The role of bcl-2 expression, bcl-2 inhibitor HA14-1, and matrix metalloproteinase (MMP)-2 is still unclear in nasopharyngeal carcinoma (NPC). Methods: From 1996 to 2000, 145 patients with newly diagnosed NPC who were treated with high dose radiotherapy were enrolled. The relationship between bcl-2 expression, TNM stage, and disease-specific survival was analyzed. Furthermore, the NPC cell line HONE-1 was used to confirm the relationship between bcl-2 and cell metastasis. Results: Among the 145 patients, 47 (32.4%) of them were bcl-2 positive. The expression of bcl-2 was significantly correlated with neck lymph node metastasis (p = 0.006), and patients with negative bcl-2 expression had better disease-free survival (p = 0.007). A Cox regression model revealed that only bcl-2 expression (p = 0.023) and stage IV (p = 0.043) were statistically significant in the prognosis of NPC. In vitro analysis also showed that treatment with the bcl-2 inhibitor HA14-1 exerted an inhibitory effect on migration and expression of MMP-2 in HONE-1 cells. Conclusions: Bcl-2 expression represents an important and easily assayed prognostic factor, and it may play an important role in lymph node metastasis. Inhibition of the migration mediated by MMP-2 may be a key feature for the prevention of cancer metastasis.

Original languageEnglish
Pages (from-to)400-405
Number of pages6
JournalClinica Chimica Acta
Volume411
Issue number5-6
DOIs
Publication statusPublished - Mar 2 2010
Externally publishedYes

Keywords

  • Bcl-2
  • Inhibitor
  • Matrix metalloproteinases
  • Nasopharyngeal carcinoma
  • Prognosis

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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