Exposure to residential indoor air induces heritable DNA mutations in mice

Yin Zhou, Yunru Liu, Wen Qiu, Jinyan Zeng, Xiaodong Chen, Hanzhi Zhou, Aiping Li, Jianwei Zhou

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Exposure to the mixed indoor air pollutants released from synthetic materials and chemical products poses a serious public health problem, but little evidence has been provided to clarify whether such pollutants at environmentally relevant concentrations produce inheritable germline mutations. In the present study, mice were exposed to samples of indoor air from a newly decorated apartment bedroom. Results showed expanded simple tandem repeat (ESTR) mutations occurring in the germline of control and exposed parents, which were also detected in their offspring using three probes, Ms6-hm, Hm-2, and MMS10. Data indicated that mice being exposed to indoor air triggered a significant increase in frequency of ESTR mutations, which may be due primarily to a rise in mutations inherited through the paternal germline. These results suggest that exposure to a mixture of pollutants in indoor air obtained from an apartment in China induced ESTR mutations. Thus, humans exposed to polluted indoor apartment air in China may be at risk for developing germline mutations.

Original languageEnglish
Pages (from-to)1561-1566
Number of pages6
JournalJournal of Toxicology and Environmental Health - Part A: Current Issues
Volume72
Issue number24
DOIs
Publication statusPublished - Jan 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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