Exposure to environmental tobacco smoke and urinary 1-hydroxypyrene levels in preschool children

Hsiu Ting Tsai, Ming Tsang Wu, Russ Hauser, Ema Rodrigues, Chi Kung Ho, Chia Ling Liu, David C. Christiani

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20 Citations (Scopus)

Abstract

Environmental tobacco smoke (ETS) contains relatively high concentrations of polycyclic aromatic hydrocarbons (PAHs). Urinary 1-hydroxypyrene (1-OHP), a metabolite of pyrene, is a good indicator of PAH exposure in occupational studies. In this study, we investigated the relationship between urinary 1-OHP concentration and ETS exposure in preschool children. Forty preschool children, aged 24-76 months, were studied during November and December, 1999. Two spot-urine specimens (one in the morning immediately after the subject woke up and the other at night before the subject went to bed) were collected 1 day after completion of a questionnaire, in order to determine 1-OHP concentrations by fluorescent spectrophotometry. Overall, urinary 1-OHP concentrations were relatively low but detectable (morning: median, 0.021 μg/g creatinine; range, 0.002-1.019 μg/g creatinine; night: median, 0.015 μg/g creatinine; range, 0.002-1.328 μg/g creatinine). Multiple linear regression analyses revealed that the total number of cigarettes smoked by the children's fathers during the 3 days prior to collection of the urine specimens was significantly associated with their urinary 1-OHP concentrations, after adjusting for other confounders. Each cigarette smoked by a child's father resulted in an average 9.6% increase in 1-OHP concentration in the morning urine specimen (95% confidence interval = 1.8-18.1%; p = 0.02). We did not find a significant increase in the 1-OHP concentration in night urine specimens (p = 0.19). Although the sample size was small, these findings indicate that urinary 1-OHP may be a suitable biomarker of ETS carcinogen exposure in children.

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalKaohsiung Journal of Medical Sciences
Volume19
Issue number3
Publication statusPublished - Mar 1 2003
Externally publishedYes

Keywords

  • Environmental tobacco smoke
  • Preschool children
  • Urinary 1-hydroxypyrene

ASJC Scopus subject areas

  • Medicine(all)

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    Tsai, H. T., Wu, M. T., Hauser, R., Rodrigues, E., Ho, C. K., Liu, C. L., & Christiani, D. C. (2003). Exposure to environmental tobacco smoke and urinary 1-hydroxypyrene levels in preschool children. Kaohsiung Journal of Medical Sciences, 19(3), 97-104.