Exposure to environmental tobacco smoke and urinary 1-hydroxypyrene levels in preschool children

Hsiu Ting Tsai, Ming Tsang Wu, Russ Hauser, Ema Rodrigues, Chi Kung Ho, Chia Ling Liu, David C. Christiani

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Environmental tobacco smoke (ETS) contains relatively high concentrations of polycyclic aromatic hydrocarbons (PAHs). Urinary 1-hydroxypyrene (1-OHP), a metabolite of pyrene, is a good indicator of PAH exposure in occupational studies. In this study, we investigated the relationship between urinary 1-OHP concentration and ETS exposure in preschool children. Forty preschool children, aged 24-76 months, were studied during November and December, 1999. Two spot-urine specimens (one in the morning immediately after the subject woke up and the other at night before the subject went to bed) were collected 1 day after completion of a questionnaire, in order to determine 1-OHP concentrations by fluorescent spectrophotometry. Overall, urinary 1-OHP concentrations were relatively low but detectable (morning: median, 0.021 μg/g creatinine; range, 0.002-1.019 μg/g creatinine; night: median, 0.015 μg/g creatinine; range, 0.002-1.328 μg/g creatinine). Multiple linear regression analyses revealed that the total number of cigarettes smoked by the children's fathers during the 3 days prior to collection of the urine specimens was significantly associated with their urinary 1-OHP concentrations, after adjusting for other confounders. Each cigarette smoked by a child's father resulted in an average 9.6% increase in 1-OHP concentration in the morning urine specimen (95% confidence interval = 1.8-18.1%; p = 0.02). We did not find a significant increase in the 1-OHP concentration in night urine specimens (p = 0.19). Although the sample size was small, these findings indicate that urinary 1-OHP may be a suitable biomarker of ETS carcinogen exposure in children.

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalKaohsiung Journal of Medical Sciences
Volume19
Issue number3
Publication statusPublished - Mar 1 2003
Externally publishedYes

Fingerprint

Environmental Exposure
Preschool Children
Smoke
Tobacco
Creatinine
Polycyclic Aromatic Hydrocarbons
Urine
Tobacco Products
Fathers
Urine Specimen Collection
Spectrophotometry
Occupational Exposure
Carcinogens
Sample Size
Linear Models
Biomarkers
Regression Analysis
Confidence Intervals
1-hydroxypyrene

Keywords

  • Environmental tobacco smoke
  • Preschool children
  • Urinary 1-hydroxypyrene

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tsai, H. T., Wu, M. T., Hauser, R., Rodrigues, E., Ho, C. K., Liu, C. L., & Christiani, D. C. (2003). Exposure to environmental tobacco smoke and urinary 1-hydroxypyrene levels in preschool children. Kaohsiung Journal of Medical Sciences, 19(3), 97-104.

Exposure to environmental tobacco smoke and urinary 1-hydroxypyrene levels in preschool children. / Tsai, Hsiu Ting; Wu, Ming Tsang; Hauser, Russ; Rodrigues, Ema; Ho, Chi Kung; Liu, Chia Ling; Christiani, David C.

In: Kaohsiung Journal of Medical Sciences, Vol. 19, No. 3, 01.03.2003, p. 97-104.

Research output: Contribution to journalArticle

Tsai, HT, Wu, MT, Hauser, R, Rodrigues, E, Ho, CK, Liu, CL & Christiani, DC 2003, 'Exposure to environmental tobacco smoke and urinary 1-hydroxypyrene levels in preschool children', Kaohsiung Journal of Medical Sciences, vol. 19, no. 3, pp. 97-104.
Tsai, Hsiu Ting ; Wu, Ming Tsang ; Hauser, Russ ; Rodrigues, Ema ; Ho, Chi Kung ; Liu, Chia Ling ; Christiani, David C. / Exposure to environmental tobacco smoke and urinary 1-hydroxypyrene levels in preschool children. In: Kaohsiung Journal of Medical Sciences. 2003 ; Vol. 19, No. 3. pp. 97-104.
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