Abstract
Exposure to the mixed indoor air pollutants released from synthetic materials and chemical products poses a serious public health problem, but little evidence has been provided to clarify whether such pollutants at environmentally relevant concentrations produce inheritable germline mutations. In the present study, mice were exposed to samples of indoor air from a newly decorated apartment bedroom. Results showed expanded simple tandem repeat (ESTR) mutations occurring in the germline of control and exposed parents, which were also detected in their offspring using three probes, Ms6-hm, Hm-2, and MMS10. Data indicated that mice being exposed to indoor air triggered a significant increase in frequency of ESTR mutations, which may be due primarily to a rise in mutations inherited through the paternal germline. These results suggest that exposure to a mixture of pollutants in indoor air obtained from an apartment in China induced ESTR mutations. Thus, humans exposed to polluted indoor apartment air in China may be at risk for developing germline mutations.
| Original language | English |
|---|---|
| Pages (from-to) | 1561-1566 |
| Number of pages | 6 |
| Journal | Journal of Toxicology and Environmental Health - Part A: Current Issues |
| Volume | 72 |
| Issue number | 24 |
| DOIs | |
| Publication status | Published - Jan 1 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis
Cite this
Exposure to residential indoor air induces heritable DNA mutations in mice. / Zhou, Yin; Liu, Yunru; Qiu, Wen; Zeng, Jinyan; Chen, Xiaodong; Zhou, Hanzhi; Li, Aiping; Zhou, Jianwei.
In: Journal of Toxicology and Environmental Health - Part A: Current Issues, Vol. 72, No. 24, 01.01.2009, p. 1561-1566.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Exposure to residential indoor air induces heritable DNA mutations in mice
AU - Zhou, Yin
AU - Liu, Yunru
AU - Qiu, Wen
AU - Zeng, Jinyan
AU - Chen, Xiaodong
AU - Zhou, Hanzhi
AU - Li, Aiping
AU - Zhou, Jianwei
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Exposure to the mixed indoor air pollutants released from synthetic materials and chemical products poses a serious public health problem, but little evidence has been provided to clarify whether such pollutants at environmentally relevant concentrations produce inheritable germline mutations. In the present study, mice were exposed to samples of indoor air from a newly decorated apartment bedroom. Results showed expanded simple tandem repeat (ESTR) mutations occurring in the germline of control and exposed parents, which were also detected in their offspring using three probes, Ms6-hm, Hm-2, and MMS10. Data indicated that mice being exposed to indoor air triggered a significant increase in frequency of ESTR mutations, which may be due primarily to a rise in mutations inherited through the paternal germline. These results suggest that exposure to a mixture of pollutants in indoor air obtained from an apartment in China induced ESTR mutations. Thus, humans exposed to polluted indoor apartment air in China may be at risk for developing germline mutations.
AB - Exposure to the mixed indoor air pollutants released from synthetic materials and chemical products poses a serious public health problem, but little evidence has been provided to clarify whether such pollutants at environmentally relevant concentrations produce inheritable germline mutations. In the present study, mice were exposed to samples of indoor air from a newly decorated apartment bedroom. Results showed expanded simple tandem repeat (ESTR) mutations occurring in the germline of control and exposed parents, which were also detected in their offspring using three probes, Ms6-hm, Hm-2, and MMS10. Data indicated that mice being exposed to indoor air triggered a significant increase in frequency of ESTR mutations, which may be due primarily to a rise in mutations inherited through the paternal germline. These results suggest that exposure to a mixture of pollutants in indoor air obtained from an apartment in China induced ESTR mutations. Thus, humans exposed to polluted indoor apartment air in China may be at risk for developing germline mutations.
UR - http://www.scopus.com/inward/record.url?scp=75149194887&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75149194887&partnerID=8YFLogxK
U2 - 10.1080/15287390903232442
DO - 10.1080/15287390903232442
M3 - Article
C2 - 20077230
AN - SCOPUS:75149194887
VL - 72
SP - 1561
EP - 1566
JO - Journal of Toxicology and Environmental Health - Part A: Current Issues
JF - Journal of Toxicology and Environmental Health - Part A: Current Issues
SN - 1528-7394
IS - 24
ER -