Expression of a soluble decoy receptor 3 in patients with diffuse large B-cell lymphoma predicts clinical outcome

Peter Mu Hsin Chang, Po Min Chen, Shie Liang Hsieh, Cheng Hwai Tzeng, Jin Hwang Liu, Tzeon Jye Chiou, Wei Shu Wang, Chueh Chuan Yen, Jyh Pyng Gau, Muh Hwa Yang

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The soluble decoy receptor 3 (DcR3) is a member of the TNF receptor superfamily. It is regarded as a decoy receptor released from tumor cells to escape host immune response by neutralizing the cytotoxic and immunomodulatory effects of FasL, LIGHT and TL1A. Overexpression of DcR3 has been observed in several human malignancies; however, only limited information exists on the role of DcR3 in non-Hodgkin lymphoma especially for B-cell origin. In the current study, the expression profile of DcR3 was analyzed by RT-PCR and immunohistochemistry (IHC) in a set of lymphoma cell lines including T-cell and B-cell lymphomas. The result demonstrated that overexpression of DcR3 was detected in most T-cell lymphoma cells, which was consistent with previous reports. Interestingly, overexpression of DcR3 was also detected both in the B-cell lymphoma cell lines and diffuse large B cell lymphoma (DLBCL) patients. DcR3 overexpression was associated with a worse prognosis in DLBCL patients (p=0.05). An in vitro study showed that neutralization of DcR3 increased the percentage of doxorubicin-mediated apoptosis in two B-cell lymphoma cell lines, which indicated the possibility of DcR3 mediated chemo-resistance in B-cell lymphomas. We suggest that overexpression of DcR3 is associated with a worse prognosis in DLBCL and the possible mechanism may act through the increase of chemo-resistance of lymphoma cells.

Original languageEnglish
Pages (from-to)549-554
Number of pages6
JournalInternational Journal of Oncology
Volume33
Issue number3
DOIs
Publication statusPublished - Sep 2008
Externally publishedYes

Keywords

  • Diffuse large B-cell lymphoma
  • Prognosis
  • Soluble decoy receptor 3

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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